Objectif Organocopper reagents are of importance in organic synthesis because of their versatile reactivity pattern including cross coupling and 1,4-conjugate addition as well as SN2 and SN2' displacement reactions. Their use has made available an overwhelming number of new, and often very short, synthetic pathways to valuable molecules like prostanoids, pheromones, antitumour compounds and fragrance compounds.As many of these target molecules are chiral, a direct need for control of the absolute configuration in their synthesis emerged for environmental and biological reasons. It is this aspect that has been addressed in the present work.Novel types of ortho-functionalised arylcopper compounds were synthesised and structurally characterised. A new chiral arenethiolatecopper(I) compound was synthesised, which appeared to be a promising catalyst (9 mole %) for the enantioselective 1,4-addition of methylmagnesium halide to benzylideneacetone. Unprecedented selective exchange reactions between organolithium, organocopper and organomagnesium reagents and arenethiolatecopper(I) compounds have been established and structurally characterised. Champ scientifique natural scienceschemical sciencescatalysis Programme(s) FP1-STIMULATION 1C - Plan (EEC) to stimulate European scientific and technical cooperation and interchange, 1985-1988 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur WISE & MUNRO LEARNING RESEARCH Contribution de l’UE Aucune donnée Adresse 8,Azaleastraat 85 2565 CD DEN HAAG Pays-Bas Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITE LOUIS PASTEUR, STRASBOURG 1 France Contribution de l’UE Aucune donnée Adresse Rue Blaise Pascal 4 67070 STRASBOURG Voir sur la carte Coût total Aucune donnée
