Objetivo "The target of the present project is to fabricate large loading capacity, stimuli-responsive drug delivery nanodevices (DDNDs) with potential application in anticancer therapy. The proposed theme is central to People Programme for Career Development framed under FP7 within a research area which is truly at the cutting-edge and which is strongly interdisciplinary (materials, chemistry and nanoengineering). The proposed work falls directly under “The European Strategy for Nanotechnology and the Nanotechnology plan”. In particular, there are two themes under this Action Plan addressed by this proposal, e.g. Health and NMP (Nanosciences, nanotechnologies, materials and new production technologies). The proposal involves both materials preparation and drug loading/releasing processes. The DDNDs will be made in three steps. Firstly, magnetic Fe3O4 nanoparticles (NPs) are prepared. Then a decomposable FeOOH shell will be coated on the NPs. Finally, the above core-shell structures will again be coated by a layer of mesoporous silica forming core-double shell structure. The DDNDs with increased hollow volume will be obtained by the decomposition of the FeOOH inner shell. Thereafter, the drug loading and releasing will be done in two separated steps where the release can be triggered by a stimulus input, e.g. sharp pH change. All structures/devices obtained from these steps will be thoroughly characterised. The evaluation on the delivery efficiency and improvement on the fabrication process parameters will be made according to the characterisation results. In particular, the ‘zero-release’ before the stimuli input, the load maximization per DDND and the sustainability of the release once triggered will be the main aims to be achieved in the project. As fulfilled, all pre-set training objectives will be realised by the knowledge and competencies gained in the project and will definitely benefit to the candidate career development and mobility among the European Research Area." Ámbito científico engineering and technologynanotechnologynano-materials Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2010-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Aportación de la UE € 209 092,80 Dirección TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Reino Unido Ver en el mapa Región East of England East Anglia Cambridgeshire CC Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Renata Schaeffer (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos