Obiettivo Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to completely replace conventional antibody technology within medical diagnostics and basic life science research. In a multidisciplinary approach combining basic science, protein engineering and computational prediction, Pre-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market, after forty years still based on monoclonal antibodies (mAbs) to detect biomolecules, when 50% of all commercial reagent mAbs have been shown to not function correctly. By combining information science with directed evolution, PRe-ART will ultimately create an encyclopedia of pre-designed and experimentally pre-selected modules (like biological Lego bricks) that may be combined, without any further experiment, to generate unique binding molecules that function as antibody replacements. The PRe-ART vision is that mAbs for many applications in biological research will be replaced over the course of a decade by these designer molecules, with the potential to completely disrupt the industry selling low-quality commercial animal-derived reagent antibodies, and thus create a major new technology for biological research. Thus, PRe-ART will ultimately contribute not only to the health and wellbeing of the EU citizen through improved diagnostic capability, but also to the economy of the EU through the development of myriad detection products, enabled by this foundational platform technology. The interdisciplinary PRe-ART project will achieve this goal by bringing together three leading labs from different fields, two of which are lead by women PIs, whose joint efforts will achieve this breakthrough S&T target. The PRe-ART project thus closely addresses all specific challenges of the call. Campo scientifico engineering and technologymaterials engineeringcrystalsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinssocial sciencespolitical sciencespolitical transitionsrevolutionsnatural scienceschemical sciencesorganic chemistryamines Parole chiave Proteomics Protein Design Antibodies Armadillo Repeat Proteins Computation Molecular Modeling ProxiMAX Biological Engineering Biotechnology Directed Evolution Diagnostics Programma(i) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Argomento(i) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Invito a presentare proposte H2020-FETOPEN-2016-2017 Vedi altri progetti per questo bando Bando secondario H2020-FETOPEN-1-2016-2017 Meccanismo di finanziamento RIA - Research and Innovation action Coordinatore UNIVERSITAT ZURICH Contribution nette de l'UE € 1 428 750,00 Indirizzo RAMISTRASSE 71 8006 Zurich Svizzera Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Zürich Zürich Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 428 750,00 Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto ASTON UNIVERSITY Regno Unito Contribution nette de l'UE € 1 189 375,00 Indirizzo ASTON TRIANGLE B4 7ET Birmingham Mostra sulla mappa Regione West Midlands (England) West Midlands Birmingham Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 189 375,00 UNIVERSITAT BAYREUTH Germania Contribution nette de l'UE € 970 000,00 Indirizzo UNIVERSITATSSTRASSE 30 95447 Bayreuth Mostra sulla mappa Regione Bayern Oberfranken Bayreuth, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 970 000,00