Chemical Biology in Zebrafish: Drug-Leads and New Targets in the Melanocyte Lineage and Melanoma

Publicaciones

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells

Autores: Hannah Brunsdon, Alessandro Brombin, Samuel Peterson, John H. Postlethwait, E. Elizabeth Patton
Publicado en: Development, 2022, ISSN 1477-9129
Editor: Company of Biologists
DOI: 10.1242/dev.200277

Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish

Autores: Jana Travnickova, Sarah Muise, Sonia Wojciechowska, Alessandro Brombin, Zhiqiang Zeng, Adelaide I J Young, Cameron Wyatt, E Elizabeth Patton
Publicado en: Disease Models and Mechanisms, 2022, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.049566

Spontaneously occurring melanoma in animals and their relevance to human melanoma

Autores: van der Weyden L, Brenn T, Patton EE, Wood GA, Adams DJ
Publicado en: The Journal of Pathology, 2020, ISSN 1096-9896
Editor: John Wiley and Sons Inc
DOI: 10.1002/path.5505

Long-term non-invasive drug treatments in adult zebrafish that lead to melanoma drug resistance

Autores: Yuting Lu, E. Elizabeth Patton
Publicado en: Disease Models and Mechanisms, 2022, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.049401

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

Autores: He S, Zimmerman MW, Layden HM, Berezovskaya A, Etchin J, Martel MW, Thurston G, Jing CB, van Rooijen E, Kaufman CK, Rodig SJ, Zon LI, Patton EE, Mansour MR, Look AT
Publicado en: Oncogene, 2021, ISSN 1476-5594
Editor: Springer Nature Ltd
DOI: 10.1038/s41388-021-01926-y

Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials

Autores: Patton EE, Zon LI, Langenau DM
Publicado en: Nature Reviews Drug Discovery, 2021, ISSN 1474-1784
Editor: Springer Nature Ltd
DOI: 10.1038/s41573-021-00210-8

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models

Autores: Jana Travnickova, E Elizabeth Patton
Publicado en: The Journal of investigative dermatology, 2021, ISSN 1523-1747
Editor: Elsevier
DOI: 10.1016/j.jid.2020.12.007

NRASQ61K melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells

Autores: Banik I, Cheng PF, Dooley CM, Travnickova J, Merteroglu M, Dummer R, Patton EE, Busch-Nentwich EM, Levesque MP
Publicado en: Pigment Cell Melanoma Research, 2020, ISSN 1755-148X
Editor: John Wiley & Sons Ltd
DOI: 10.1111/pcmr.12925

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Autores: Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas S. Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M. Keppler-Noreuil, Amjad Khan, Marjorie J. Lindhurst, Mark Lipson, Sahar Mansour,
Publicado en: Journal of Clinical Investigation, Edición 128/4, 2018, Página(s) 1496-1508, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI98589

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Autores: Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton
Publicado en: eLife, Edición 7, 2018, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.30657

Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma

Autores: Maria S. Soengas, E. Elizabeth Patton
Publicado en: Cell Stem Cell, Edición 21/5, 2017, Página(s) 559-561, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2017.10.009

Cell signalling: Red alert about lipid's role in skin cancer

Autores: Ian J. Jackson, E. Elizabeth Patton
Publicado en: Nature, Edición 549/7672, 2017, Página(s) 337-339, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature23550

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

Autores: Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Sonia Wojciechowska, Richard J. White, John E. Collins, Derek L. Stemple, Till Bartke, Marie E. Mathers, E. Elizabeth Patton, Elisabeth M. Busch-Nentwich
Publicado en: PLOS Genetics, Edición 13/8, 2017, Página(s) e1006959, ISSN 1553-7404
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1006959

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo

Autores: Gareth Griffiths, Ferenc Müller, Johan Ledin, E. Elizabeth Patton, Tor Gjøen, Viola Hélène Lobert, Hanne Cecilie Winther-Larsen, Mary Mullins, Jean-Stephane Joly, Finn-Arne Weltzien, Charles McLean Press, Peter Aleström
Publicado en: Zebrafish, Edición 13/2, 2016, Página(s) 132-137, ISSN 1545-8547
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/zeb.2015.1212

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Autores: Sana Sarvi, Richard Crispin, Yuting Lu, Lifan Zeng, Thomas D. Hurley, Douglas R. Houston, Alex von Kriegsheim, Che-Hong Chen, Daria Mochly-Rosen, Marco Ranzani, Marie E. Mathers, Xiaowei Xu, Wei Xu, David J. Adams, Neil O. Carragher, Mayumi Fujita, Lynn Schuchter, Asier Unciti-Broceta, Valerie G. Brunton, E. Elizabeth Patton
Publicado en: Cell Chemical Biology, 2018, ISSN 2451-9456
Editor: Cell Press
DOI: 10.1016/j.chembiol.2018.09.005

Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

Autores: N. P. Macdonald, F. Zhu, C. J. Hall, J. Reboud, P. S. Crosier, E. E. Patton, D. Wlodkowic, J. M. Cooper
Publicado en: Lab Chip, Edición 16/2, 2016, Página(s) 291-297, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/C5LC01374G

Cross-species models of human melanoma

Autores: Louise van der Weyden, E Elizabeth Patton, Geoffrey A Wood, Alastair K Foote, Thomas Brenn, Mark J Arends, David J Adams
Publicado en: The Journal of Pathology, Edición 238/2, 2016, Página(s) 152-165, ISSN 0022-3417
Editor: John Wiley & Sons Inc.
DOI: 10.1002/path.4632

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Autores: Craig Fraser, John C. Dawson, Reece Dowling, Douglas R. Houston, Jason T. Weiss, Alison F. Munro, Morwenna Muir, Lea Harrington, Scott P. Webster, Margaret C. Frame, Valerie G. Brunton, E. Elizabeth Patton, Neil O. Carragher, Asier Unciti-Broceta
Publicado en: Journal of Medicinal Chemistry, Edición 59/10, 2016, Página(s) 4697-4710, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b00065

Generation and analysis of zebrafish melanoma models

Autores: S. Wojciechowska, E. van Rooijen, C. Ceol, E.E. Patton, R.M. White
Publicado en: Methods Cell Biol., 2016, Página(s) 531-549, ISSN 0091-679X
Editor: Academic Press
DOI: 10.1016/bs.mcb.2016.03.008

Let's make it happen: for gender equality in science!

Autores: Lidia Kos, E. Elizabeth Patton, Maria S. Soengas
Publicado en: Pigment Cell & Melanoma Research, Edición 28/6, 2015, Página(s) 641-642, ISSN 1755-1471
Editor: Basil Blackwell
DOI: 10.1111/pcmr.12421

Melanoma Regression and Recurrence in Zebrafish

Autores: Sonia Wojciechowska, Zhiqiang Zeng, James A. Lister, Craig J. Ceol, E. Elizabeth Patton
Publicado en: Methods Mol Biol., 2016, Página(s) 143-153, ISSN 1940-6029
Editor: Springer New York
DOI: 10.1007/978-1-4939-3771-4_10

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease

Autores: Jana Travnickova, Sonia Wojciechowska, Ava Khamseh, Philippe Gautier, Daniel V. Brown, Thomas Lefevre, Alessandro Brombin, Ailith Ewing, Amy Capper, Michaela Spitzer, Ramile Dilshat, Colin A. Semple, Marie E. Mathers, James A. Lister, Eiríkur Steingrimsson, Thierry Voet, Chris P. Ponting, E. Elizabeth Patton
Publicado en: Cancer Research, Edición 79/22, 2019, Página(s) 5769-5784, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-0037

Fishing for ancestry

Autores: Hannah Brunsdon, E Elizabeth Patton
Publicado en: eLife, Edición 7, 2018, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.39524

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish

Autores: Karen Camargo-Sosa, Sarah Colanesi, Jeanette Müller, Stefan Schulte-Merker, Derek Stemple, E. Elizabeth Patton, Robert N. Kelsh
Publicado en: PLOS Genetics, Edición 15/2, 2019, Página(s) e1007941, ISSN 1553-7404
Editor: Public Library of Science (PloS)
DOI: 10.1371/journal.pgen.1007941

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Autores: Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhiqiang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, Eiríkur Steingrímsson, Katherine L. B. Borden, E. Elizabeth Patton, Colin R. Goding
Publicado en: Proceedings of the National Academy of Sciences, Edición 115/37, 2018, Página(s) E8668-E8677, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1810498115

Bright insights into palladium-triggered local chemotherapy

Autores: Thomas L. Bray, Mark Salji, Alessandro Brombin, Ana M. Pérez-López, Belén Rubio-Ruiz, Laura C. A. Galbraith, E. Elizabeth Patton, Hing Y. Leung, Asier Unciti-Broceta
Publicado en: Chemical Science, Edición 9/37, 2018, Página(s) 7354-7361, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c8sc02291g

Spotlight on zebrafish: the next wave of translational research

Autores: E. Elizabeth Patton, David M. Tobin
Publicado en: Disease Models & Mechanisms, Edición 12/3, 2019, Página(s) dmm039370, ISSN 1754-8403
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dmm.039370

