Resultado final Documents, reports (21) Report on effects of PRRSV infection on S. suis interaction in lung slices Report on effects of PRRSV infection on S. suis interaction in precision cut lung slices Report on cost of S. suis infection at the farm level Report on cost of S suis infection at the farm level Report on the ‘cornerstone’ species that are predicted to stabilize microbial communities in healthy piglets Report on ‘cornerstone’ taxa that are predicted to stabilize microbial communities in healthy piglets and species that might protect piglets against S. suis and other pathogens including viruses based on co-occurrence networks Report on the impact of PRRSV in vivo infection on S. suis co-infection Report on the impact of PRRSV in vivo infection on S suis coinfection Report on retrospective data on incidence of S. suis infection in humans in the partner countries Report on estimated economic losses due to S. suis infection per country Report on estimated economic losses due to S suis infection per country Identification of genes required for fitness under in vivo mimicking conditions by Tn-Seq TnSeq technique applied to conditions mimicking those in vivo to identify conditionally essential genes Report on virulence of selected mutants in porcine infection models. 2 most relevant gene mutants verified in virulence in porcine infection model using data from virulence studies in vitro Report on identified risk factors for S. suis infection of pigs Report on identified risk factors for S suis infection of pigs Report on the effects of SIV on bacterial adherence and colonization at respiratory epithelia using PCLS and ALI cultures of airway epithelial cells Report on precise definition of an immune status conferring colonisation resistance against S. suis Report on precise definition of an immune status conferring colonisation resistance against S suis Report on the precise definition of porcine immune responses to virulent and non-virulent S. suis Report on the precise definition of porcine immune responses to virulent and nonvirulent S suis Report on the burden of (zoonotic) disease estimates in humans in the EU Report on the burden of zoonotic disease estimates in humans in the EU Report on bacterial genes involved in S. suis/SIV interactions in epithelial cells RReport on S. suis gene expression in blood/CSF vs artificial culture media Report on gene expression of at least one strain of S. suis under conditions mimicking those in vivo. Information utilised in vaccine and virulence studies. Report on the deep analysis of the microbiota composition in healthy and S. suis-diseased piglets characterise diversity, composition and functional capacities of microbiota and key abundant taxa associated with healthy and disease-associated microbiota communities. Report of retrospective data on incidence of S. suis infection in pigs in the partner countries Report on virulence of mutants Report on the growth and virulence of 4 to 20 mutants in vitro Report on host genes important for the innate immune response against S. suis Report on host genes important for the innate immune response against S suis Report on the burden of disease estimates in pigs for the partner countries Report on PRRSV /SIV on innate immunity of the lower respiratory tract Report on PRRSV SIV on innate immunity of the lower respiratory tract Demonstrators, pilots, prototypes (1) Standardised diagnostic tests for identification of disease-causing and non-disease causing strains of S. suis in pure culture and in pig samples Websites, patent fillings, videos etc. (6) Establishment of Project website and information share point Public Science Event 1 Presentations to the public at National Science Events or at open days or local science events for the general public Public Science Event 3 1 or 2 presentations to the public at National Science Events or at open days or local science events for the general pub Public Science Event 4 1 or 2 presentations to the public at National Science Events or at open days or local science events for the general public Public Science Event 2 1 or 2 presentations to the public at National Science Events or at open days or local science events for the general pub Public Science Event 5 1 or 2 presentations to the public at National Science Events or at open days or local science events for the general pub Other (5) Genome database containing core genome, meta data, virulence, serotype, MLST, antibiotic resistance Bioinformatic analyses of S. suis genome sequences in database Collection of isolates Multinational collection of S. suis isolates for sequencing Characterisation of Type I and Type III phase variable systems Characterisation of phase variable