Chemical Biology in Zebrafish: Drug-Leads and New Targets in the Melanocyte Lineage and Melanoma

Pubblicazioni

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells

Autori: Hannah Brunsdon, Alessandro Brombin, Samuel Peterson, John H. Postlethwait, E. Elizabeth Patton
Pubblicato in: Development, 2022, ISSN 1477-9129
Editore: Company of Biologists
DOI: 10.1242/dev.200277

Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish

Autori: Jana Travnickova, Sarah Muise, Sonia Wojciechowska, Alessandro Brombin, Zhiqiang Zeng, Adelaide I J Young, Cameron Wyatt, E Elizabeth Patton
Pubblicato in: Disease Models and Mechanisms, 2022, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.049566

Spontaneously occurring melanoma in animals and their relevance to human melanoma

Autori: van der Weyden L, Brenn T, Patton EE, Wood GA, Adams DJ
Pubblicato in: The Journal of Pathology, 2020, ISSN 1096-9896
Editore: John Wiley and Sons Inc
DOI: 10.1002/path.5505

Long-term non-invasive drug treatments in adult zebrafish that lead to melanoma drug resistance

Autori: Yuting Lu, E. Elizabeth Patton
Pubblicato in: Disease Models and Mechanisms, 2022, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.049401

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

Autori: He S, Zimmerman MW, Layden HM, Berezovskaya A, Etchin J, Martel MW, Thurston G, Jing CB, van Rooijen E, Kaufman CK, Rodig SJ, Zon LI, Patton EE, Mansour MR, Look AT
Pubblicato in: Oncogene, 2021, ISSN 1476-5594
Editore: Springer Nature Ltd
DOI: 10.1038/s41388-021-01926-y

Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials

Autori: Patton EE, Zon LI, Langenau DM
Pubblicato in: Nature Reviews Drug Discovery, 2021, ISSN 1474-1784
Editore: Springer Nature Ltd
DOI: 10.1038/s41573-021-00210-8

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models

Autori: Jana Travnickova, E Elizabeth Patton
Pubblicato in: The Journal of investigative dermatology, 2021, ISSN 1523-1747
Editore: Elsevier
DOI: 10.1016/j.jid.2020.12.007

NRASQ61K melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells

Autori: Banik I, Cheng PF, Dooley CM, Travnickova J, Merteroglu M, Dummer R, Patton EE, Busch-Nentwich EM, Levesque MP
Pubblicato in: Pigment Cell Melanoma Research, 2020, ISSN 1755-148X
Editore: John Wiley & Sons Ltd
DOI: 10.1111/pcmr.12925

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Autori: Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas S. Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M. Keppler-Noreuil, Amjad Khan, Marjorie J. Lindhurst, Mark Lipson, Sahar Mansour,
Pubblicato in: Journal of Clinical Investigation, Numero 128/4, 2018, Pagina/e 1496-1508, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI98589

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Autori: Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.30657

Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma

Autori: Maria S. Soengas, E. Elizabeth Patton
Pubblicato in: Cell Stem Cell, Numero 21/5, 2017, Pagina/e 559-561, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2017.10.009

Cell signalling: Red alert about lipid's role in skin cancer

Autori: Ian J. Jackson, E. Elizabeth Patton
Pubblicato in: Nature, Numero 549/7672, 2017, Pagina/e 337-339, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature23550

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

Autori: Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Sonia Wojciechowska, Richard J. White, John E. Collins, Derek L. Stemple, Till Bartke, Marie E. Mathers, E. Elizabeth Patton, Elisabeth M. Busch-Nentwich
Pubblicato in: PLOS Genetics, Numero 13/8, 2017, Pagina/e e1006959, ISSN 1553-7404
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1006959

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo

Autori: Gareth Griffiths, Ferenc Müller, Johan Ledin, E. Elizabeth Patton, Tor Gjøen, Viola Hélène Lobert, Hanne Cecilie Winther-Larsen, Mary Mullins, Jean-Stephane Joly, Finn-Arne Weltzien, Charles McLean Press, Peter Aleström
Pubblicato in: Zebrafish, Numero 13/2, 2016, Pagina/e 132-137, ISSN 1545-8547
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/zeb.2015.1212

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Autori: Sana Sarvi, Richard Crispin, Yuting Lu, Lifan Zeng, Thomas D. Hurley, Douglas R. Houston, Alex von Kriegsheim, Che-Hong Chen, Daria Mochly-Rosen, Marco Ranzani, Marie E. Mathers, Xiaowei Xu, Wei Xu, David J. Adams, Neil O. Carragher, Mayumi Fujita, Lynn Schuchter, Asier Unciti-Broceta, Valerie G. Brunton, E. Elizabeth Patton
Pubblicato in: Cell Chemical Biology, 2018, ISSN 2451-9456
Editore: Cell Press
DOI: 10.1016/j.chembiol.2018.09.005

Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

Autori: N. P. Macdonald, F. Zhu, C. J. Hall, J. Reboud, P. S. Crosier, E. E. Patton, D. Wlodkowic, J. M. Cooper
Pubblicato in: Lab Chip, Numero 16/2, 2016, Pagina/e 291-297, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/C5LC01374G

Cross-species models of human melanoma

Autori: Louise van der Weyden, E Elizabeth Patton, Geoffrey A Wood, Alastair K Foote, Thomas Brenn, Mark J Arends, David J Adams
Pubblicato in: The Journal of Pathology, Numero 238/2, 2016, Pagina/e 152-165, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.4632

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Autori: Craig Fraser, John C. Dawson, Reece Dowling, Douglas R. Houston, Jason T. Weiss, Alison F. Munro, Morwenna Muir, Lea Harrington, Scott P. Webster, Margaret C. Frame, Valerie G. Brunton, E. Elizabeth Patton, Neil O. Carragher, Asier Unciti-Broceta
Pubblicato in: Journal of Medicinal Chemistry, Numero 59/10, 2016, Pagina/e 4697-4710, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b00065

Generation and analysis of zebrafish melanoma models

Autori: S. Wojciechowska, E. van Rooijen, C. Ceol, E.E. Patton, R.M. White
Pubblicato in: Methods Cell Biol., 2016, Pagina/e 531-549, ISSN 0091-679X
Editore: Academic Press
DOI: 10.1016/bs.mcb.2016.03.008

Let's make it happen: for gender equality in science!

Autori: Lidia Kos, E. Elizabeth Patton, Maria S. Soengas
Pubblicato in: Pigment Cell & Melanoma Research, Numero 28/6, 2015, Pagina/e 641-642, ISSN 1755-1471
Editore: Basil Blackwell
DOI: 10.1111/pcmr.12421

Melanoma Regression and Recurrence in Zebrafish

Autori: Sonia Wojciechowska, Zhiqiang Zeng, James A. Lister, Craig J. Ceol, E. Elizabeth Patton
Pubblicato in: Methods Mol Biol., 2016, Pagina/e 143-153, ISSN 1940-6029
Editore: Springer New York
DOI: 10.1007/978-1-4939-3771-4_10

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease

Autori: Jana Travnickova, Sonia Wojciechowska, Ava Khamseh, Philippe Gautier, Daniel V. Brown, Thomas Lefevre, Alessandro Brombin, Ailith Ewing, Amy Capper, Michaela Spitzer, Ramile Dilshat, Colin A. Semple, Marie E. Mathers, James A. Lister, Eiríkur Steingrimsson, Thierry Voet, Chris P. Ponting, E. Elizabeth Patton
Pubblicato in: Cancer Research, Numero 79/22, 2019, Pagina/e 5769-5784, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-0037

Fishing for ancestry

Autori: Hannah Brunsdon, E Elizabeth Patton
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.39524

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish

Autori: Karen Camargo-Sosa, Sarah Colanesi, Jeanette Müller, Stefan Schulte-Merker, Derek Stemple, E. Elizabeth Patton, Robert N. Kelsh
Pubblicato in: PLOS Genetics, Numero 15/2, 2019, Pagina/e e1007941, ISSN 1553-7404
Editore: Public Library of Science (PloS)
DOI: 10.1371/journal.pgen.1007941

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Autori: Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhiqiang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, Eiríkur Steingrímsson, Katherine L. B. Borden, E. Elizabeth Patton, Colin R. Goding
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 115/37, 2018, Pagina/e E8668-E8677, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1810498115

Bright insights into palladium-triggered local chemotherapy

Autori: Thomas L. Bray, Mark Salji, Alessandro Brombin, Ana M. Pérez-López, Belén Rubio-Ruiz, Laura C. A. Galbraith, E. Elizabeth Patton, Hing Y. Leung, Asier Unciti-Broceta
Pubblicato in: Chemical Science, Numero 9/37, 2018, Pagina/e 7354-7361, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c8sc02291g

Spotlight on zebrafish: the next wave of translational research

Autori: E. Elizabeth Patton, David M. Tobin
Pubblicato in: Disease Models & Mechanisms, Numero 12/3, 2019, Pagina/e dmm039370, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.039370

