Towards the discovery of cellular RNA-binding proteins with master regulatory roles in virus infection

Project Information

vRNP-capture

Grant agreement ID: 101001634

DOI

10.3030/101001634

EC signature date 11 March 2021

Start date 1 December 2021

End date 30 November 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 916,00

EU contribution

€ 1 999 916,00

Coordinated by

UNIVERSITY OF GLASGOW
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (7)

The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity

Author(s): Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge, Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52918-x

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

Author(s): Wael Kamel, Vincenzo Ruscica, Azman Embarc-Buh, Zaydah R. de Laurent, Manuel Garcia-Moreno, Yana Demyanenko, Richard J. Orton, Marko Noerenberg, Meghana Madhusudhan, Louisa Iselin, Aino I. Järvelin, Maximilian Hannan, Eduardo Kitano, Samantha Moore, Andres Merits, Ilan Davis, Shabaz Mohammed, Alfredo Castello
Published in: Molecular Cell, Issue 84, 2024, Page(s) 4896-4911.e7, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.11.015

Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis

Author(s): Neus Mestre-Farràs; Santiago Guerrero; Nadine Bley; Ezequiel Rivero; Olga Coll; Eva Borràs; Eduard Sabidó; Alberto Indacochea; Carlos Casillas-Serra; Aino I Järvelin; Baldomero Oliva; Alfredo Castello; Stefan Hüttelmaier; Fátima Gebauer
Published in: Nuc Acid Res, Issue Journal, 2022, ISSN 1362-4962
Publisher: Nucleic Acids Res
DOI: 10.1093/nar/gkac605

Exploring the expanding universe of host-virus interactions mediated by viral RNA

Author(s): Alfredo Castello, Lucía Álvarez, Wael Kamel, Louisa Iselin, Janosch Hennig
Published in: Molecular Cell, Issue 84, 2024, Page(s) 3706-3721, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.08.027

Uncovering viral RNA-host cell interactions on a proteome-wide scale

Author(s): Louisa Iselin, Natasha Palmalux, Wael Kamel, Peter Simmonds, Shabaz Mohammed, Alfredo Castello
Published in: Trends Biochem Sci, Issue Journal, 2022, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2021.08.002

Repurposed 3D Printer Allows Economical and Programmable Fraction Collection for Proteomics of Nanogram Scale Samples

Author(s): Eduardo S. Kitano, Gareth Nisbet, Yana Demyanenko, Katarzyna M Kowalczyk, Louisa Iselin, Stephen Cross, Alfredo Castello, and Shabaz Mohammed
Published in: Anal Chem, Issue Journal, 2024, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.4c01731

Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome

Author(s): Haiqi Xu, Linzhen Kong, Jingfei Cheng, Khatoun Al Moussawi, Xiufei Chen, Aleema Iqbal, Peter A. C. Wing, James M. Harris, Senko Tsukuda, Azman Embarc-Buh, Guifeng Wei, Alfredo Castello, Skirmantas Kriaucionis, Jane A. McKeating, Xin Lu, Chun-Xiao Song
Published in: Nature Methods, Issue 21, 2024, Page(s) 2024-2033, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-024-02439-8

Other (5)

Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

Author(s): Alexandra Wilson, Wael Kamel, Kelsey Davies, Zaydah R. De Laurent, Rozeena Arif, Lesley Bell-Sakyi, Douglas Lamont, Yana Demyanenko, Marko Noerenberg, Alain Kohl, Shabaz Mohammed, Alfredo Castello, Benjamin Brennan
Published in: BioRxiv, Issue Preprint, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.06.611624

Compositional analysis of Sindbis virus ribonucleoproteins reveals an extensive co-opting of key nuclear RNA-binding proteins

Author(s): Wael Kamel, Vincenzo Ruscica, Manuel Garcia Moreno, Natasha Palmalux, Louisa Iselin, Maximilian Hannan, Aino Jarvelin, Marko Noerenberg, Samantha Moore, Andres Merits, Ilan Davis, Javier Martinez, Shabaz Mohammed, Alfredo Castello
Published in: BioRxiv, Issue Preprint, 2023
Publisher: BioRxiv
DOI: 10.1101/2021.10.06.463336

XRN1 supplies free nucleotides to feed alphavirus replication

Author(s): Vincenzo Ruscica, Louisa Iselin, Ryan Hull, Azman Embarc-Buh, Samyukta Narayanan, Natasha Palmalux, Namah Raut, Quan Gu, Honglin Chen, Marko Noerenberg, Zaydah R. de Laurent, Josmi Joseph, Michelle Noble, Catia Igreja, David L. Robertson, Joseph Hughes, Shabaz Mohammed, Vicent Pelechano, Ilan Davis, Alfredo Castello
Published in: BioRxiv, Issue Preprint, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.12.09.625895

Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection

Author(s): Manuel Garcia-Moreno, Robin Truman, Honglin Chen, Louisa Iselin, Caroline E. Lenz, Jeffrey Y. Lee, Kate Dicker, Marko Noerenberg, Thibault J.M. Sohier, Natasha Palmalux, Aino I. Järvelin, Wael Kamel, Vincenzo Ruscica, Emiliano P. Ricci, Ilan Davis, Shabaz Mohammed and Alfredo Castello
Published in: BioRxiv, Issue Preprint, 2023
Publisher: BioRxiv
DOI: 10.1101/2023.06.14.544764

The molecular dissection of TRIM25‘s RNA-binding mechanism provides key insights into its antiviral activity

Author(s): Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge. Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig
Published in: Research Square, Issue Preprint, 2023
Publisher: Research Scuare
DOI: 10.21203/rs.3.rs-3692619/v1