Photoactivatable Drug Releasing Implants

Project Information

PADRE

Grant agreement ID: 101001016

DOI

10.3030/101001016

EC signature date 1 February 2021

Start date 1 May 2021

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 962 477,00

EU contribution

€ 1 962 477,00

Coordinated by

HELSINGIN YLIOPISTO
Finland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

730 nm Light‐Induced Cleavage of BODIPY Photocages via Entropy‐Driven Triplet Sensitization

Author(s): Jussi Isokuortti, Kaiqi Long, Zahra Gounani, Yichi Zhang, Omar Alsaedy, Weiping Wang, Timo Laaksonen, Nikita A. Durandin
Published in: Advanced Optical Materials, Issue 12, 2025, ISSN 2195-1071
Publisher: Wiley
DOI: 10.1002/adom.202400310

Nanoparticle release from anionic nanocellulose hydrogel matrix

Author(s): Vili-Veli Auvinen, Patrick Laurén, Boxuan Shen, Jussi Isokuortti, Nikita Durandin, Tatu Lajunen, Veikko Linko, Timo Laaksonen
Published in: Cellulose, Issue 29, 2022, Page(s) 9707-9717, ISSN 0969-0239
Publisher: Blackie Academic & Professional
DOI: 10.1007/s10570-022-04875-1

Electron‐Deficient Phenanthrenequinone Derivative for Photoactivated Hydrogen Atom Transfer Mediated Oxidation of Secondary Alcohols

Author(s): Juulia Talvitie, Iida Alanko, Anna Lenarda, Nikita Durandin, Nikolai Tkachenko, Martin Nieger, Juho Helaja
Published in: ChemPhotoChem, Issue 7, 2025, Page(s) e202300107, ISSN 2367-0932
Publisher: Wiley
DOI: 10.1002/cptc.202300107

Traceless Photopolymerization with Non‐Pulsed Red Light Enables 3D‐Printable Cell‐Laden Hydrogels

Author(s): Ali Eftekhari, Kelsey Rianne de Graaf, Ekaterina Takmakova, Hatai Jongprasitkul, Alexander Efimov, Sanna Turunen, Andrew Kerr, Minna Kellomäki, Robert Luxenhofer, Timo Laaksonen, Nikita Durandin
Published in: Advanced Materials, Issue 37, 2025, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202502386

Detour to success: photoswitching <i>via</i> indirect excitation

Author(s): Kim Kuntze, Jussi Isokuortti, Jacob J. van der Wal, Timo Laaksonen, Stefano Crespi, Nikita A. Durandin, Arri Priimagi
Published in: Chemical Science, Issue 15, 2024, Page(s) 11684-11698, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc02538e

Far-red light-triggered cargo release from liposomes bound to a photosensitizer-cellulose nanofiber hydrogel

Author(s): Olga Lem, Puja Gangurde, Artturi Koivuniemi, Aleksi Keskinen, Alexander Efimov, Nikita Durandin, Timo Laaksonen
Published in: Carbohydrate Polymers, Issue 336, 2024, Page(s) 122134, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2024.122134

Establishing a simple perfusion cell culture system for light-activated liposomes

Author(s): Eija Mäki-Mikola; Patrick Lauren; Natsumi Uema; Kanako Kikuchi; Yuuki Takashima; Timo Laaksonen; Tatu Lajunen
Published in: Scientific Reports, Issue 13, 2023, Page(s) 2050, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-29215-6

Triplet sensitization enables bidirectional isomerization of diazocine with 130 nm redshift in excitation wavelengths

Author(s): Jussi Isokuortti; Thomas Griebenow; Jan-Simon von Glasenapp; Tim Raeker; Mikhail A. Filatov; Timo Laaksonen; Rainer Herges; Nikita A. Durandin
Published in: Chemical Science, Issue 14, 2023, Page(s) 9161-9166, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc02681g

Microfluidic oxygen tolerability screening of nanocarriers for triplet fusion photon upconversion

Author(s): Jussi Isokuortti, Iiro Kiiski, Tiina Sikanen, Nikita Durandin, Timo Laaksonen
Published in: Journal of Materials Chemistry C, Issue 10, 2022, Page(s) 4871-4877, ISSN 2050-7534
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2tc00156j

Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids

Author(s): Puja Gangurde; Mohammad Mahmoudzadeh; Zahra Gounani; Artturi Koivuniemi; Patrick Laurén; Tatu Lajunen; Timo Laaksonen
Published in: Molecular Pharmaceutics, Issue 24, 2023, Page(s) 5728-5738, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00602

Doxorubicin-loaded DNA origami nanostructures: stability in vitreous and their uptake and toxicity in ocular cells

Author(s): Anna Klose, Zahra Gounani, Heini Ijäs, Tatu Lajunen, Veikko Linko, Timo Laaksonen
Published in: Nanoscale, Issue 16, 2024, Page(s) 17585-17598, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4nr01995d

The role of lipid oxidation pathway in reactive oxygen species-mediated cargo release from liposomes

Author(s): Olga Lem, Roosa Kekki, Artturi Koivuniemi, Alexander Efimov, Timo Laaksonen, Nikita Durandin
Published in: Materials Advances, Issue 5, 2024, Page(s) 8878-8888, ISSN 2633-5409
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4ma00535j

Intracellular Dynamics of Extracellular Vesicles by Segmented Trajectory Analysis

Author(s): Kaisa Rautaniemi; Thomas John; Maximilian Richter; Benedikt C. Huck; Jacopo Zini; Brigitta Loretz; Claus-Michael Lehr; Elina Vuorimaa-Laukkanen; Ekaterina Lisitsyna; Timo Laaksonen
Published in: Analytical Chemistry, Issue 94, 2022, Page(s) 17770–17778, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.2c02928

Fluorescence Anisotropy for Detailed Analysis of Doxorubicin Loading into DNA Origami Nanocarriers for Drug Delivery

Author(s): Ekaterina S. Lisitsyna, Anna Klose, Elina Vuorimaa-Laukkanen, Heini Ijäs, Tatu Lajunen, Klaus Suhling, Veikko Linko, Timo Laaksonen
Published in: ACS Applied Nano Materials, Issue 8, 2025, Page(s) 13274-13284, ISSN 2574-0970
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsanm.5c01518

Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery

Author(s): Puja Gangurde, Zahra Gounani, Jacopo Zini, Roberta Teixeira Polez, Monika Österberg, Patrick Lauren, Tatu Lajunen, Timo Laaksonen
Published in: Carbohydrate Polymer Technologies and Applications, Issue 10, 2025, Page(s) 100787, ISSN 2666-8939
Publisher: Elsevier BV
DOI: 10.1016/j.carpta.2025.100787

Thesis and dissertations (3)

Nanocellulose as a delivery platform for pharmaceuticals and nanoparticles

Author(s): Vili-Veli Auvinen
Published in: 2022, ISBN 978-951-51-8507-5
Publisher: Unigrafia Oy

Triplet Energy Transfer in Photon Upconversion and Photoswitching

Author(s): Jussi Isokuortti
Published in: 2022, ISBN 978-952-03-2464-3
Publisher: Punamusta Oy

Entrapment of Photon Upconversion Micelles in Anionic Nanofibrillar Cellulose Hydrogel: Study on System Stability, Upconversion Efficiency and Optimization

Author(s): Emilia Löfman
Published in: 2022
Publisher: Tampere University