We have pioneered soft-clamped mechanical resonators at the low temperatures (T<50 mK) inside a dilution refrigerator. We could probe them both using optical [Page et al., Communications Physics 2021] and microwave [Seis et al., Nature Communications 2022] radiation. We could confirm that the quality factor improves with lower temperatures tovalues above 10^9 even for metallized membranes. We have also implemented optomechanical systems at mK-temperatures, with a high-Finesse optical cavity that accommodates a soft-clamped membrane. Furthermore, we have experimentally investigated parametric driving of soft-clamped membrane resonators. In collaboration with ETH Zurich, we could demonstrate strong parametric coupling between different membrane modes [Hälg et al., Physical Review Letters 2022]. In our own work, we have observed unexpected parametric resonances, whose origin we are currently exploring. Independently, we have implemented strong thermomechanical noise squeezing through the parametric drive, stabilized by feedback. Finally, we have set up a room-temperature experimental platform in which a single spin system – hosted by a nitrogen vacancy defect in diamond – can be scanned over a sample. Optically detecting the NV’s electron spin resonance then allows us mapping magnetic fields and gradients. We are currently applying this setup to cobalt nanomagnets.