The event broadcasted the first part live through the social networks of the VES4US project. The five projects funded by the European Commission's FET-OPEN Programme presented themselves during the first part of the event. The session was introduced by Giuseppe Martini, FET expert and founder of Bioestella who spoke about Horizon Europe perspectives, and closed by Barbara Gerratana, project officer of INDEX and VES4US who talked about the new EIC and its offerings. About 1st EVs Clustering Event in Palermo The day continued with two round tables on two hot topics for EVs research: EVs-production of High-Grade formulations: technologies and sources, sustainable, appealing for the society and environment and Applications of EVs: biomedical use, nutraceutics, cosmetics. And it finished with a THINK OUT OF THE BOX session in which the invited external panellists from Biostella, Nanoview BioSciences, IntrepidaBio, Anasysta and Fondazione Ri.MED exchanged views on the EVs market and then judged the exploitation activities and innovation stories of the five FET projects: INDEX, VES4US, EVFOUNDRY, GLADIATOR and MINDGAP. This event is of great importance because it is the first in which projects financed by FET-Open join with the same theme, the Extracellular Vesicles and their sound relevance in the EU research agenda. The main action of the day was the signing of the letter of intent by the 5 coordinators of the project in which: "The undersigned coordinators of the 5 running FET-Open projects featuring extracellular vesicles (EVs) science and technology […] commit to deliver a shared "EV manifesto" by November 31st 2019 highlighting the non-incremental, foundational promises of these Precision Nanoparticles 2.0 which are poised to EVs are reshaping our perspective on life sciences, environment and public health." Taking the baton from this first event, next year the 2nd EVs Clustering Event will be hosted by the MINDGAP project in Coimbra (Portugal).