Chemical Biology in Zebrafish: Drug-Leads and New Targets in the Melanocyte Lineage and Melanoma

Publikacje

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells

Autorzy: Hannah Brunsdon, Alessandro Brombin, Samuel Peterson, John H. Postlethwait, E. Elizabeth Patton
Opublikowane w: Development, 2022, ISSN 1477-9129
Wydawca: Company of Biologists
DOI: 10.1242/dev.200277

Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish

Autorzy: Jana Travnickova, Sarah Muise, Sonia Wojciechowska, Alessandro Brombin, Zhiqiang Zeng, Adelaide I J Young, Cameron Wyatt, E Elizabeth Patton
Opublikowane w: Disease Models and Mechanisms, 2022, ISSN 1754-8411
Wydawca: Company of Biologists
DOI: 10.1242/dmm.049566

Spontaneously occurring melanoma in animals and their relevance to human melanoma

Autorzy: van der Weyden L, Brenn T, Patton EE, Wood GA, Adams DJ
Opublikowane w: The Journal of Pathology, 2020, ISSN 1096-9896
Wydawca: John Wiley and Sons Inc
DOI: 10.1002/path.5505

Long-term non-invasive drug treatments in adult zebrafish that lead to melanoma drug resistance

Autorzy: Yuting Lu, E. Elizabeth Patton
Opublikowane w: Disease Models and Mechanisms, 2022, ISSN 1754-8411
Wydawca: Company of Biologists
DOI: 10.1242/dmm.049401

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

Autorzy: He S, Zimmerman MW, Layden HM, Berezovskaya A, Etchin J, Martel MW, Thurston G, Jing CB, van Rooijen E, Kaufman CK, Rodig SJ, Zon LI, Patton EE, Mansour MR, Look AT
Opublikowane w: Oncogene, 2021, ISSN 1476-5594
Wydawca: Springer Nature Ltd
DOI: 10.1038/s41388-021-01926-y

Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials

Autorzy: Patton EE, Zon LI, Langenau DM
Opublikowane w: Nature Reviews Drug Discovery, 2021, ISSN 1474-1784
Wydawca: Springer Nature Ltd
DOI: 10.1038/s41573-021-00210-8

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models

Autorzy: Jana Travnickova, E Elizabeth Patton
Opublikowane w: The Journal of investigative dermatology, 2021, ISSN 1523-1747
Wydawca: Elsevier
DOI: 10.1016/j.jid.2020.12.007

NRASQ61K melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells

Autorzy: Banik I, Cheng PF, Dooley CM, Travnickova J, Merteroglu M, Dummer R, Patton EE, Busch-Nentwich EM, Levesque MP
Opublikowane w: Pigment Cell Melanoma Research, 2020, ISSN 1755-148X
Wydawca: John Wiley & Sons Ltd
DOI: 10.1111/pcmr.12925

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Autorzy: Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas S. Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M. Keppler-Noreuil, Amjad Khan, Marjorie J. Lindhurst, Mark Lipson, Sahar Mansour,
Opublikowane w: Journal of Clinical Investigation, Numer 128/4, 2018, Strona(/y) 1496-1508, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/JCI98589

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Autorzy: Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton
Opublikowane w: eLife, Numer 7, 2018, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/eLife.30657

Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma

Autorzy: Maria S. Soengas, E. Elizabeth Patton
Opublikowane w: Cell Stem Cell, Numer 21/5, 2017, Strona(/y) 559-561, ISSN 1934-5909
Wydawca: Cell Press
DOI: 10.1016/j.stem.2017.10.009

Cell signalling: Red alert about lipid's role in skin cancer

Autorzy: Ian J. Jackson, E. Elizabeth Patton
Opublikowane w: Nature, Numer 549/7672, 2017, Strona(/y) 337-339, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature23550

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

Autorzy: Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Sonia Wojciechowska, Richard J. White, John E. Collins, Derek L. Stemple, Till Bartke, Marie E. Mathers, E. Elizabeth Patton, Elisabeth M. Busch-Nentwich
Opublikowane w: PLOS Genetics, Numer 13/8, 2017, Strona(/y) e1006959, ISSN 1553-7404
Wydawca: Public Library of Science
DOI: 10.1371/journal.pgen.1006959

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo

Autorzy: Gareth Griffiths, Ferenc Müller, Johan Ledin, E. Elizabeth Patton, Tor Gjøen, Viola Hélène Lobert, Hanne Cecilie Winther-Larsen, Mary Mullins, Jean-Stephane Joly, Finn-Arne Weltzien, Charles McLean Press, Peter Aleström
Opublikowane w: Zebrafish, Numer 13/2, 2016, Strona(/y) 132-137, ISSN 1545-8547
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/zeb.2015.1212

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Autorzy: Sana Sarvi, Richard Crispin, Yuting Lu, Lifan Zeng, Thomas D. Hurley, Douglas R. Houston, Alex von Kriegsheim, Che-Hong Chen, Daria Mochly-Rosen, Marco Ranzani, Marie E. Mathers, Xiaowei Xu, Wei Xu, David J. Adams, Neil O. Carragher, Mayumi Fujita, Lynn Schuchter, Asier Unciti-Broceta, Valerie G. Brunton, E. Elizabeth Patton
Opublikowane w: Cell Chemical Biology, 2018, ISSN 2451-9456
Wydawca: Cell Press
DOI: 10.1016/j.chembiol.2018.09.005

Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

Autorzy: N. P. Macdonald, F. Zhu, C. J. Hall, J. Reboud, P. S. Crosier, E. E. Patton, D. Wlodkowic, J. M. Cooper
Opublikowane w: Lab Chip, Numer 16/2, 2016, Strona(/y) 291-297, ISSN 1473-0197
Wydawca: Royal Society of Chemistry
DOI: 10.1039/C5LC01374G

Cross-species models of human melanoma

Autorzy: Louise van der Weyden, E Elizabeth Patton, Geoffrey A Wood, Alastair K Foote, Thomas Brenn, Mark J Arends, David J Adams
Opublikowane w: The Journal of Pathology, Numer 238/2, 2016, Strona(/y) 152-165, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.4632

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Autorzy: Craig Fraser, John C. Dawson, Reece Dowling, Douglas R. Houston, Jason T. Weiss, Alison F. Munro, Morwenna Muir, Lea Harrington, Scott P. Webster, Margaret C. Frame, Valerie G. Brunton, E. Elizabeth Patton, Neil O. Carragher, Asier Unciti-Broceta
Opublikowane w: Journal of Medicinal Chemistry, Numer 59/10, 2016, Strona(/y) 4697-4710, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b00065

Generation and analysis of zebrafish melanoma models

Autorzy: S. Wojciechowska, E. van Rooijen, C. Ceol, E.E. Patton, R.M. White
Opublikowane w: Methods Cell Biol., 2016, Strona(/y) 531-549, ISSN 0091-679X
Wydawca: Academic Press
DOI: 10.1016/bs.mcb.2016.03.008

Let's make it happen: for gender equality in science!

Autorzy: Lidia Kos, E. Elizabeth Patton, Maria S. Soengas
Opublikowane w: Pigment Cell & Melanoma Research, Numer 28/6, 2015, Strona(/y) 641-642, ISSN 1755-1471
Wydawca: Basil Blackwell
DOI: 10.1111/pcmr.12421

Melanoma Regression and Recurrence in Zebrafish

Autorzy: Sonia Wojciechowska, Zhiqiang Zeng, James A. Lister, Craig J. Ceol, E. Elizabeth Patton
Opublikowane w: Methods Mol Biol., 2016, Strona(/y) 143-153, ISSN 1940-6029
Wydawca: Springer New York
DOI: 10.1007/978-1-4939-3771-4_10

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease

Autorzy: Jana Travnickova, Sonia Wojciechowska, Ava Khamseh, Philippe Gautier, Daniel V. Brown, Thomas Lefevre, Alessandro Brombin, Ailith Ewing, Amy Capper, Michaela Spitzer, Ramile Dilshat, Colin A. Semple, Marie E. Mathers, James A. Lister, Eiríkur Steingrimsson, Thierry Voet, Chris P. Ponting, E. Elizabeth Patton
Opublikowane w: Cancer Research, Numer 79/22, 2019, Strona(/y) 5769-5784, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-0037

Fishing for ancestry

Autorzy: Hannah Brunsdon, E Elizabeth Patton
Opublikowane w: eLife, Numer 7, 2018, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.39524

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish

Autorzy: Karen Camargo-Sosa, Sarah Colanesi, Jeanette Müller, Stefan Schulte-Merker, Derek Stemple, E. Elizabeth Patton, Robert N. Kelsh
Opublikowane w: PLOS Genetics, Numer 15/2, 2019, Strona(/y) e1007941, ISSN 1553-7404
Wydawca: Public Library of Science (PloS)
DOI: 10.1371/journal.pgen.1007941

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Autorzy: Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhiqiang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, Eiríkur Steingrímsson, Katherine L. B. Borden, E. Elizabeth Patton, Colin R. Goding
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 115/37, 2018, Strona(/y) E8668-E8677, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1810498115

Bright insights into palladium-triggered local chemotherapy

Autorzy: Thomas L. Bray, Mark Salji, Alessandro Brombin, Ana M. Pérez-López, Belén Rubio-Ruiz, Laura C. A. Galbraith, E. Elizabeth Patton, Hing Y. Leung, Asier Unciti-Broceta
Opublikowane w: Chemical Science, Numer 9/37, 2018, Strona(/y) 7354-7361, ISSN 2041-6520
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c8sc02291g

Spotlight on zebrafish: the next wave of translational research

Autorzy: E. Elizabeth Patton, David M. Tobin
Opublikowane w: Disease Models & Mechanisms, Numer 12/3, 2019, Strona(/y) dmm039370, ISSN 1754-8403
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dmm.039370

