Cel Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to completely replace conventional antibody technology within medical diagnostics and basic life science research. In a multidisciplinary approach combining basic science, protein engineering and computational prediction, Pre-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market, after forty years still based on monoclonal antibodies (mAbs) to detect biomolecules, when 50% of all commercial reagent mAbs have been shown to not function correctly. By combining information science with directed evolution, PRe-ART will ultimately create an encyclopedia of pre-designed and experimentally pre-selected modules (like biological Lego bricks) that may be combined, without any further experiment, to generate unique binding molecules that function as antibody replacements. The PRe-ART vision is that mAbs for many applications in biological research will be replaced over the course of a decade by these designer molecules, with the potential to completely disrupt the industry selling low-quality commercial animal-derived reagent antibodies, and thus create a major new technology for biological research. Thus, PRe-ART will ultimately contribute not only to the health and wellbeing of the EU citizen through improved diagnostic capability, but also to the economy of the EU through the development of myriad detection products, enabled by this foundational platform technology. The interdisciplinary PRe-ART project will achieve this goal by bringing together three leading labs from different fields, two of which are lead by women PIs, whose joint efforts will achieve this breakthrough S&T target. The PRe-ART project thus closely addresses all specific challenges of the call. Dziedzina nauki engineering and technologymaterials engineeringcrystalsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinssocial sciencespolitical sciencespolitical transitionsrevolutionsnatural scienceschemical sciencesorganic chemistryamines Słowa kluczowe Proteomics Protein Design Antibodies Armadillo Repeat Proteins Computation Molecular Modeling ProxiMAX Biological Engineering Biotechnology Directed Evolution Diagnostics Program(-y) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Temat(-y) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Zaproszenie do składania wniosków H2020-FETOPEN-2016-2017 Zobacz inne projekty w ramach tego zaproszenia Szczegółowe działanie H2020-FETOPEN-1-2016-2017 System finansowania RIA - Research and Innovation action Koordynator UNIVERSITAT ZURICH Wkład UE netto € 1 428 750,00 Adres RAMISTRASSE 71 8006 Zurich Szwajcaria Zobacz na mapie Region Schweiz/Suisse/Svizzera Zürich Zürich Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 428 750,00 Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko ASTON UNIVERSITY Zjednoczone Królestwo Wkład UE netto € 1 189 375,00 Adres ASTON TRIANGLE B4 7ET Birmingham Zobacz na mapie Region West Midlands (England) West Midlands Birmingham Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 189 375,00 UNIVERSITAT BAYREUTH Niemcy Wkład UE netto € 970 000,00 Adres UNIVERSITATSSTRASSE 30 95447 Bayreuth Zobacz na mapie Region Bayern Oberfranken Bayreuth, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 970 000,00
