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Contenuto archiviato il 2024-06-18

Structural and functional studies of structured RNA involved in heat shock response

Obiettivo

The heat shock response is important in eukaryotes as a protective mechanism for the stress of change in temperature or other environmental factors, and it has been the subject for targets for therapeutic intervention. Recently, it has been found that a conserved non-coding RNA is involved in mediating the heat shock response. The RNA forms a stable complex with elongation factor eEF1A to activate the heat shock transcription factor. The project will involve the preparation of recombinant RNA-protein complex for structural elucidation by X-ray crystallography and biochemical and biophysical characterisation. The structural information may help to explain how the RNA triggers the response, most likely through a conformational switch. Currently there is no structural information available for the heat shock RNA or for any of the several other large non-coding RNAs that have recently been identified in eukaryotes. The structural information may help to explain how the heat shock RNA and other non-coding RNAs function, and may also be useful in the long term for therapeutic intervention in response to chemotherapy of cancerous cells.

Campo scientifico

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.

Invito a presentare proposte

FP7-PEOPLE-IEF-2008
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Coordinatore

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Contributo UE
€ 137 147,09
Indirizzo
TRINITY LANE THE OLD SCHOOLS
CB2 1TN Cambridge
Regno Unito

Mostra sulla mappa

Regione
East of England East Anglia Cambridgeshire CC
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Charles Shannon (Mr.)
Collegamenti
Costo totale
Nessun dato