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Multifunctional DNA light-switches: sensors and devices

Objectif

Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies.

Champ scientifique (EuroSciVoc)

Mots‑clés

Programme(s)

Thème(s)

Appel à propositions

FP7-PEOPLE-2007-4-2-IIF
Voir d’autres projets de cet appel

Régime de financement

MC-IIF - International Incoming Fellowships (IIF)

Coordinateur

THE UNIVERSITY OF SHEFFIELD
Contribution de l’UE
€ 169 957,94
Adresse
FIRTH COURT WESTERN BANK
S10 2TN SHEFFIELD
Royaume-Uni
Région
Yorkshire and the Humber South Yorkshire Sheffield
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée