Human mini hearts: looking for culprits and victims in cardiac disease

Project Information

Mini-HEART

Grant agreement ID: 101001746

DOI

10.3030/101001746

EC signature date 23 July 2021

Start date 1 September 2021

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Software Tool for Automatic Quantification of Sarcomere Length and Organization in Fixed and Live 2D and 3D Muscle Cell Cultures In Vitro

Author(s): Stein JM, Arslan U, Franken M, de Greef JC, E Harding S, Mohammadi N, Orlova VV, Bellin M, Mummery CL, van Meer BJ.
Published in: Current Protocols, 2022, ISSN 2691-1299
Publisher: Wiley
DOI: 10.1002/cpz1.462

Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Author(s): Nguyen PD, Gooijers I, Campostrini G, Verkerk AO, Honkoop H, Bouwman M, de Bakker DEM, Koopmans T, Vink A, Lamers GEM, Shakked A, Mars J, Mulder AA, Chocron S, Bartscherer K, Tzahor E, Mummery CL, de Boer TP, Bellin M, Bakkers J
Published in: Science, Issue VOL 380 (6646), 2023, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abo6718

Patient-specific primary and pluripotent stem cell-derived stromal cells recapitulate key aspects of arrhythmogenic cardiomyopathy

Author(s): Maione AS, Meraviglia V, Iengo L, Rabino M, Chiesa M, Catto V, Tondo C, Pompilio G, Bellin M, Sommariva E
Published in: Scientific Reports, Issue 13, 16179 (2023), 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-43308-2

Heart and kidney organoids maintain organ-specific function in a microfluidic system.

Author(s): Gabbin B, Meraviglia V, Angenent ML, Ward-van Oostwaard D, Sol W, Mummery CL, Rabelink TJ, van Meer BJ, van den Berg CW, Bellin M
Published in: Mater Today Bio, Issue VOL 23 (2023), 2023, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2023.100818

Maturingdifferentiated human pluripotent stem cells in vitro: methods and challenges

Author(s): Ottaviani D, Ter Huurne M, Elliott DA, Bellin M, Mummery CL
Published in: Development, 2023, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.201103

Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy

Author(s): Subramaniam G, Schleicher K, Kovanich D, Zerio A, Folkmanaite M, Chao YC, Surdo NC, Koschinski A, Hu J, Scholten A, Heck AJR, Ercu M, Sholokh A, Park KC, Klussmann E, Meraviglia V, Bellin M, Zanivan S, Hester S, Mohammed S, Zaccolo M
Published in: Circulation Research, Issue 132, 2023, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.321448

RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome

Author(s): Sambri I, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo MEG, Dokládal L, Vilardo C, Monfregola J, Zampelli N, Vecchio Blanco FD, Torella A, Ruosi C, Fecarotta S, Parenti G, Staiano L, Bellin M, Huber LA, De Virgilio C, Trepiccione F, Nigro V, Ballabio A
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38428-2

Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy

Author(s): Tsui H, van Kampen SJ, Han SJ, Meraviglia V, van Ham WB, Casini S, van der Kraak P, Vink A, Yin X, Mayr M, Bossu A, Marchal GA, Monshouwer-Kloots J, Eding J, Versteeg D, de Ruiter H, Bezstarosti K, Groeneweg J, Klaasen SJ, van Laake LW, Demmers JAA, Kops GJPL, Mummery CL, van Veen TAB, Remme CA, Bellin M, van Rooij E.
Published in: Science Translational Medicine, Issue VOL 15 (668), 2023, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.add4248

Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain

Author(s): Doni D, Cavion F, Bortolus M, Baschiera E, Muccioli S, Tombesi G, d'Ettorre F, Ottaviani D, Marchesan E, Leanza L, Greggio E, Ziviani E, Russo A, Bellin M, Sartori G, Carbonera D, Salviati L, Costantini P.
Published in: Cell Death Dis, Issue 805 (2023), 2023, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-023-06320-y

Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia

Author(s): Campostrini G, Kosmidis G, Ward-van Oostwaard D, Davis RP, Yiangou L, Ottaviani D, Veerman CC, Mei H, Orlova VV, Wilde AAM, Bezzina CR, Verkerk AO, Mummery CL, Bellin M.
Published in: Cardiovascular Research, Issue 119 (1), 2023, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac059

Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?

Author(s): Viviana Meraviglia; Mireia Alcalde; Mireia Alcalde; Oscar Campuzano; Oscar Campuzano; Oscar Campuzano; Milena Bellin; Milena Bellin; Milena Bellin
Published in: Articles publicats (D-CM), Issue 1, 2021, ISSN 2297-055X
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2021.784715

Toward Human Models of Cardiorenal Syndrome in vitro

Author(s): Beatrice Gabbin; Viviana Meraviglia; Christine L. Mummery; Christine L. Mummery; Ton J. Rabelink; Ton J. Rabelink; Berend J. van Meer; Cathelijne W. van den Berg; Cathelijne W. van den Berg; Milena Bellin; Milena Bellin; Milena Bellin
Published in: Frontiers in Cardiovascular Medicine, Issue 2, 2022, ISSN 2297-055X
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.889553

Non-peer reviewed articles (1)

From mechanisms of heart failure to clinical heart success

Author(s): Jeroen Bakkers; Milena Bellin; Julija Hmeljak; Ravi Karra
Published in: Disease Models & Mechanisms, Vol 16, Iss 5 (2023), Issue 3, 2023, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.050282