Application of Droplet-Based Microfluidics for the Screening of Supramolecular Catalysts

Projektinformationen

MICRODROPCAT

ID Finanzhilfevereinbarung: 219305

Abgeschlossenes Projekt

Startdatum 1 Juli 2008

Enddatum 31 Dezember 2009

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 157 733,20

EU-Beitrag € 157 733,20

Koordiniert durch

UNIVERSITEIT VAN AMSTERDAM
Netherlands

Ziel

In this project we propose to develop new methodologies to prepare and screen large libraries of homogeneous catalysts based on supramolecular (self-assembled) ligands using droplet-based microfluidics. Presently, the discovery and design of efficient homogeneous catalysts still relies on time intensive trial-and-error methodology. To overcome these limitations, a new paradigm shift for the discovery of effective ligands relies on the supramolecular self-assembly of libraries of ligand through reversible non-covalent interactions. This significantly increases the potential chemical space within which an optimal ligand set can be found. The full potential of this methodology is impeded by current synthesis and screening techniques which rely on macroscale (mL) trial for all the ligands sets and reaction conditions. One effective strategy to increase the rate at which reactions can be performed at is through extensive miniaturization of the reaction vessel. Recent advances in droplet-based microfluidics have enabled the effective screening of reaction conditions on a nano- to pico- liter scale. We thus propose to develop, in collaboration with a lab-on-a-chip research group, a modular droplet-based microfluidic device which will enable the generation, within a nanoliter droplet, of supramolecular catalyst made up of self-assembled ligands around a transition metal. These catalytic droplets will then be merged with a stream of reactants to form a nanoliter-size reaction size vessel which will enable the catalytic activity of the self-assembled catalyst to be evaluated. The intended outcome of this project is to greatly accelerate the speed at which an active catalyst can be identified at. This will have a broad impact on the chemical community for which screening methodologies have become an integral part of the discovery process (e.g. drug discovery).

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › physical sciences › classical mechanics › fluid mechanics › microfluidics
• engineering and technology › other engineering and technologies › microtechnology › lab on a chip
• natural sciences › chemical sciences › catalysis

Schlüsselbegriffe

• Chemical engineering
• Combinatorial chemistry
• Homogeneous catalysis
• Microfluidics
• Organometallic chemistry
• supramolecular catalysis

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2007-2-1-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

UNIVERSITEIT VAN AMSTERDAM

Kontakt Verwaltung

Jo Lansbergen (Ms.)

• EU-Beitrag: € 157 733,20
• Adresse: SPUI 21 ; 1012WX Amsterdam ; Niederlande
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten