Objetivo New materials are now opening clinical treatments in which a temporary scaffold is used to support regeneration of healthy tissue. The specific need that inspires our research is for thinner and stronger bioresorbable vascular scaffolds (BVS) for coronary heart disease. BVS are poised to replace metal stents due to the excellent clinical outcomes: beyond keeping the vessel open during the first six months after surgery, the BVS leaves behind a healthy blood vessel after the scaffold is gone, being completely absorbed by the body approximately two years after surgery. The material that has achieved clinical approval for BVS is poly(L-lactic acid), PLLA. It is not as strong and stiff as metals, so the scaffold is three times thicker than the metal stents, making it more difficult for surgeons to move through arteries to reach the site of the lesion. Thinner Scaffolds that can be seen by x-ray imaging during surgery would facilitate adoption of the technology and benefit thousands of patients in the EU and US. The proposed Action will provide the fundamental understanding needed to reinforce PLLA by tungsten disulphide (WS2) nanotubes to achieve both the strength and x-ray opacity needed. Improving materials for BVS requires an interdisciplinary approach by materials science, polymer processing, and bioengineering. The proposed Action will connect EU scientists with a polymer scientist at Caltech in the US who has specialized knowledge of PLLA BVS and the relevant structure-processing-property relationships (Kornfield). European scientists bring expertise in WS2 nanotubes that are powerful additives for enhancing polymer properties (Di Luccio), compounding polymers with nanotubes (McNally), biaxial stretching to induce strength and orientation in polymers (Menary), multiscale modeling to connect nanoscale to continuum scale (Figiel), multimethod characterization of structure in nanocomposites (Schiller) and the response of cells to nanoparticles (Kornfield). Ámbito científico natural scienceschemical sciencesinorganic chemistrytransition metalsnatural scienceschemical sciencespolymer sciencesengineering and technologynanotechnologynano-materialsnatural sciencescomputer and information sciencescomputational sciencemultiphysicsengineering and technologymaterials engineeringnanocomposites Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Tema(s) MSCA-RISE-2015 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Convocatoria de propuestas H2020-MSCA-RISE-2015 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinador AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE Aportación neta de la UEn € 139 500,00 Dirección LUNGOTEVERE GRANDE AMMIRAGLIO THAON DI REVEL 76 00196 Roma Italia Ver en el mapa Región Centro (IT) Lazio Roma Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 157 500,00 Participantes (2) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo THE QUEEN'S UNIVERSITY OF BELFAST Reino Unido Aportación neta de la UEn € 135 000,00 Dirección UNIVERSITY ROAD LANYON BUILDING BT7 1NN Belfast Ver en el mapa Región Northern Ireland Northern Ireland Belfast Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 153 000,00 THE UNIVERSITY OF WARWICK Reino Unido Aportación neta de la UEn € 67 500,00 Dirección Kirby Corner Road - University House CV4 8UW Coventry Ver en el mapa Región West Midlands (England) West Midlands Coventry Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 90 000,00 Socios (1) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo Socio Las organizaciones asociadas contribuyen a la aplicación de la acción, pero no firman el acuerdo de subvención. CALIFORNIA INSTITUTE OF TECHNOLOGYCORP Estados Unidos Aportación neta de la UEn € 0,00 Dirección EAST CALIFORNIA BOULEVARD 1200 91125 Pasadena Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 58 500,00