Objetivo "Osteoporosis is a disabling disease and the incidence is expected to increase significantly over the next decades due to an increase in the elderly population. This will lead to an enormous economical burden both in the European Union and in the rest of the world. Osteoporosis should be treated early in order to prevent the bone fractures related to the disease, and a number of anti-resorptive treatments exist that can reduce the loss of bone. However, the possibilities of regaining already lost bone are limited, as only one anabolic treatment option (parathyroid hormone (PTH) )is available on the market. In most countries PTH is restricted to the most severe cases of osteoporosis with multiple fractures. Thus new anabolic treatment options for osteoporosis are highly warranted. Purinergic signalling, where nucleotides such as ATP act as extracellular signalling molecules, is a rapidly expanding field. The purinergic system has plays a central role in bone physiology, and bone deposition and resorption are finely tuned by extracellular nucleotides. Furthermore, the ""purinergic system"" is now believed to be one of the main transducing pathways of mechanical stimulation, a stimulus that is highly anabolic to bone. The overall aim of the proposal is to definitively prove the role of ATP and purinergic receptor signalling in the control of bone formation and homeostasis, thereby proving the potential of the system as a target for the development of new anabolic treatment regimens for osteoporosis. The aim will be addressed by examining the role of ATP as a signalling molecule in bone, the pathways and purinergic receptors involved in the signalling and their role in bone formation and homeostasis in vitro. Furthermore, translational studies in in vivo P2 receptor knock out mice will be used to show the role of the signalling pathways on bone, as well as small-scale clinical proof-of-concept studies to prove the potential of the system in targeting osteoporosis." Ámbito científico natural sciencesbiological sciencesgeneticsnucleotidesmedical and health sciencesbasic medicinephysiologyhomeostasis Palabras clave Osteoporosis atp bone formation bone homeostasis osteoblast osteoclast purinergic signalling Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH-2007-2.4.5-3 - Osteoporosis: signalling pathways in bone formation and homeostasis Convocatoria de propuestas FP7-HEALTH-2007-A Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador REGION HOVEDSTADEN Aportación de la UE € 483 800,00 Dirección KONGENS VAENGE 2 3400 Hillerod Dinamarca Ver en el mapa Región Danmark Hovedstaden Nordsjælland Tipo de actividad Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contacto administrativo Jesper Thyge Johansen (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY COLLEGE LONDON Aportación de la UE € 416 912,00 Dirección GOWER STREET WC1E 6BT LONDON Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Michael Browne (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITEIT MAASTRICHT Países Bajos Aportación de la UE € 450 440,00 Dirección MINDERBROEDERSBERG 4 6200 MD Maastricht Ver en el mapa Región Zuid-Nederland Limburg (NL) Zuid-Limburg Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Joseph I H Janssen (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITA DEGLI STUDI DI FERRARA Italia Aportación de la UE € 292 800,00 Dirección VIA ARIOSTO 35 44121 Ferrara Ver en el mapa Región Nord-Est Emilia-Romagna Ferrara Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Francesco Di Virgilio (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF LIVERPOOL Reino Unido Aportación de la UE € 317 936,00 Dirección BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool Ver en el mapa Región North West (England) Merseyside Liverpool Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Colin Cooper (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF SHEFFIELD Reino Unido Aportación de la UE € 673 594,00 Dirección FIRTH COURT WESTERN BANK S10 2TN Sheffield Ver en el mapa Región Yorkshire and the Humber South Yorkshire Sheffield Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Gill Wells (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITE LIBRE DE BRUXELLES Bélgica Aportación de la UE € 363 200,00 Dirección AVENUE FRANKLIN ROOSEVELT 50 1050 Bruxelles / Brussel Ver en el mapa Región Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Jean-Marie Boeynaems (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos