Light-induced synthesis of protein-drug conjugates for imaging and therapy

Project Information

PhotoPHARMA

Grant agreement ID: 101001734

DOI

10.3030/101001734

EC signature date 20 January 2021

Start date 1 February 2022

End date 31 January 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

New tactics in the design of theranostic radiotracers

Author(s): Cesare Berton, Simon Klingler, Stanislav Prytuliak, Jason P. Holland
Published in: npj Imaging, Issue 2, 2024, Page(s) 1-15, ISSN 2948-197X
Publisher: Springler Nature
DOI: 10.1038/s44303-024-00027-1

A rotaxane-based platform for tailoring the pharmacokinetics of cancer-targeted radiotracers

Author(s): d'Orchymont, Faustine; Holland, Jason P.
Published in: Chemical Science, 2022, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc03928a

Charting the Chemical and Mechanistic Scope of Light-Triggered Protein Ligation

Author(s): Daniel F. Earley, Amaury Guillou, Simon Klingler, Rachael Fay, Melanie Gut, Faustine d’Orchymont, Shamisa Behmaneshfar, Linus Reichert, Jason P. Holland
Published in: JACS Au, Issue 2, 2023, Page(s) 646-664, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.1c00530

Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging

Author(s): Rachael Fay, Jason P. Holland
Published in: Chemistry – A European Journal, Issue 27, 2023, Page(s) 4893-4897, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202100061

Photoactivatable Fluorescent Tags for Dual-Modality Positron Emission Tomography Optical Imaging

Author(s): Amaury Guillou, Eda Nisli, Simon Klingler, Anthony Linden, Jason P. Holland
Published in: Journal of Medicinal Chemistry, Issue 65, 2023, Page(s) 811-823, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c01899

The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a ⁸⁹Zr-Radiolabeled Antibody

Author(s): Amaury Guillou, Daniel F. Earley, Simon Klingler, Eda Nisli, Laura J. Nüesch, Rachael Fay, Jason P. Holland
Published in: Bioconjugate Chemistry, Issue 32, 2023, Page(s) 1263-1275, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00172

Automated light-induced synthesis of 89Zr-radiolabeled antibodies for immuno-positron emission tomography.

Author(s): Klingler, Simon; Holland, Jason P.
Published in: Sci. Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-04626-5

Cooperative Capture Synthesis of Functionalized Heterorotaxanes─Chemical Scope, Kinetics, and Mechanistic Studies

Author(s): d'Orchymont, Faustine; Holland, Jason P.
Published in: J. Am. Chem. Soc., 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c04111

Heptadentate chelates for ⁸⁹Zr-radiolabelling of monoclonal antibodies

Author(s): Amaury Guillou, Ali Ouadi, Jason P. Holland
Published in: Inorganic Chemistry Frontiers, Issue 9, 2024, Page(s) 3071-3081, ISSN 2052-1553
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2qi00442a

HNODThia: A Promising Chelator for the Development of ⁶⁴Cu Radiopharmaceuticals

Author(s): Ina Hierlmeier, Amaury Guillou, Daniel F. Earley, Anthony Linden, Jason P. Holland, Mark D. Bartholomä
Published in: Inorganic Chemistry, Issue 62, 2023, Page(s) 20677-20687, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.3c01616

Photoactivatable bis(thiosemicarbazone) derivatives for copper-64 radiotracer synthesis

Author(s): Daniel F. Earley, Jose Esteban Flores, Amaury Guillou, Jason P. Holland
Published in: Dalton Transactions, Issue 51, 2024, Page(s) 5041-5052, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2dt00209d

Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry

Author(s): Daniel F. Earley, Amaury Guillou, Dion van der Born, Alex J. Poot, Jason P. Holland
Published in: Molecules, Issue 26, 2024, Page(s) 764, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26030764

A rotaxane-based platform for tailoring the pharmacokinetics of cancer-targeted radiotracers

Author(s): d'Orchymont, Faustine; Holland, Jason P
Published in: Commun. Chem, Issue 1, 2023, ISSN 2399-3669
Publisher: Spinger Nature
DOI: 10.1038/s42004-023-00906-5

Radiolabelled ¹⁷⁷Lu‐Bispidine‐Trastuzumab for Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancers

Author(s): Patrick A. Cieslik, Simon Klingler, Mirja Nolff, Jason P. Holland
Published in: Chemistry – A European Journal, Issue 30, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303805