'Cell Senescence in Cancer and Ageing', Cambridge, UK
Cell senescence is a stable arrest of cell proliferation. It is initiated by a variety of molecular triggers including activated oncogenes and excess rounds of cell division. Senescent cells secrete a cocktail of inflammatory and stromal regulators (the senescence-associated secretory phenotype) that influences the behaviour of neighbouring cells, including immune cells.
Compelling evidence now indicates that cell senescence is a potent tumour suppression mechanism. Scientists know senescence is an irreversible stage in the life of the cell but are intent upon learning much more about this process. Senescence may be an underlying cause of ageing that evolved to prevent the uncontrolled growth of cells - what we know as cancer.
The conference will be an opportunity for researchers investigating mechanisms of cell senescence, the impact of senescence on cancer and ageing and avenues to exploit senescence in cancer and disease therapies.For further information, please visit:
http://registration.hinxton.wellcome.ac.uk/display_info.asp?id=342(opens in new window)