Project description
Integrated biomedical information for better health
We propose to develop a Virtual Laboratory for Infectious Diseases that facilitates medical knowledge discovery and decision support for e.g. HIV drug resistance. Large, high quality, clinical and patient databases have become available which can be used to relate genotype to drug-susceptibility phenotype. The relevant data has two main characteristics: it spans all temporal and spatial scales from the genome up to the clinical data; it is inherently distributed over various sources (virological-, clinical- and drugs-databases) that change dynamically over time. Using a Grid-based service oriented architecture, we `vertically¿ integrate the biomedical information from viruses (proteins and mutations), patients (e.g. viral load) and literature (drug resistance experiments), resulting in a rule-based decision support system for drug ranking. The Virtual Laboratory supports tools for statistical analysis, visualization, modeling and simulation, to predict the temporal virological and immunological response of viruses with complex mutation patterns to drug therapy. The Virtual Laboratory provides the medical doctors with a decision support system to rank drugs targeted at patients. It provides the virologists with an advanced environment to study trends on an individual, population and epidemiological level. By virtualizing the hardware, compute infrastructure, and databases, the virtual laboratory is a user friendly environment, with tailored workflow templates to harness and automate such diverse tasks as data archiving, data integration, data mining and analysis, and modeling and simulation. HIV drug resistance is one of the few areas in medicine where genetic information is widely used for a considerable number of years. Large numbers of complex genetic sequences are available, in addition to clinical data. ViroLab offers a unique opportunity as a blueprint for the potentially many diseases where genetic information becomes important in future years.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences computer and information sciences data science data mining
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
- natural sciences computer and information sciences software software applications virtual reality
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-IST-4
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1098 SJ Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.