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Affording Recovery In Stroke

Objective

Stroke poses a massive clinical, social and economic burden, yet we have very limited effective therapies. This inadequacy is in spite of intensive research efforts and numerous failed clinical trials. Leading European stroke researchers and clinicians with a track record of established cooperation will share their complementary expertise, and team up with SME partners with high profile R&D and ongoing, promising clinical trials. Based on a thorough reexamination of the failures and bottlenecks of previous attempts to develop effective therapies for stroke, the ARISE consortium proposes an integrative and innovative approach to overcome the translational roadblock. ARISE research will result in a number of novel, promising therapies, including safer thrombolytics, modulators of the immune system and inflammation, compounds inducing or mimicking endogenous neuroprotection, therapies to induce repair of lost function, as well as a fast way to selectively cool the brain. We will work on a common model and methods platform, in which for the first time relevant comorbidities, gender, age, and long term outcomes will be investigated. Training of young researchers will lead to a standardisation and harmonisation of laboratory practices within the consortium, and implement the standard operating procedures generated by the consortium. Importantly, the ARISE consortium combines expertise in clinical as well as preclinical stroke research. To obtain clinical proof of principle and to translate our findings into effective therapy of stroke, ARISE is conducting clinical trials and has established a dedicated clinical platform to (1) provide advice to the basic researchers of the consortium with regard to clinically relevant questions and modelling, (2) to periodically review the ongoing development of innovative therapies, and to (3) ultimately take the most promising preclinical strategy developed by the ARISE consortium into a multicenter randomized clinical trial.

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/basic medicine/immunology

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 178 932
Administrative Contact
Eveline Fräßdorf (Ms.)

Participants (16)

ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 744 675
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jari Koistinaho (Prof.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 1 229 189
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roland Andersson (Prof.)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 783 133
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Norbert Huber (Dr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 745 590
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Juan Dr Rodés (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 856 568
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 068 362
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Rofigua Hakem (Ms.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 587 296
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Martin Schwab (Prof.)
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 549 568
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa
Activity type
Research Organisations
Administrative Contact
Marcin Szumowski (Dr.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 517 696
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Saskia Vanden Broeck (Ms.)
QUICK COOL AB
Sweden
EU contribution
€ 318 296
Address
Scheelevagen Beta 6 Ideon Science Park 17
22370 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Fredrik Lindblad (Mr.)
PAION DEUTSCHLAND GMBH
Germany
EU contribution
€ 122 721
Address
Martinstrasse 10-12
52062 Aachen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karl-Uwe Petersen (Prof.)
SYGNIS BIOSCIENCE GMBH & CO. KG

Participation ended

Germany
EU contribution
€ 275 653
Address
Im Neuenheimer Feld 515
69120 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frank Zimmermann (Mr.)
NSGENE AS
Denmark
EU contribution
€ 92 423
Address
Baltorpvej 154
2750 Ballerup
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jette Lindskov (Ms.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Germany
EU contribution
€ 505 500
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 351 944
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz (Mr.)
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 319 230
Address
Ratzeburger Allee 160
23562 Lubeck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabriele Kipke (Ms.)