Objective Organocopper reagents are of importance in organic synthesis because of their versatile reactivity pattern including cross coupling and 1,4-conjugate addition as well as SN2 and SN2' displacement reactions. Their use has made available an overwhelming number of new, and often very short, synthetic pathways to valuable molecules like prostanoids, pheromones, antitumour compounds and fragrance compounds.As many of these target molecules are chiral, a direct need for control of the absolute configuration in their synthesis emerged for environmental and biological reasons. It is this aspect that has been addressed in the present work.Novel types of ortho-functionalised arylcopper compounds were synthesised and structurally characterised. A new chiral arenethiolatecopper(I) compound was synthesised, which appeared to be a promising catalyst (9 mole %) for the enantioselective 1,4-addition of methylmagnesium halide to benzylideneacetone. Unprecedented selective exchange reactions between organolithium, organocopper and organomagnesium reagents and arenethiolatecopper(I) compounds have been established and structurally characterised. Fields of science natural scienceschemical sciencescatalysis Programme(s) FP1-STIMULATION 1C - Plan (EEC) to stimulate European scientific and technical cooperation and interchange, 1985-1988 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator WISE & MUNRO LEARNING RESEARCH EU contribution No data Address 8,Azaleastraat 85 2565 CD DEN HAAG Netherlands See on map Links Website Opens in new window Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE LOUIS PASTEUR, STRASBOURG 1 France EU contribution No data Address Rue Blaise Pascal 4 67070 STRASBOURG See on map Total cost No data
