Loss of chromosome Y in immune cells: targeting disease mechanisms and tools for clinical applications

Project Information

HEARTLY

Grant agreement ID: 101001789

DOI 10.3030/101001789

EC signature date 26 May 2021

Start date 1 June 2021

End date 31 May 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 982,00

EU contribution € 1 999 982,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

Author(s): Moeen Riaz, Jonas Mattisson, Galina Polekhina, Andrew Bakshi, Jonatan Halvardson, Marcus Danielsson, Adam Ameur, John McNeil, Lars A. Forsberg, Paul Lacaze
Published in: Cell & Bioscience, Issue 11(205), 2021, ISSN 2045-3701
Publisher: Society of Chinese Bioscientists in America
DOI: 10.1186/s13578-021-00716-z

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

Author(s): Sano, S., Horitani, K., Ogawa, H., Halvardson, J., Chavkin, N. W., Wang, Y., Sano, M., Mattisson, J., Hata, A., Danielsson, M., Miura-Yura, E., Zaghlool, A., Evans, M., A., Fall, T., De Hoyos, H., N., Sundstrom, J., Yura, Y., Kour, A., Arai, Y., Thel, M., C., Arai, Y., Mychaleckyj, J., C., Hirschi, K., K., Forsberg, L., A. and Walsh, K.
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abn3100

Loss of chromosome Y in regulatory T cells

Author(s): Jonas Mattisson; Jonatan Halvardson; Hanna Davies; Bożena Bruhn-Olszewska; Paweł Olszewski; Marcus Danielsson; Josefin Bjurling; Amanda Lindberg; Ammar Zaghlool; Edyta Rychlicka-Buniowska; Jan P. Dumanski; Lars A. Forsberg
Published in: BMC Genomics, Vol 25, Iss 1, Pp 1-11 (2024), Issue 1, 2024, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-024-10168-7

Reply to Guo’s commentary on: “Immune cells lacking Y chromosome show dysregulation of autosomal gene expression”

Author(s): Lars Forsberg
Published in: Cellular and Molecular Life Sciences, 2022, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-021-04028-w

Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99

Author(s): Jonas Mattisson, Marcus Danielsson, Maria Hammond, Hanna Davies, Caroline J. Gallant, Jessica Nordlund, Amanda Raine, Malin Edén, Lena Kilander, Martin Ingelsson, Jan P. Dumanski, Jonatan Halvardson, Lars A. Forsberg
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-94588-5

Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?

Author(s): Viktor Ljungström, Jonas Mattisson, Jonatan Halvardson, Tatjana Pandzic, Hanna Davies, Edyta Rychlicka-Buniowska, Marcus Danielsson, Paul Lacaze, Lucia Cavelier, Jan P. Dumanski, Panagiotis Baliakas, Lars A. Forsberg
Published in: Leukemia, 2021, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-021-01456-2