Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters

Resultado final

Physiology of normal and cystic fibrosis bronchial epithelium; Imaging assay

pH-insensitive Cl- sensor assay
iPS cells from G551D patients
Lung epithelial cells from F508del patients
iPS cells from F508del patients
Correlation of anion transport activity with mucin release in Calu-3 CFTR wt and mutant sensor cell lines
Calu-3 mutant CFTR F508del and G551D cells
Intestinal organoids from G551D patients
Anionophores in F508del and G551D mouse models
Lung epithelial cells from G551D patients
Biophysical and pharmacological characterisation of the anionophores
Intestinal organoids from F508del patients

Project Website

Publicaciones

Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy

Autores: Claudia Cossu, Michele Fiore, Debora Baroni, Valeria Capurro, Emanuela Caci, Maria Garcia-Valverde, Roberto Quesada, Oscar Moran
Publicado en: Frontiers in Pharmacology, Edición 9, 2018, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00852

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity

Autores: Elsa Hernando, Valeria Capurro, Claudia Cossu, Michele Fiore, María García-Valverde, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Oscar Moran, Olga Zegarra-Moran, Roberto Quesada
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-20708-3

Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients

Autores: Aarne Fleischer, Iván M. Lorenzo, Esther Palomino, Trond Aasen, Fernando Gómez, Miguel Servera, Víctor J. Asensio, Víctor Gálvez, Juan Carlos Izpisúa-Belmonte, Daniel Bachiller
Publicado en: Stem Cell Research, Edición 29, 2018, Página(s) 1-5, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2018.03.004

5th TAT-CF Newsletter

Autores: Ángel del Pozo, Roberto Quesada
Publicado en: 2018
Editor: TAT-CF consortium

3rd TAT-CF Newsletter

Autores: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci
Publicado en: 2018
Editor: TAT-CF consortium

4th TAT-CF Newsletter

Autores: Ángel del Pozo, Roberto Quesada, Manfred Frey
Publicado en: 2018
Editor: TAT-CF consortium

6th TAT-CF Newsletter

Autores: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci, Manfred Frey, Daniel Bachiller, Anette Mullertz, Laszlo Puskas
Publicado en: 2018
Editor: TAT-CF consortium

1st TAT-CF Newsletter

Autores: Ángel del Pozo, Roberto Quesada
Publicado en: 2016
Editor: TAT-CF consortium

2nd TAT-CF Newsletter

Autores: Ángel del Pozo, Daniel Bachiller, Oscar Moran, Roberto Quesada
Publicado en: 2017
Editor: TAT-CF consortium

Biologically Active Transmembrane Anion Transporters

Autores: Roberto Quesada, Elsa Hernando, Francisco Ciruela, Vanesa Soto-Cerrato, Ricardo Pérez-Tomás, and Rosa Farràs.
Publicado en: Abstract book of the III Biennial Meeting of the Chemical Biology Group / XII Carbohydrate Symposium, 2016
Editor: Royal Society of Chemistry of Spain (RSEQ)

Phospholipids vesicles as convenient models to study transmembrane ion transport

Autores: Sandra Díaz, Elsa Hernando and Roberto Quesada
Publicado en: Abstract book of the 6th Early Stage Researchers Workshop in Nanoscience, 2016
Editor: Instituto IMDEA nanociencia

Bromination of 2, 7' bi-indolyls and quinazolin-7-ones as a key step in the synthesis of macrocyclic tetra-indolyls

Autores: Marcin Mielczarek, Mohan Bhadbhade, Rui Chen, Naresh Kumar, David St. C. Black
Publicado en: Abstract book of the 3rd ERC Grantees Conference, 2016
Editor: University of Groningen

An UGI/Intramolecular cyclization sequence for the synthesis of nitrogen-based heterocycles

Autores: Pablo Peña-Calleja, Pablo Pertejo, Roberto Quesada, María García-Valverde
Publicado en: Abstract book of the 17th Tetrahedron Symposium, 2016
Editor: Elsevier

New transmembrane anion transporters based on tetraheterocycle structures

Autores: Israel Carreira-Barral, Elsa Hernando, Roberto Quesada.
Publicado en: Abstract book of the 6th EuCheMS Chemistry Congress, 2016
Editor: The National Chemists Association of Spain (ANQUE)

Directed differentiation and genetic modification of novel iPS cell lines from CF patients

Autores: Daniel Bachiller, Aarne Fleischer, Esther Palomino, Ivan Lorenzo, Victor Galvez, Trond Aasen, Juan Carlos Izpisua-Belmonte, Fernando Gomez
Publicado en: Abstract book of the ECFS Basic Science Conference 2017, 2017
Editor: European Cystic Fibrosis Society

TAT:CF: Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters through open innovation

Autores: Angel del Pozo, Marta Pastor, Roberto Quesada, Yolanda Gil, TAT-CF Consortium
Publicado en: Abstract book of the the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Editor: International Rare Diseases Research Consortium

Facilitated transmembrane transport, a viable therapeutic approach for channelopathies?

Autores: Roberto Quesada, Israel Carreira, Marcin Mielczarek, María García-Valverde, Olga Zegarra, Oscar Morán, Angel del Pozo, Laszlo Puskas, Anette Mullertz, Manfred Fey and Daniel Bachiller
Publicado en: Abstract book of the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Editor: International Rare Diseases Research Consortium

Anion transport mechanisms through lipid bilayers by synthetic ionophores: towards a cystic fibrosis therapy

Autores: Claudia Cossu, Michele Fiore, Olga Zegarra-Moran, Valeria Capurro, Elsa Henando, Roberto Quesada and Oscar Moran
Publicado en: Abstract book for the XXIII Congresso Nazionale Società Italiana di Biofisica Pura e Applicata, 2016
Editor: Società Italiana di Biofisica Pura e Applicata

Resultado final

Publicaciones

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