Project description Integrated biomedical information for better health Show the project objective Hide the project objective We propose to develop a Virtual Laboratory for Infectious Diseases that facilitates medical knowledge discovery and decision support for e.g. HIV drug resistance. Large, high quality, clinical and patient databases have become available which can be used to relate genotype to drug-susceptibility phenotype. The relevant data has two main characteristics: it spans all temporal and spatial scales from the genome up to the clinical data; it is inherently distributed over various sources (virological-, clinical- and drugs-databases) that change dynamically over time. Using a Grid-based service oriented architecture, we `vertically¿ integrate the biomedical information from viruses (proteins and mutations), patients (e.g. viral load) and literature (drug resistance experiments), resulting in a rule-based decision support system for drug ranking. The Virtual Laboratory supports tools for statistical analysis, visualization, modeling and simulation, to predict the temporal virological and immunological response of viruses with complex mutation patterns to drug therapy. The Virtual Laboratory provides the medical doctors with a decision support system to rank drugs targeted at patients. It provides the virologists with an advanced environment to study trends on an individual, population and epidemiological level. By virtualizing the hardware, compute infrastructure, and databases, the virtual laboratory is a user friendly environment, with tailored workflow templates to harness and automate such diverse tasks as data archiving, data integration, data mining and analysis, and modeling and simulation. HIV drug resistance is one of the few areas in medicine where genetic information is widely used for a considerable number of years. Large numbers of complex genetic sequences are available, in addition to clinical data. ViroLab offers a unique opportunity as a blueprint for the potentially many diseases where genetic information becomes important in future years. Fields of science natural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancenatural sciencescomputer and information sciencessoftwaresoftware applicationsvirtual reality Programme(s) FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006). Topic(s) IST-2004-2.4.11 - Integrated biomedical information for better health Call for proposal FP6-2004-IST-4 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator UNIVERSITEIT VAN AMSTERDAM EU contribution € 812 652,00 Address Kruislaan 403 1098 SJ Amsterdam Netherlands See on map Activity type Higher or Secondary Education Establishments Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 179 648,00 Address OUDE MARKT 13 3000 LEUVEN See on map Activity type Higher or Secondary Education Establishments Total cost No data UNIVERSITAET STUTTGART Germany EU contribution € 488 394,00 Address KEPLERSTRASSE 7 70174 STUTTGART See on map Activity type Higher or Secondary Education Establishments Total cost No data FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA Spain EU contribution € 130 100,00 Address CTRA DE CANYET S/N UNIVERSITY HOSPITAL GERMANS TRIAS I PU \\* 08916 BARCELONA See on map Activity type Research Organisations Total cost No data EOTVOS LORAND TUDOMANYEGYETEM Hungary EU contribution € 141 500,00 Address EGYETEM TER 1-3 1053 BUDAPEST See on map Activity type Higher or Secondary Education Establishments Total cost No data UNIVERSITA CATTOLICA DEL SACRO CUORE Italy EU contribution € 130 100,00 Address LARGO GEMELLI 1 20123 MILANO See on map Total cost No data UNIVERSITA DEGLI STUDI DI BRESCIA Italy EU contribution € 130 100,00 Address PIAZZA MERCATO 15 25121 BRESCIA See on map Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Participation ended Netherlands EU contribution € 270 744,00 Address HEIDELBERGLAAN 100 3584 CX UTRECHT See on map Activity type Higher or Secondary Education Establishments Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 274 356,00 Address S GRAVENDIJKWAL 3015 CE ROTTERDAM See on map Activity type Other Total cost No data VIROLOGY EDUCATION B.V. Participation ended Netherlands EU contribution € 22 246,00 Address MALIEBAAN 24-26 3581 CP UTRECHT See on map Activity type Other Total cost No data AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE Poland EU contribution € 394 200,00 Address UL. NAWOJKI 11 30-950 KRAKOW See on map Activity type Higher or Secondary Education Establishments Total cost No data GRIDWISETECH SP ZOO Poland EU contribution € 134 800,00 Address UL. BOLESLAWA CHROBREGO 28/4 31428 KRAKOW See on map Total cost No data GRIDWISE TECHNOLOGIES PAWEL PLASZCZAK Participation ended Poland EU contribution € 0,00 Address AL. 3 MAJA 9/103 30 062 KRAKOW See on map Activity type Other Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution € 226 000,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Total cost No data