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae

Autorzy: Zhiqiang Zeng, Juan Lopez-Baez, Laura Lleras-Forero, Hannah Brunsdon, Cameron Wyatt, Witold Rybski, Nicholas Hastie, Stefan Schulte-Merker, E Patton
Opublikowane w: BIO-PROTOCOL, Numer 8/23, 2018, ISSN 2331-8325
Wydawca: Bio-protocol
DOI: 10.21769/bioprotoc.3100

MITF reprograms the extracellular matrix and focal adhesion in melanoma

Autorzy: Ramile Dilshat, Valerie Fock, Colin Kenny, Ilse Gerritsen, Romain Maurice Jacques Lasseur, Jana Travnickova, Ossia M Eichhoff, Philipp Cerny, Katrin Möller, Sara Sigurbjörnsdóttir, Kritika Kirty, Berglind Ósk Einarsdottir, Phil F Cheng, Mitchell Levesque, Robert A Cornell, E Elizabeth Patton, Lionel Larue, Marie de Tayrac, Erna Magnúsdóttir, Margrét Helga Ögmundsdóttir, Eirikur Steingrims
Opublikowane w: MITF reprograms the extracellular matrix and focal adhesion in melanoma, 2021, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.63093

Melanoma models for the next generation of therapies

Autorzy: E Elizabeth Patton, Kristen L Mueller, David J Adams, Niroshana Anandasabapathy, Andrew E Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J Ceol, Christin E Burd, Ping Chi, Meenhard Herlyn, Sheri L Holmen, Florian A Karreth, Charles K Kaufman, Shaheen Khan, Sebastian Kobold , Eleonora Leucci, Carmit Levy, David B Lombard, Amanda W Lund, Kerrie L Marie, Jean-Christophe Marine, Richard Marais, Mar
Opublikowane w: Cancer Cell, 2021, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2021.01.011

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation

Autorzy: Jeanette A Johansson, Kerrie L Marie, Yuting Lu, Alessandro Brombin, Cristina Santoriello, Zhiqiang Zeng, Judith Zich, Philippe Gautier, Alex von Kriegsheim, Hannah Brunsdon, Ann P Wheeler, Marcel Dreger, Douglas R Houston, Christopher M Dooley, Andrew H Sims, Elisabeth M Busch-Nentwich, Leonard I Zon, Robert S Illingworth, E Elizabeth Patton
Opublikowane w: Developmental cell, 2020, ISSN 1878-1551
Wydawca: Cell press
DOI: 10.1016/j.devcel.2020.06.013

FGFR3 is a positive regulator of osteoblast expansion and differentiation during zebrafish skull vault development

Autorzy: Emilie Dambroise; Ivan Ktorza; Alessandro Brombin; Ghaith Abdessalem; Joanne Edouard; Joanne Edouard; Marine Luka; Imke A. K. Fiedler; Olivia Binder; Olivier Pellé; E. Elizabeth Patton; Björn Busse; Mickaël M. Ménager; Frédéric Sohm; Laurence Legeai-Mallet
Opublikowane w: Journal of Bone and Mineral Research, Numer 5, 2020, ISSN 1523-4681
Wydawca: John Wiley & Sons Inc
DOI: 10.1101/2020.01.02.884155

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

Autorzy: Alessandro Brombin, Daniel J. Simpson, Jana Travnickova, Hannah Brunsdon, Zhiqiang Zeng, Yuting Lu, Adelaide I.J. Young, Tamir Chandra, E. Elizabeth Patton
Opublikowane w: Cell reports, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.110234

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Autorzy: Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR
Opublikowane w: Molecular Cell, 2020, ISSN 1097-4164
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2020.05.025

Welcoming new Editors to Disease Models & Mechanisms

Autorzy: Patton EE, Hooper K
Opublikowane w: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Wydawca: Company of Biologists
DOI: 10.1242/dmm.049120

Working to enhance the accessibility of Disease Models & Mechanisms

Autorzy: Hackett R, Patton EE
Opublikowane w: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Wydawca: Company of Biologists
DOI: 10.1242/dmm.049470

The twin pillars of Disease Models & Mechanisms

Autorzy: Patton EE
Opublikowane w: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Wydawca: Company of Biologists
DOI: 10.1242/dmm.048951

Models and Mechanisms for COVID-19 Research

Autorzy: Kirsty M Hooper, E Elizabeth Patton
Opublikowane w: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Wydawca: Company of Biologists
DOI: 10.1242/dmm.049163

Supporting women in science at PCMR

Autorzy: Ashani T. Weeraratna, E. Elizabeth Patton
Opublikowane w: Pigment Cell & Melanoma Research, Numer 32/4, 2019, Strona(/y) 484-485, ISSN 1755-1471
Wydawca: Basil Blackwell
DOI: 10.1111/pcmr.12798

Developmental disorders Journal Meeting: a collaboration between Development and Disease Models & Mechanisms.

Autorzy: Hooper KM, Justice MJ, Patton EE.
Opublikowane w: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Wydawca: Company of Biologists
DOI: 10.1242/dmm.049268

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