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Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment

Objective

Based on epidemiological evidence supporting an ssociation between residential exposure to extremely
low frequency magnetic fields (ELF MF) and childhood leukaemia, ELF MF have been classified as possibly carcinogenic to humans. The proposed project aims to scrutinize the underlying biophysical mechanisms and
to clarify a possible causal relationship between ELF MF exposure and cancer, especially childhood leukaemia. This will be achieved by 1) developing and applying novel experimental and computational techniques to close knowledge gaps in the exposure assessment to ELF MF and 2) applying advanced biological in vitro, ex vivo and in vivo models and techniques under well-defined exposure conditions to test likely interaction mechanisms. The selected experimental approach is based on epidemiological evidence and current knowledge about the molecular processes underlying acute leukaemia in children. It aims to investigate the possible impact of ELF-MF exposure: 1) on the epigenetic dynamics associated with hematopoietic cell lineage commitment and
differentiation; epigenetic signatures will be monitored genome-wide, and mechanisms underlying eventual “misprogramming” will be addressed in gene promoter models; 2) on the alteration of signalling processes in cells; 3) on the induction of possible cytotoxic effects on CD8 positive T cells; and 4) on the genesis or evolution of childhood leukaemia by generating genetically modified advanced animal models. Advanced biophysical simulations with efficient numerical solvers combined with the latest tissue and cellular models will be implemented to support the bioexperiments. A risk assessment will be performed at the end based on studies conducted within the project and correlated to recent studies conducted outside the consortium by adapting and
applying procedures as outlined by the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans.

Call for proposal

FP7-ENV-2011
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT
Address
Zeughausstrasse 43
8004 Zurich
Switzerland
Activity type
Research Organisations
EU contribution
€ 231 958
Administrative Contact
Iris Szankowski (Dr.)

Participants (8)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 725 244,80
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Primo Schär (Prof.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 277 049,60
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 433 245
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Andrea Zeumann (Ms.)
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 156 153,60
Address
Bunteweg 2
30559 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Joppe (Mr.)
Schmid & Partner Engineering AG
Switzerland
EU contribution
€ 490 489,20
Address
Zeughausstrasse 43
8004 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Katja Pokovic (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 666 529,50
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jiménez Arroyo (Mr.)
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
France
EU contribution
€ 173 766
Address
150 Cours Albert Thomas
69372 Lyon Cedex 08
Activity type
Other
Administrative Contact
Olaf Kelm (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 95 535
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Paolo Ravazzani (Dr.)