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High Resolution Microscopy in the DNA Damage Response

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Powerful microscopy identifies DNA damage

Powerful microscopy identifies DNA damage

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Understanding damage done to DNA is important for advancing health and scientific research. One way of achieving this is through powerful microscopy to observe how cells constantly work on repairing DNA. The EU-funded training network 'High resolution microscopy in the DNA damage response' (IMAGE DDR) helped address the lack of researchers who can exploit advanced microscopy to study DNA damage response. The project brought together several laboratories and an industrial partner in the field. The goal was to provide 10 early-stage researchers (ESRs) with advanced training in imaging methodology beyond already established genetics techniques and biochemistry. It provided cross-disciplinary training to equip students with strong career advantages and prospects. To achieve its aims, IMAGE DDR combined two laboratories with complementary expertise, namely imaging and traditional biology. It enabled students to work between disciplines within a wider network, sharing experiences and technical expertise. The training was supported by workshops on advanced microscopy and studies on the methodologies behind the discipline. The major project achievement involved recruiting 10 ESRs, 6 of whom were women. Several fellows have completed the training already and have secured postdoctoral positions, while others are currently working on their PhDs. With this in mind, the project was deemed an important success, providing excellent employment positions and opportunities to the trainees and offering continuous support within a strong network of collaborators. The project has helped strengthen the European Research Area (ERA) through multidisciplinary expertise that will help exploit biotechnology in the future. This is set to contribute to research in treatment of major diseases such as cancer.

Keywords

Microscopy, DNA damage, imaging, biology, genetics, biochemistry, cancer

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