Objective
Within the broad spectrum of biological soft matter systems, large proteins and protein assemblies occupy a central role. These molecules are extremely versatile: they can catalyze chemical reactions, transport atoms and molecules across the cellular membrane, bind to foreign bodies to be destroyed, or combine into large molecular machines that perform a variety of different tasks. One of the most prominent problems in the computational study of these macromolecules is that the cost of using accurate atomistic models dramatically increases with system size. Simplified, coarse-grained representations offer an elegant and effective alternative to high-resolution models, and enable the simulation of large systems over extended time scales; the other side of the coin, however, is that the missing chemical detail often represents an insurmountable limitation to the realistic reproduction of the properties of interest. The main goal of the VARIAMOLS project is to develop and apply novel computer-aided methods for the study of large molecular assemblies and their dynamics, thus bridging the existing gap between computational cost and chemical accuracy. Specifically, the research will unfold along two intertwined lines: 1) the development of non-uniform resolution models of the system, which optimize the balance between detail and efficiency; and 2) the study of dynamics-mediated properties of protein assemblies. The working philosophy of VARIAMOLS has two complementary and strictly interconnected aspects: on the one hand, the theoretical and algorithmic advancement of the methods currently employed to represent and simulate biomolecules; on the other hand, the systematic application of the developed methods to real-life case studies of great relevance for medical science and technology, with a particular focus on viruses and antibodies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences physical sciences condensed matter physics soft matter physics
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences
- natural sciences mathematics applied mathematics mathematical model
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
38122 Trento
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.