Skip to main content

Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment

Ziel

Based on epidemiological evidence supporting an ssociation between residential exposure to extremely
low frequency magnetic fields (ELF MF) and childhood leukaemia, ELF MF have been classified as possibly carcinogenic to humans. The proposed project aims to scrutinize the underlying biophysical mechanisms and
to clarify a possible causal relationship between ELF MF exposure and cancer, especially childhood leukaemia. This will be achieved by 1) developing and applying novel experimental and computational techniques to close knowledge gaps in the exposure assessment to ELF MF and 2) applying advanced biological in vitro, ex vivo and in vivo models and techniques under well-defined exposure conditions to test likely interaction mechanisms. The selected experimental approach is based on epidemiological evidence and current knowledge about the molecular processes underlying acute leukaemia in children. It aims to investigate the possible impact of ELF-MF exposure: 1) on the epigenetic dynamics associated with hematopoietic cell lineage commitment and
differentiation; epigenetic signatures will be monitored genome-wide, and mechanisms underlying eventual “misprogramming” will be addressed in gene promoter models; 2) on the alteration of signalling processes in cells; 3) on the induction of possible cytotoxic effects on CD8 positive T cells; and 4) on the genesis or evolution of childhood leukaemia by generating genetically modified advanced animal models. Advanced biophysical simulations with efficient numerical solvers combined with the latest tissue and cellular models will be implemented to support the bioexperiments. A risk assessment will be performed at the end based on studies conducted within the project and correlated to recent studies conducted outside the consortium by adapting and
applying procedures as outlined by the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans.

Aufforderung zur Vorschlagseinreichung

FP7-ENV-2011
Andere Projekte für diesen Aufruf anzeigen

Koordinator

FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT
Adresse
Zeughausstrasse 43
8004 Zurich
Schweiz

Auf der Karte ansehen

Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Iris Szankowski (Dr.)
EU-Beitrag
€ 231 958

Beteiligte (8)

UNIVERSITAT BASEL
Schweiz
EU-Beitrag
€ 725 244,80
Adresse
Petersplatz 1
4051 Basel

Auf der Karte ansehen

Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Primo Schär (Prof.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU-Beitrag
€ 277 049,60
Adresse
Herzl Street 234
7610001 Rehovot

Auf der Karte ansehen

Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Talia Tzahor (Ms.)
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Deutschland
EU-Beitrag
€ 433 245
Adresse
Hansastrasse 27c
80686 Munchen

Auf der Karte ansehen

Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Andrea Zeumann (Ms.)
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Deutschland
EU-Beitrag
€ 156 153,60
Adresse
Bunteweg 2
30559 Hannover

Auf der Karte ansehen

Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Peter Joppe (Mr.)
Schmid & Partner Engineering AG
Schweiz
EU-Beitrag
€ 490 489,20
Adresse
Zeughausstrasse 43
8004 Zurich

Auf der Karte ansehen

Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Katja Pokovic (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spanien
EU-Beitrag
€ 666 529,50
Adresse
Calle Serrano 117
28006 Madrid

Auf der Karte ansehen

Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Eusebio Jiménez Arroyo (Mr.)
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Frankreich
EU-Beitrag
€ 173 766
Adresse
150 Cours Albert Thomas
69372 Lyon Cedex 08

Auf der Karte ansehen

Aktivitätstyp
Other
Kontakt Verwaltung
Olaf Kelm (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italien
EU-Beitrag
€ 95 535
Adresse
Piazzale Aldo Moro 7
00185 Roma

Auf der Karte ansehen

Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Paolo Ravazzani (Dr.)