Objetivo "Plant diseases represent a significant threat to global food security. One of the most notorious plant pathogens is the Irish potato famine organism Phytophthora infestans. P. infestans, the causal agent of potato and tomato late blight, continues to cost modern agriculture billions of euros annually. The most sustainable strategy to manage late blight is to breed broad-spectrum disease resistance into potato and tomato. However, current disease resistance breeding approaches are slow, inefficient, and have taken little advantage of emerging knowledge of pathogen mechanisms. Resistance genes have been identified, bred, and deployed in agriculture without detailed knowledge of the effectors they are sensing – a ‘blind’ approach. The overall aim of this proposal is to exploit state of the art findings on pathogen effector biology to drive the development of new approaches to breeding disease resistant crops. Our long-term objective is to generate late blight resistant crop varieties. The central hypothesis of the proposed research is that mutations in plant resistance and effector target genes can result in broad-spectrum resistance to late blight. The rationale behind this research is based on exciting preliminary data that demonstrated (i) there is a core set of effectors in P. infestans; (ii) plant proteins targeted by P. infestans effectors are important components of the immune response; and (iii) single amino acid changes in a potato resistance protein can result in expanded effector recognition. To achieve our goal, we plan to pursue the following specific objectives:1. Understand the molecular details of how three P. infestans effectors modulate plant immunity.2. Generate synthetic plant resistance genes with expanded recognition of P. infestans effectors.3. Generate synthetic plant effector targets with modified interaction with P. infestans effectors.4. Use the synthetic genes to engineer broad-spectrum late blight resistance." Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesnutritionagricultural sciencesagriculture, forestry, and fisheriesagriculturenatural scienceschemical sciencesorganic chemistryamines Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS9 - ERC Advanced Grant - Applied life sciences and biotechnology Convocatoria de propuestas ERC-2011-ADG_20110310 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida THE SAINSBURY LABORATORY Aportación de la UE € 1 959 957,00 Dirección Norwich Research Park, Colney Lane NR47UH Norwich Reino Unido Ver en el mapa Región East of England East Anglia Norwich and East Norfolk Tipo de actividad Research Organisations Contacto administrativo Debbie Feather (Ms.) Investigador principal Sophien Kamoun (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo THE SAINSBURY LABORATORY Reino Unido Aportación de la UE € 1 959 957,00 Dirección Norwich Research Park, Colney Lane NR47UH Norwich Ver en el mapa Región East of England East Anglia Norwich and East Norfolk Tipo de actividad Research Organisations Contacto administrativo Debbie Feather (Ms.) Investigador principal Sophien Kamoun (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos JOHN INNES CENTRE Reino Unido Aportación de la UE € 536 878,00 Dirección NORWICH RESEARCH PARK COLNEY NR4 7UH Norwich Ver en el mapa Región East of England East Anglia Breckland and South Norfolk Tipo de actividad Research Organisations Contacto administrativo Mary Anderson (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