restriction modification systems Mutants constructed in selected candidate virulence genes in S. suis strains Mutants constructed in selected candidate virulence genes made in two virulent strains of S. suis. Sequencing of isolate collection Genome sequencing of around 90% S. suis isolates completed Publicaciones Peer reviewed articles (11) Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain Autores: Neila-Ibáñez, Carlos; Brogaard, Louise; Pailler-García, Lola; Martínez, Jorge; Segalés, Joaquim; Segura, Mariela; Heegaard, Peter M. H.; Aragon, Virginia Publicado en: Neila-Ibanez , C , Brogaard , L , Pailler-Garcia , L , Martinez , J , Segales , J , Segura , M , Heegaard , P M H & Aragon , V 2021 , ' Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain ' , Veterinary Research , vol. 52 , 145 . https://doi.org/10.1186/s13567-021-01013-w, Issue 15, 2021, ISSN 0928-4249 Editor: BioMed Central DOI: 10.1186/s13567-021-01013-w Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota Autores: Florencia Correa-Fiz, Carlos Neila-Ibáñez, Sergio López-Soria, Sebastian Napp, Blanca Martinez, Laia Sobrevia, Simon Tibble, Virginia Aragon, Lourdes Migura-Garcia Publicado en: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Editor: Nature Publishing Group DOI: 10.1038/s41598-020-77313-6 Stochastic Assessment of the Economic Impact of Streptococcus suis-Associated Disease in German, Dutch and Spanish Swine Farms Autores: Carlos Neila-Ibáñez1,2, Jordi Casal1,2,3, Isabel Hennig-Pauka4, Norbert Stockhofe-Zurwieden5, Marcelo Gottschalk6, Lourdes Migura-García1,2, LolaPailler-García1,2 andSebastiánNapp1,2* Publicado en: Frontiers in Veterinary Science, 2021, ISSN 2297-1769 Editor: Frontiers DOI: 10.3389/fvets.2021.676002 Streptococcus suis Induces Expression of Cyclooxygenase-2 in Porcine Lung Tissue Autores: Muriel Dresen; Josephine Schenk; Yenehiwot Berhanu Weldearegay; Désirée Vötsch; Wolfgang Baumgärtner; Peter Valentin-Weigand; Andreas Nerlich Publicado en: Microorganisms, Issue 1, 2021, ISSN 2076-2607 Editor: MDPI DOI: 10.17169/refubium-30219 Identification of Streptococcus suis putative zoonotic virulence factors: a systematic review and genomic meta-analysis Autores: Thomas J. Roodsant, Boas C.L. van der Putten, Sara M. Tamminga, Constance Schultsz, Kees C.H. van der Ark Publicado en: Virulence, 2021, Page(s) 0-0, ISSN 2150-5594 Editor: Landes Bioscience DOI: 10.1080/21505594.2021.1985760 Active Human and Porcine Serum Induce Competence for Genetic Transformation in the Emerging Zoonotic Pathogen Streptococcus suis Autores: Maria Laura Ferrando, Alex Gussak, Saskia Mentink, Marcela Fernandez Gutierrez, Peter van Baarlen, Jerry Mark Wells Publicado en: Pathogens, Issue 10/2, 2021, Page(s) 156, ISSN 2076-0817 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pathogens10020156 Identification of conditionally essential genes for Streptococcus suis infection in pigs Autores: Jesús Arenas, Aldert Zomer, Jose Harders-Westerveen, Hester J. Bootsma, Marien I. De Jonge, Norbert Stockhofe-Zurwieden, Hilde E. Smith, Astrid De Greeff Publicado en: Virulence, Issue 11/1, 2020, Page(s) 446-464, ISSN 2150-5594 Editor: Landes Bioscience DOI: 10.1080/21505594.2020.1764173 Five Complete Genome Sequences Spanning the Dutch Streptococcus suis Serotype 2 and Serotype 9 Populations Autores: Boas C. L. van der Putten, Thomas J. Roodsant, Martin A. Haagmans, Constance Schultsz, Kees C. H. van der Ark Publicado en: Microbiology Resource Announcements, Issue 9/6, 2020, ISSN 2576-098X Editor: ASM Journals DOI: 10.1128/mra.01439-19 Viral Coinfection Replaces Effects of Suilysin on Streptococcus suis Adherence to and Invasion of Respiratory Epithelial Cells Grown under Air-Liquid Interface Conditions Autores: Fandan Meng, Jie Tong, Désirée Vötsch, Ju-Yi Peng, Xuehui Cai, Maren Willenborg, Georg Herrler, Nai-Huei Wu, Peter Valentin-Weigand Publicado en: Infection and Immunity, Issue 87/8, 2019, ISSN 0019-9567 Editor: American Society for Microbiology DOI: 10.1128/iai.00350-19 Environmental and maternal factors shaping tonsillar microbiota development in piglets Autores: Fredriksen S, Guan X, Boekhorst J, Molist F, van Baarlen P, Wells JM Publicado en: BMC, 2022, ISSN 1471-2180 Editor: BioMed Central DOI: 10.1186/s12866-022-02625-8 Identification and characterization of the cell division protein MapZ from Streptococcus suis. Autores: Muriel Dresen; Manfred Rohde; Jesús Arenas; Astrid de Greeff; Andreas Nerlich; Andreas Nerlich; Peter Valentin-Weigand Publicado en: MicrobiologyOpen, 10(5), Issue 17, 2021, ISSN 2045-8827 Editor: John Wiley and Sons Inc. DOI: 10.1002/mbo3.1234 Buscando datos de OpenAIRE... Se ha producido un error en la búsqueda de datos de OpenAIRE No hay resultados disponibles
