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The Extracellular Vesicle Foundry

Objective

Extracellular vesicles (EVs) are natural cell-derived nanoparticles containing bioactive proteins and RNAs, which are newly recognized as the universal agents of intercellular and inter-organismal communication, in both normal and pathological processes.
EVs are reshaping our perspective on life sciences, environment and public health. They are under intensive investigation as early disease multi-biomarkers, while EV-based personalized therapeutic agents and vaccines have produced enticing results in early-phase clinical trials. However, EV exploitation is not supported by current manufacturing methods, which are inadequate in terms of purity and reproducibility or yield, time and cost.
evFOUNDRY targets a breakthrough technology able to streamline production of therapeutic EVs from sustainable sources, drawing the baseline for future EV bioprocessing, which is necessary for effective EV medical translation (large clinical trials and regulatory initiatives) and provides access to new EV applications (nanotechnology, nutraceuticals, cosmeceuticals, veterinary).
To meet the challenge, evFOUNDRY will unravel how EVs and EV fluids interact with surfaces and leverage it to develop the first device for continuous production of high-grade EVs from milk and parasites, which are the most promising scalable sources of EVs with immune modulatory properties.
Major objectives include: (i) to determine the compositional, structural and colloidal properties of EVs that control their interaction with surfaces; (ii) to engineer nanostructured surfaces integrated in microfluidic devices for separation of EV populations that are homogeneous in size and/or membrane properties from bovine milk and Ascaris incubation media; (iii) to design an integrated modular-system for the reproducible separation of these EVs under continuous flow; (iv) to implement a lab-scale prototype for the continuous production of quality-compliant immune modulatory EVs.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/genetics and heredity/rna
  • /engineering and technology/nanotechnology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Funding Scheme

RIA - Research and Innovation action
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Coordinator

CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE
Address
Via Della Lastruccia 3
50019 Firenze
Italy
Activity type
Research Organisations
EU contribution
€ 639 375

Participants (5)

LUNDS UNIVERSITET
Sweden
EU contribution
€ 401 065
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 449 976,25
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
AARHUS UNIVERSITET
Denmark
EU contribution
€ 417 405
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 400 695
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
HANSABIOMED LIFE SCIENCES OU
Estonia
EU contribution
€ 418 000
Address
Maealuse Tn 2/1, Harju Maakond, Mustamae Linnaosa
12618 Tallinn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)