Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters

Risultati finali

Physiology of normal and cystic fibrosis bronchial epithelium; Imaging assay

pH-insensitive Cl- sensor assay
iPS cells from G551D patients
Lung epithelial cells from F508del patients
iPS cells from F508del patients
Correlation of anion transport activity with mucin release in Calu-3 CFTR wt and mutant sensor cell lines
Calu-3 mutant CFTR F508del and G551D cells
Intestinal organoids from G551D patients
Anionophores in F508del and G551D mouse models
Lung epithelial cells from G551D patients
Biophysical and pharmacological characterisation of the anionophores
Intestinal organoids from F508del patients

Project Website

Pubblicazioni

Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy

Autori: Claudia Cossu, Michele Fiore, Debora Baroni, Valeria Capurro, Emanuela Caci, Maria Garcia-Valverde, Roberto Quesada, Oscar Moran
Pubblicato in: Frontiers in Pharmacology, Numero 9, 2018, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00852

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity

Autori: Elsa Hernando, Valeria Capurro, Claudia Cossu, Michele Fiore, María García-Valverde, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Oscar Moran, Olga Zegarra-Moran, Roberto Quesada
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-20708-3

Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients

Autori: Aarne Fleischer, Iván M. Lorenzo, Esther Palomino, Trond Aasen, Fernando Gómez, Miguel Servera, Víctor J. Asensio, Víctor Gálvez, Juan Carlos Izpisúa-Belmonte, Daniel Bachiller
Pubblicato in: Stem Cell Research, Numero 29, 2018, Pagina/e 1-5, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2018.03.004

5th TAT-CF Newsletter

Autori: Ángel del Pozo, Roberto Quesada
Pubblicato in: 2018
Editore: TAT-CF consortium

3rd TAT-CF Newsletter

Autori: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci
Pubblicato in: 2018
Editore: TAT-CF consortium

4th TAT-CF Newsletter

Autori: Ángel del Pozo, Roberto Quesada, Manfred Frey
Pubblicato in: 2018
Editore: TAT-CF consortium

6th TAT-CF Newsletter

Autori: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci, Manfred Frey, Daniel Bachiller, Anette Mullertz, Laszlo Puskas
Pubblicato in: 2018
Editore: TAT-CF consortium

1st TAT-CF Newsletter

Autori: Ángel del Pozo, Roberto Quesada
Pubblicato in: 2016
Editore: TAT-CF consortium

2nd TAT-CF Newsletter

Autori: Ángel del Pozo, Daniel Bachiller, Oscar Moran, Roberto Quesada
Pubblicato in: 2017
Editore: TAT-CF consortium

Biologically Active Transmembrane Anion Transporters

Autori: Roberto Quesada, Elsa Hernando, Francisco Ciruela, Vanesa Soto-Cerrato, Ricardo Pérez-Tomás, and Rosa Farràs.
Pubblicato in: Abstract book of the III Biennial Meeting of the Chemical Biology Group / XII Carbohydrate Symposium, 2016
Editore: Royal Society of Chemistry of Spain (RSEQ)

Phospholipids vesicles as convenient models to study transmembrane ion transport

Autori: Sandra Díaz, Elsa Hernando and Roberto Quesada
Pubblicato in: Abstract book of the 6th Early Stage Researchers Workshop in Nanoscience, 2016
Editore: Instituto IMDEA nanociencia

Bromination of 2, 7' bi-indolyls and quinazolin-7-ones as a key step in the synthesis of macrocyclic tetra-indolyls

Autori: Marcin Mielczarek, Mohan Bhadbhade, Rui Chen, Naresh Kumar, David St. C. Black
Pubblicato in: Abstract book of the 3rd ERC Grantees Conference, 2016
Editore: University of Groningen

An UGI/Intramolecular cyclization sequence for the synthesis of nitrogen-based heterocycles

Autori: Pablo Peña-Calleja, Pablo Pertejo, Roberto Quesada, María García-Valverde
Pubblicato in: Abstract book of the 17th Tetrahedron Symposium, 2016
Editore: Elsevier

New transmembrane anion transporters based on tetraheterocycle structures

Autori: Israel Carreira-Barral, Elsa Hernando, Roberto Quesada.
Pubblicato in: Abstract book of the 6th EuCheMS Chemistry Congress, 2016
Editore: The National Chemists Association of Spain (ANQUE)

Directed differentiation and genetic modification of novel iPS cell lines from CF patients

Autori: Daniel Bachiller, Aarne Fleischer, Esther Palomino, Ivan Lorenzo, Victor Galvez, Trond Aasen, Juan Carlos Izpisua-Belmonte, Fernando Gomez
Pubblicato in: Abstract book of the ECFS Basic Science Conference 2017, 2017
Editore: European Cystic Fibrosis Society

TAT:CF: Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters through open innovation

Autori: Angel del Pozo, Marta Pastor, Roberto Quesada, Yolanda Gil, TAT-CF Consortium
Pubblicato in: Abstract book of the the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Editore: International Rare Diseases Research Consortium

Facilitated transmembrane transport, a viable therapeutic approach for channelopathies?

Autori: Roberto Quesada, Israel Carreira, Marcin Mielczarek, María García-Valverde, Olga Zegarra, Oscar Morán, Angel del Pozo, Laszlo Puskas, Anette Mullertz, Manfred Fey and Daniel Bachiller
Pubblicato in: Abstract book of the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Editore: International Rare Diseases Research Consortium

Anion transport mechanisms through lipid bilayers by synthetic ionophores: towards a cystic fibrosis therapy

Autori: Claudia Cossu, Michele Fiore, Olga Zegarra-Moran, Valeria Capurro, Elsa Henando, Roberto Quesada and Oscar Moran
Pubblicato in: Abstract book for the XXIII Congresso Nazionale Società Italiana di Biofisica Pura e Applicata, 2016
Editore: Società Italiana di Biofisica Pura e Applicata

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