Project description
Mental health treatment through neuromodulation
Depression, dementia, addiction or obsessive-compulsive disorder affect more than 1 billion people worldwide. With funding from the European Research Council, the BNCI2 project aims to develop an easy system to identify and modify brain activity signals related to such disorders. The idea is that by finely modulating these signals, we can effectively treat the clinical symptoms that they cause, without side effects.Researchers will exploit quantum sensor technology that can target multiple brain areas at millimetre precision. They will combine it with millisecond-precise magnetic stimulation to create a new tool, which will eventually be validated on individuals diagnosed with brain disorders. The project offers promising prospects for clinical diagnosis and treatment of mental health conditions.
Objective
More than 1 billion people worldwide suffer from compromised mental health due to a brain disorder, such as depression, addiction, obsessive-compulsive disorder (OCD) or dementia. While already accounting for 19% of all years lived with disability, the relative share of these disorders is further increasing. Currently, due to the complexity of the human mind and brain, effective and side effect-free treatment options are lacking. To establish such options would not only require identifying the underlying neural substrates of clinical symptoms, but also effective means to directly modulate them.
While advanced neuroimaging could link specific clinical symptoms to the metabolic activity of cortical and subcortical networks or neural circuits, it is unclear how this metabolic activity translates to the continuously evolving dynamics of widespread brain oscillatory activity. A possible way to identify and target such oscillatory brain states would be the use of millimeter-precise and brain state-dependent neuromodulation, e.g. using electric or magnetic fields. However, this could not be established yet because reliable and accurate assessment of brain oscillations is impeded by stimulation artifacts. Moreover, there are no stimulation tools available that provide sufficient focality and steerability to target dynamic brain states at multiple locations with millisecond-precision. Building on our previous work, we will overcome these limitations and establish a new approach that combines quantum sensors offering unprecedented accuracy with closed-loop temporal interference magnetic stimulation to target cortical and subcortical areas at millimeter- and millisecond precision. The system will be validated in persons diagnosed with depression, OCD, addiction, and dementia. Finally, the paradigm will be implemented in a portable system to foster fast adoption in clinical environments.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10117 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.