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae

Autori: Zhiqiang Zeng, Juan Lopez-Baez, Laura Lleras-Forero, Hannah Brunsdon, Cameron Wyatt, Witold Rybski, Nicholas Hastie, Stefan Schulte-Merker, E Patton
Pubblicato in: BIO-PROTOCOL, Numero 8/23, 2018, ISSN 2331-8325
Editore: Bio-protocol
DOI: 10.21769/bioprotoc.3100

MITF reprograms the extracellular matrix and focal adhesion in melanoma

Autori: Ramile Dilshat, Valerie Fock, Colin Kenny, Ilse Gerritsen, Romain Maurice Jacques Lasseur, Jana Travnickova, Ossia M Eichhoff, Philipp Cerny, Katrin Möller, Sara Sigurbjörnsdóttir, Kritika Kirty, Berglind Ósk Einarsdottir, Phil F Cheng, Mitchell Levesque, Robert A Cornell, E Elizabeth Patton, Lionel Larue, Marie de Tayrac, Erna Magnúsdóttir, Margrét Helga Ögmundsdóttir, Eirikur Steingrims
Pubblicato in: MITF reprograms the extracellular matrix and focal adhesion in melanoma, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.63093

Melanoma models for the next generation of therapies

Autori: E Elizabeth Patton, Kristen L Mueller, David J Adams, Niroshana Anandasabapathy, Andrew E Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J Ceol, Christin E Burd, Ping Chi, Meenhard Herlyn, Sheri L Holmen, Florian A Karreth, Charles K Kaufman, Shaheen Khan, Sebastian Kobold , Eleonora Leucci, Carmit Levy, David B Lombard, Amanda W Lund, Kerrie L Marie, Jean-Christophe Marine, Richard Marais, Mar
Pubblicato in: Cancer Cell, 2021, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2021.01.011

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation

Autori: Jeanette A Johansson, Kerrie L Marie, Yuting Lu, Alessandro Brombin, Cristina Santoriello, Zhiqiang Zeng, Judith Zich, Philippe Gautier, Alex von Kriegsheim, Hannah Brunsdon, Ann P Wheeler, Marcel Dreger, Douglas R Houston, Christopher M Dooley, Andrew H Sims, Elisabeth M Busch-Nentwich, Leonard I Zon, Robert S Illingworth, E Elizabeth Patton
Pubblicato in: Developmental cell, 2020, ISSN 1878-1551
Editore: Cell press
DOI: 10.1016/j.devcel.2020.06.013

FGFR3 is a positive regulator of osteoblast expansion and differentiation during zebrafish skull vault development

Autori: Emilie Dambroise; Ivan Ktorza; Alessandro Brombin; Ghaith Abdessalem; Joanne Edouard; Joanne Edouard; Marine Luka; Imke A. K. Fiedler; Olivia Binder; Olivier Pellé; E. Elizabeth Patton; Björn Busse; Mickaël M. Ménager; Frédéric Sohm; Laurence Legeai-Mallet
Pubblicato in: Journal of Bone and Mineral Research, Numero 5, 2020, ISSN 1523-4681
Editore: John Wiley & Sons Inc
DOI: 10.1101/2020.01.02.884155

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

Autori: Alessandro Brombin, Daniel J. Simpson, Jana Travnickova, Hannah Brunsdon, Zhiqiang Zeng, Yuting Lu, Adelaide I.J. Young, Tamir Chandra, E. Elizabeth Patton
Pubblicato in: Cell reports, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.110234

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Autori: Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR
Pubblicato in: Molecular Cell, 2020, ISSN 1097-4164
Editore: Cell Press
DOI: 10.1016/j.molcel.2020.05.025

Welcoming new Editors to Disease Models & Mechanisms

Autori: Patton EE, Hooper K
Pubblicato in: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.049120

Working to enhance the accessibility of Disease Models & Mechanisms

Autori: Hackett R, Patton EE
Pubblicato in: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.049470

The twin pillars of Disease Models & Mechanisms

Autori: Patton EE
Pubblicato in: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.048951

Models and Mechanisms for COVID-19 Research

Autori: Kirsty M Hooper, E Elizabeth Patton
Pubblicato in: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.049163

Supporting women in science at PCMR

Autori: Ashani T. Weeraratna, E. Elizabeth Patton
Pubblicato in: Pigment Cell & Melanoma Research, Numero 32/4, 2019, Pagina/e 484-485, ISSN 1755-1471
Editore: Basil Blackwell
DOI: 10.1111/pcmr.12798

Developmental disorders Journal Meeting: a collaboration between Development and Disease Models & Mechanisms.

Autori: Hooper KM, Justice MJ, Patton EE.
Pubblicato in: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Editore: Company of Biologists
DOI: 10.1242/dmm.049268

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