Exploitation of enzyme promiscuity to generate ribosomal natural product diversity

Project Information

EXPLORE

Grant agreement ID: 101002326

DOI 10.3030/101002326

EC signature date 16 February 2021

Start date 1 June 2021

End date 31 May 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 977 125,00

EU contribution € 1 977 125,00

Coordinated by

GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Germany

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (6)

Robotic synthesis of peptides containing metal-oxide-based amino acids

Author(s): She, Shan; Bell, Nicola L.; Zheng, Dazhong; Mathieson, Jennifer S.; Castro, Maria D.; Long, De-Liang; Koehnke, Jesko; Cronin, Leroy
Published in: Chem, 2022, ISSN 2451-9308
Publisher: Cell Press
DOI: 10.1016/j.chempr.2022.07.007

Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis

Author(s): Sebastian Adam, Dazhong Zheng, Andreas Klein, Carsten Volz, William Mullen, Sally L. Shirran, Brian O. Smith, Olga V. Kalinina, Rolf Müller & Jesko Koehnke
Published in: Nature Chemistry, 2023, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-023-01153-w

PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery

Author(s): Jean-Baptiste Masclef, Emmanuelle M. N. Acs, Jesko Koehnke, Joëlle Prunet, and Bernhard V. K. J. Schmidt
Published in: Macromolecules, 2024, ISSN 0024-9297
Publisher: American Chemical Society
DOI: 10.1021/acs.macromol.4c00528

Supramolecular Click Chemistry for Surface Modification of Quantum Dots Mediated by Cucurbit[7]uril

Author(s): Katie McGuire; Suhang He; Jennifer Gracie; Charlotte Bryson; Dazhong Zheng; Alasdair W. Clark; Jesko Koehnke; David J. France; Werner M. Nau; Tung-Chun Lee; William J. Peveler
Published in: ACS Nano, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c06601

Trapping of a Polyketide Synthase Module after C−C Bond Formation Reveals Transient Acyl Carrier Domain Interactions

Author(s): Maria Dell, Mai Anh Tran, Michael J. Capper, Srividhya Sundaram, Jonas Fiedler, Jesko Koehnke, Ute A. Hellmich, Christian Hertweck
Published in: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202315850

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Author(s): Sebastian Adam; Franziska Fries; Alexander von Tesmar; Sari Rasheed; Selina Deckarm; Carla F. Sousa; Roman Reberšek; Timo Risch; Stefano Mancini; Jennifer Herrmann; Jesko Koehnke; Olga V. Kalinina; Rolf Müller
Published in: Journal of the American Chemical Society, 2024, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c13208