Objectif Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to completely replace conventional antibody technology within medical diagnostics and basic life science research. In a multidisciplinary approach combining basic science, protein engineering and computational prediction, Pre-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market, after forty years still based on monoclonal antibodies (mAbs) to detect biomolecules, when 50% of all commercial reagent mAbs have been shown to not function correctly. By combining information science with directed evolution, PRe-ART will ultimately create an encyclopedia of pre-designed and experimentally pre-selected modules (like biological Lego bricks) that may be combined, without any further experiment, to generate unique binding molecules that function as antibody replacements. The PRe-ART vision is that mAbs for many applications in biological research will be replaced over the course of a decade by these designer molecules, with the potential to completely disrupt the industry selling low-quality commercial animal-derived reagent antibodies, and thus create a major new technology for biological research. Thus, PRe-ART will ultimately contribute not only to the health and wellbeing of the EU citizen through improved diagnostic capability, but also to the economy of the EU through the development of myriad detection products, enabled by this foundational platform technology. The interdisciplinary PRe-ART project will achieve this goal by bringing together three leading labs from different fields, two of which are lead by women PIs, whose joint efforts will achieve this breakthrough S&T target. The PRe-ART project thus closely addresses all specific challenges of the call. Champ scientifique engineering and technologymaterials engineeringcrystalsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinssocial sciencespolitical sciencespolitical transitionsrevolutionsnatural scienceschemical sciencesorganic chemistryamines Mots‑clés Proteomics Protein Design Antibodies Armadillo Repeat Proteins Computation Molecular Modeling ProxiMAX Biological Engineering Biotechnology Directed Evolution Diagnostics Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Thème(s) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Appel à propositions H2020-FETOPEN-2016-2017 Voir d’autres projets de cet appel Sous appel H2020-FETOPEN-1-2016-2017 Régime de financement RIA - Research and Innovation action Coordinateur UNIVERSITAT ZURICH Contribution nette de l'UE € 1 428 750,00 Adresse RAMISTRASSE 71 8006 Zurich Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 428 750,00 Participants (2) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire ASTON UNIVERSITY Royaume-Uni Contribution nette de l'UE € 1 189 375,00 Adresse ASTON TRIANGLE B4 7ET Birmingham Voir sur la carte Région West Midlands (England) West Midlands Birmingham Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 189 375,00 UNIVERSITAT BAYREUTH Allemagne Contribution nette de l'UE € 970 000,00 Adresse UNIVERSITATSSTRASSE 30 95447 Bayreuth Voir sur la carte Région Bayern Oberfranken Bayreuth, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 970 000,00
