On the chemical origins of biological metabolism

Project Information

MetabolismOrigins

Grant agreement ID: 101001752

DOI

10.3030/101001752

EC signature date 4 November 2021

Start date 1 December 2021

End date 30 November 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 153 020,00

EU contribution

€ 2 153 020,00

Coordinated by

CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis.

Author(s): Sophia A. Rauscher; Joseph Moran
Published in: Angewandte Chemie International Edition, Issue 2022, 2022, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202212932

A prebiotic Krebs cycle analog generates amino acids with H2 and NH3 over nickel

Author(s): Harpreet Kaur, Sophia A. Rauscher, Emilie Werner, Youngdong Song, Jing Yi, Wahnyalo Kazöne, William F. Martin, Harun Tüysüz , Joseph Moran
Published in: Chem, Issue 2024, 2024, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2024.02.001

Metal-Pyridoxal Cooperativity in Nonenzymatic Transamination

Author(s): Quentin Dherbassy, Robert J. Mayer, Kamila B. Muchowska, and Joseph Moran
Published in: Journal of the American Chemical Society, Issue 2023, 2023, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c03542

Pinpointing Conditions for a Metabolic Origin of Life: Underlying Mechanisms and the Role of Coenzymes

Author(s): Joris Zimmermann, Emilie Werner, Shunjiro Sodei, Joseph Moran
Published in: Accounts of Chemical Research, Issue 57, 2024, Page(s) 3032-3043, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.4c00423

A single phosphorylation mechanism in early metabolism – the case of phosphoenolpyruvate

Author(s): Joris Zimmermann; Robert J. Mayer; Joseph Moran
Published in: Chemical Science, Issue 2023, 2023, Page(s) 14100-14108, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc04116f

A Nonenzymatic Analog of Pyrimidine Nucleobase Biosynthesis.

Author(s): Jing Yi; Harpreet Kaur; Wahnyalo Kazöne; Sophia A. Rauscher; Louis‐Albin Gravillier; Kamila B. Muchowska; Joseph Moran
Published in: Angewandte Chemie International Edition, Issue 2022, 2022, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/ange.202117211

Coenzymes in a pre-enzymatic metabolism

Author(s): Quentin Dherbassy, Robert J. Mayer, Joseph Moran
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.adr5357

Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis

Author(s): Robert J. Mayer, Joseph Moran
Published in: Angewandte Chemie International Edition, Issue 2022, 2022, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202212237

Metal ions turn on a stereoselective nonenzymatic reduction of keto acids by the coenzyme NADH

Author(s): Robert J. Mayer, Joseph Moran
Published in: Chem, Issue 2024, 2024, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2024.05.007

Mechanistic Insight into Metal Ion-Catalyzed Transamination.

Author(s): Robert J. Mayer; Harpreet Kaur; Sophia A. Rauscher; Joseph Moran
Published in: Journal of the American Chemical Society, Issue 2021, 2021, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c08535

Quantification of the hydride donor abilities of NADH, NADPH, and BH 3 CN − in water

Author(s): Joseph Moran; Robert Mayer
Published in: Organic & Biomolecular Chemistry, Issue 2023, 2022, ISSN 1477-0539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ob02041f

Conversion of pyridoxal to pyridoxamine with <scp>NH</scp>₃ and <scp>H</scp>₂ on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions

Author(s): Manon Laura Schlikker, Max Brabender, Loraine Schwander, Carolina Garcia Garcia, Maximillian Burmeister, Sabine Metzger, Joseph Moran, William F. Martin
Published in: The FEBS Journal, 2024, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.17357

Metal/ADP Complexes Promote Phosphorylation of Ribonucleotides

Author(s): Emilie Werner; Silvana Pinna; Robert J. Mayer; Joseph Moran
Published in: Journal of the American Chemical Society, Issue 1, 2023, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c08047

Nonenzymatic Hydration of Phosphoenolpyruvate: General Conditions for Hydration in Protometabolism by Searching Across Pathways

Author(s): Joris Zimmermann, Atalay Bora Basar, Joseph Moran
Published in: Angewandte Chemie International Edition, Issue 64, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202410698

Book chapters (1)

Mechanism and catalysis of nonenzymatic analogs of amino acid biosynthesis

Author(s): Robert J. Mayer; Joseph Moran
Published in: Advances in Physical Organic Chemistry ISBN: 9780443193408, Issue 1, 2023
Publisher: Elsevier
DOI: 10.1016/bs.apoc.2023.07.001