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae

Autores: Zhiqiang Zeng, Juan Lopez-Baez, Laura Lleras-Forero, Hannah Brunsdon, Cameron Wyatt, Witold Rybski, Nicholas Hastie, Stefan Schulte-Merker, E Patton
Publicado en: BIO-PROTOCOL, Edición 8/23, 2018, ISSN 2331-8325
Editor: Bio-protocol
DOI: 10.21769/bioprotoc.3100

MITF reprograms the extracellular matrix and focal adhesion in melanoma

Autores: Ramile Dilshat, Valerie Fock, Colin Kenny, Ilse Gerritsen, Romain Maurice Jacques Lasseur, Jana Travnickova, Ossia M Eichhoff, Philipp Cerny, Katrin Möller, Sara Sigurbjörnsdóttir, Kritika Kirty, Berglind Ósk Einarsdottir, Phil F Cheng, Mitchell Levesque, Robert A Cornell, E Elizabeth Patton, Lionel Larue, Marie de Tayrac, Erna Magnúsdóttir, Margrét Helga Ögmundsdóttir, Eirikur Steingrims
Publicado en: MITF reprograms the extracellular matrix and focal adhesion in melanoma, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.63093

Melanoma models for the next generation of therapies

Autores: E Elizabeth Patton, Kristen L Mueller, David J Adams, Niroshana Anandasabapathy, Andrew E Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J Ceol, Christin E Burd, Ping Chi, Meenhard Herlyn, Sheri L Holmen, Florian A Karreth, Charles K Kaufman, Shaheen Khan, Sebastian Kobold , Eleonora Leucci, Carmit Levy, David B Lombard, Amanda W Lund, Kerrie L Marie, Jean-Christophe Marine, Richard Marais, Mar
Publicado en: Cancer Cell, 2021, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2021.01.011

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation

Autores: Jeanette A Johansson, Kerrie L Marie, Yuting Lu, Alessandro Brombin, Cristina Santoriello, Zhiqiang Zeng, Judith Zich, Philippe Gautier, Alex von Kriegsheim, Hannah Brunsdon, Ann P Wheeler, Marcel Dreger, Douglas R Houston, Christopher M Dooley, Andrew H Sims, Elisabeth M Busch-Nentwich, Leonard I Zon, Robert S Illingworth, E Elizabeth Patton
Publicado en: Developmental cell, 2020, ISSN 1878-1551
Editor: Cell press
DOI: 10.1016/j.devcel.2020.06.013

FGFR3 is a positive regulator of osteoblast expansion and differentiation during zebrafish skull vault development

Autores: Emilie Dambroise; Ivan Ktorza; Alessandro Brombin; Ghaith Abdessalem; Joanne Edouard; Joanne Edouard; Marine Luka; Imke A. K. Fiedler; Olivia Binder; Olivier Pellé; E. Elizabeth Patton; Björn Busse; Mickaël M. Ménager; Frédéric Sohm; Laurence Legeai-Mallet
Publicado en: Journal of Bone and Mineral Research, Edición 5, 2020, ISSN 1523-4681
Editor: John Wiley & Sons Inc
DOI: 10.1101/2020.01.02.884155

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

Autores: Alessandro Brombin, Daniel J. Simpson, Jana Travnickova, Hannah Brunsdon, Zhiqiang Zeng, Yuting Lu, Adelaide I.J. Young, Tamir Chandra, E. Elizabeth Patton
Publicado en: Cell reports, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.110234

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

Autores: Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR
Publicado en: Molecular Cell, 2020, ISSN 1097-4164
Editor: Cell Press
DOI: 10.1016/j.molcel.2020.05.025

Welcoming new Editors to Disease Models & Mechanisms

Autores: Patton EE, Hooper K
Publicado en: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.049120

Working to enhance the accessibility of Disease Models & Mechanisms

Autores: Hackett R, Patton EE
Publicado en: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.049470

The twin pillars of Disease Models & Mechanisms

Autores: Patton EE
Publicado en: Disease Models & Mechanisms, 2021, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.048951

Models and Mechanisms for COVID-19 Research

Autores: Kirsty M Hooper, E Elizabeth Patton
Publicado en: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.049163

Supporting women in science at PCMR

Autores: Ashani T. Weeraratna, E. Elizabeth Patton
Publicado en: Pigment Cell & Melanoma Research, Edición 32/4, 2019, Página(s) 484-485, ISSN 1755-1471
Editor: Basil Blackwell
DOI: 10.1111/pcmr.12798

Developmental disorders Journal Meeting: a collaboration between Development and Disease Models & Mechanisms.

Autores: Hooper KM, Justice MJ, Patton EE.
Publicado en: Disease Models & Mechanisms, 2022, ISSN 1754-8411
Editor: Company of Biologists
DOI: 10.1242/dmm.049268

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