Objetivo Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commercialization of engineered products. Similar to other biotechnology sectors (e.g. vaccines or recombinant protein production), bioreactor systems could play a central role in establishing engineered tissues in the clinic. In fact, by automating and streamlining manufacturing processes, they would allow to improve product reproducibility, safety, standardization and possibly reach cost-effectiveness. This project aims at the development, pre-clinical and clinical testing of a sensor-based bioreactor system for the production of functional, autologous engineered grafts with reproducible properties. The bioreactor-based manufacturing paradigm will be addressed in the specific context of cartilage repair. Innovative features of the proposed tissue engineering strategy will include: (i) an automated and controlled production system, (ii) bioreactor conforming to regulatory guidelines, (iii) simplified, streamlined, and scalable tissue engineering process, (iv) on-line monitoring of culture/quality parameters, and (v) data management systems for traceability. To achieve these goals, BIO-COMET brings together internationally renowned leaders in the field of regenerative medicine, from academic, clinical and industrial research institutions. Successful implementation of the project will be instrumental to extend use of bioreactor-based platforms beyond cartilage tissue engineering, with the ultimate goal to facilitate broad utilization and commercialization of cell-based grafts as therapeutic solutions. Ámbito científico engineering and technologymechanical engineeringmanufacturing engineeringengineering and technologyenvironmental biotechnologybioremediationbioreactorsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2011.1.4-2 - Tools, technologies and devices for application in regenerative medicine Convocatoria de propuestas FP7-HEALTH-2011-two-stage Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador UNIVERSITATSSPITAL BASEL Aportación de la UE € 1 269 000,00 Dirección HEBELSTRASSE 32 4031 Basel Suiza Ver en el mapa Región Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo de actividad Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contacto administrativo Ivan Martin (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY OF BRISTOL Reino Unido Aportación de la UE € 559 892,60 Dirección BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Ver en el mapa Región South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Maria Davies (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos SVEUCILISTE U ZAGREBU Croacia Aportación de la UE € 614 729,60 Dirección TRG REPUBLIKE HRVATSKE 14 10000 Zagreb Ver en el mapa Región Hrvatska Grad Zagreb Grad Zagreb Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Hrvoje Matakovic (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ISTITUTO ORTOPEDICO RIZZOLI Italia Aportación de la UE € 620 500,00 Dirección VIA DI BARBIANO 1/10 40136 Bologna Ver en el mapa Región Nord-Est Emilia-Romagna Bologna Tipo de actividad Research Organisations Contacto administrativo Andrea Rizzi (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CELLEC BIOTEK AG Suiza Aportación de la UE € 885 000,00 Dirección VOGESENSTRASSE 135 4056 BASEL Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Montefiori Michele (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos PRESENS PRECISION SENSING GMBH Alemania Aportación de la UE € 568 200,00 Dirección AM BIOPARK 11 93053 Regensburg Ver en el mapa Región Bayern Oberpfalz Regensburg, Kreisfreie Stadt Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Christian Krause (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos HOLOSTEM TERAPIE AVANZATE SRL Italia Aportación de la UE € 429 500,40 Dirección VIA GLAUCO GOTTARDI 100 41125 Modena Ver en el mapa Región Nord-Est Emilia-Romagna Modena Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Graziella Pellegrini (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos OCTANE BIOTECH INC Canadá Aportación de la UE € 641 268,00 Dirección CATARAQUI WOODS DRIVE 640 K7P 2Y5 KINGSTON Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Timothy Smith (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos FIN-CERAMICA FAENZA SPA Italia Aportación de la UE € 406 276,50 Dirección Via Granarolo 177/3 48018 Faenza Ver en el mapa Región Nord-Est Emilia-Romagna Ravenna Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Elisa Figallo (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos