Objective
A sustainable climate and an ecosystem-friendly economy demands novel ‘cell factories’, in which organisms convert renewable biomass into various biomaterials that would otherwise be derived from fossil fuels or (harsh) chemistry. Especially promising is the use of thermophilic bacteria and archaea that operate at high temperatures, as this can enable more efficient production processes. However, we currently know very little about the cellular protein machinery (or proteome) of thermophiles, which limits our ability to efficiently use them in cell factories.
The PROHITS project therefore creates a network for nine doctoral candidates to develop mass spectrometry (MS) driven proteomics approaches to study the in vivo proteome of thermophiles, and to apply the obtained insights to cell factory development. The first aim is to perform proteomics on single prokaryotic cells using advanced microfluidics, MS instrumentation and data analysis, to observe how proteomes vary in individual cells. The second aim is to enable thermal proteome profiling approaches for thermophiles, to observe how their proteomes respond to temperature changes. The third aim is to apply the proteomics insights for predicting how in vivo proteins respond to high temperatures, and to create more detailed genome-scale models of thermophiles. This information is used to improve an existing cell factory that produces lipids for medicine encapsulation, and to expand knowledge of thermophiles that can be used as cell factories.
To achieve this, PROHITS creates an integrated pipeline of experimental and computational approaches, built within a collaborative network of academics and industry. The doctoral candidates will obtain comprehensive and highly complementary skills, ranging from cutting-edge proteomics analysis, over data analysis and prediction, to systems biology approaches to optimize cell factories, which will enable them as future leaders of a thriving and forward-looking European bioeconomy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules lipids
- social sciences economics and business economics bioeconomy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1050 BRUSSEL
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.