Objective
The heat shock response is important in eukaryotes as a protective mechanism for the stress of change in temperature or other environmental factors, and it has been the subject for targets for therapeutic intervention. Recently, it has been found that a conserved non-coding RNA is involved in mediating the heat shock response. The RNA forms a stable complex with elongation factor eEF1A to activate the heat shock transcription factor. The project will involve the preparation of recombinant RNA-protein complex for structural elucidation by X-ray crystallography and biochemical and biophysical characterisation. The structural information may help to explain how the RNA triggers the response, most likely through a conformational switch. Currently there is no structural information available for the heat shock RNA or for any of the several other large non-coding RNAs that have recently been identified in eukaryotes. The structural information may help to explain how the heat shock RNA and other non-coding RNAs function, and may also be useful in the long term for therapeutic intervention in response to chemotherapy of cancerous cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.