Objective
The objective of this research plan is to develop mathematical foundations and geometric computational algorithms to bio-mimetically model fully customized and complex three-dimensional (3D) heterogeneous (multi-material) structures with controlled material composition and distribution. The proposed work will be used to model active multi-functional porous structures with controlled micro-architecture to satisfy different and sometimes conflicting functional requirements.
First, computational algorithms are proposed to optimally design multi-material with bio-active molecules spatially in porous structures. A new design methodology is proposed to relate material and bioactive distribution to 3D shape (geometry). The internal micro-architecture of porous structures is also optimized based on biological and mechanical requirements. Second, a novel bio-fabrication processed is proposed to fabricate designed multi-functional active porous structures with various biodegradable materials embedded with active bio-molecules directly from the computer models. The proposed methodologies will be applied to 3D tissue scaffolds. Cell migration into design 3D scaffold will be tested in-vitro to assess and optimize the proposed methodologies. The proposed methods will make more advanced active scaffold systems possible. These active multi-functional porous structures could be used to arrange cells in an appropriate 3D configuration and present molecular signals in a spatial and temporal fashion so that the individual cells will grow and form the desired tissue structures.
The results from this research would enable use of active implants, tissue/organ substitutes and micro-scale bio-sensors in many new applications in medicine and biomedical engineering. This project will also advance the knowledge in heterogeneous object modelling in computer-aided design, layered-based fabrication methodologies and biomaterials.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- natural sciences biological sciences biochemistry biomolecules
- natural sciences mathematics pure mathematics geometry
- engineering and technology industrial biotechnology biomaterials
- medical and health sciences medical biotechnology implants
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
34956 Istanbul
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.