Digital Protein Biophysics of Aggregation

Project Information

DiProPhys

Grant agreement ID: 101001615

DOI

10.3030/101001615

EC signature date 11 March 2021

Start date 1 July 2021

End date 30 June 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 715,00

EU contribution

€ 1 999 715,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

Author(s): Tomas Sneideris, Nadia A. Erkamp, Hannes Ausserwöger, Kadi L. Saar, Timothy J. Welsh, Daoyuan Qian, Kai Katsuya-Gaviria, Margaret L. L. Y. Johncock, Georg Krainer, Alexander Borodavka & Tuomas P.J. Knowles
Published in: Nat Commun, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42374-4

Design of amyloidogenic peptide traps

Author(s): Danny D. Sahtoe, Ewa A. Andrzejewska, Hannah L. Han, Enrico Rennella, Matthias M. Schneider, Georg Meisl, Maggie Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K. Bera, Lewis E. Kay, Tuomas P. J. Knowles & David Baker
Published in: Nature Chemical Biology, 2024, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-024-01578-5

Enhanced surface nanoanalytics of transient biomolecular processes

Author(s): Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli Hakala, Roman Schmid, Yaduo Feng Tadas Kartanas, Ayaka Kamada, Michele Vendruscolo, Francesco Simone Ruggeri, Tuomas P J Knowles
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abq3151

Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration

Author(s): Sebastian Fiedler, Sean R. A. Devenish, Alexey S. Morgunov, Alison Ilsley, Francesco Ricci, Marc Emmenegger, Vasilis Kosmoliaptsis, Elitza S. Theel, John R. Mills, Anton M. Sholukh, Adriano Aguzzi, Akiko Iwasaki, Andrew K. Lynn & Tuomas P. J. Knowles
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-22214-z

Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2

Author(s): Viola Denninger, Catherine K. Xu, Georg Meisl, Alexey S. Morgunov, Sebastian Fiedler, Alison Ilsley, Marc Emmenegger, Anisa Y. Malik, Monika A. Piziorska, Matthias M. Schneider, Sean R. A. Devenish, Vasilis Kosmoliaptsis, Adriano Aguzzi, Heike Fiegler, and Tuomas P. J. Knowles
Published in: ACS Infect. Dis, 2022, ISSN 2373-8227
Publisher: ACS
DOI: 10.1021/acsinfecdis.1c00486

Formation of Protein Nanoparticles in Microdroplet Flow Reactors

Author(s): Qi Zhang; Zenon Toprakcioglu; Akhila K. Jayaram; Guangsheng Guo; Xiayan Wang; Tuomas P. J. Knowles
Published in: ACS Nano, 2023, ISSN 2470-1343
Publisher: ACS
DOI: 10.1021/acsnano.3c00107

Non-peer reviewed articles (2)

The Alzheimer's Amyloid beta peptide forms biomolecular condensates that trigger amyloid aggregation

Author(s): Greta Sneideriene, Alicia Gonzalez Diaz, Sourav Das Adhikari, Jiapeng Wei, Thomas Michaels, Tomas Sneideris, Sara Linse, Michele Vendruscolo, Kanchan Garai, Tuomas Knowles
Published in: BioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.01.14.575549

α-Synuclein oligomers form by secondary nucleation

Author(s): Catherine K Xu, Georg Meisl, Ewa Andrzejewska, Georg Krainer, Alexander J Dear, Marta Castellana Cruz, Soma Turi, Raphael Jacquat, William E Arter, Michele Vendruscolo, Sara Linse, Tuomas PJ Knowles
Published in: BioXriv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboraory
DOI: 10.1101/2023.05.28.542651