Final Report Summary - HIGEN (ADVANCED STATISTICAL METHODS FOR HIGH-DIMENSIONAL GENETIC STUDIES) The HIGEN project had two main aims. Firstly, to develop and apply novel, fast statistical methods that allow estimation of the maternal and paternal DNA sequences from large scale human genetic datasets. Our work in this area lead to the development of key reference datasets, such as the Haplotype Reference Consortium data and the UK Biobank imputed dataset. Second, we aimed to develop methods for searching for disease genes using datasets where more than one disease outcome of trait had been measured. The idea was to pool strength across traits to help increase the chance of discovering new disease genes. Our work led to the discovery of new disease genes for brain imaging traits and this work was published in Nature.
