Objectif In this project we propose to develop new methodologies to prepare and screen large libraries of homogeneous catalysts based on supramolecular (self-assembled) ligands using droplet-based microfluidics. Presently, the discovery and design of efficient homogeneous catalysts still relies on time intensive trial-and-error methodology. To overcome these limitations, a new paradigm shift for the discovery of effective ligands relies on the supramolecular self-assembly of libraries of ligand through reversible non-covalent interactions. This significantly increases the potential chemical space within which an optimal ligand set can be found. The full potential of this methodology is impeded by current synthesis and screening techniques which rely on macroscale (mL) trial for all the ligands sets and reaction conditions. One effective strategy to increase the rate at which reactions can be performed at is through extensive miniaturization of the reaction vessel. Recent advances in droplet-based microfluidics have enabled the effective screening of reaction conditions on a nano- to pico- liter scale. We thus propose to develop, in collaboration with a lab-on-a-chip research group, a modular droplet-based microfluidic device which will enable the generation, within a nanoliter droplet, of supramolecular catalyst made up of self-assembled ligands around a transition metal. These catalytic droplets will then be merged with a stream of reactants to form a nanoliter-size reaction size vessel which will enable the catalytic activity of the self-assembled catalyst to be evaluated. The intended outcome of this project is to greatly accelerate the speed at which an active catalyst can be identified at. This will have a broad impact on the chemical community for which screening methodologies have become an integral part of the discovery process (e.g. drug discovery). Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsengineering and technologyother engineering and technologiesmicrotechnologylab on a chipnatural scienceschemical sciencescatalysis Mots‑clés Chemical engineering Combinatorial chemistry Homogeneous catalysis Microfluidics Organometallic chemistry supramolecular catalysis Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2007-2-1-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur UNIVERSITEIT VAN AMSTERDAM Contribution de l’UE € 157 733,20 Adresse SPUI 21 1012WX Amsterdam Pays-Bas Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Higher or Secondary Education Establishments Contact administratif Jo Lansbergen (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée