Exploitation of enzyme promiscuity to generate ribosomal natural product diversity

Project Information

EXPLORE

Grant agreement ID: 101002326

DOI

10.3030/101002326

EC signature date 16 February 2021

Start date 1 June 2021

End date 31 May 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 977 125,00

EU contribution

€ 1 977 125,00

Coordinated by

GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (8)

Robotic synthesis of peptides containing metal-oxide-based amino acids

Author(s): She, Shan; Bell, Nicola L.; Zheng, Dazhong; Mathieson, Jennifer S.; Castro, Maria D.; Long, De-Liang; Koehnke, Jesko; Cronin, Leroy
Published in: Chem, 2022, ISSN 2451-9308
Publisher: Cell Press
DOI: 10.1016/j.chempr.2022.07.007

Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis

Author(s): Sebastian Adam, Dazhong Zheng, Andreas Klein, Carsten Volz, William Mullen, Sally L. Shirran, Brian O. Smith, Olga V. Kalinina, Rolf Müller & Jesko Koehnke
Published in: Nature Chemistry, 2023, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-023-01153-w

PEGose Block Poly(lactic acid) Nanoparticles for Cargo Delivery

Author(s): Jean-Baptiste Masclef, Emmanuelle M. N. Acs, Jesko Koehnke, Joëlle Prunet, and Bernhard V. K. J. Schmidt
Published in: Macromolecules, 2024, ISSN 0024-9297
Publisher: American Chemical Society
DOI: 10.1021/acs.macromol.4c00528

Supramolecular Click Chemistry for Surface Modification of Quantum Dots Mediated by Cucurbit[7]uril

Author(s): Katie McGuire; Suhang He; Jennifer Gracie; Charlotte Bryson; Dazhong Zheng; Alasdair W. Clark; Jesko Koehnke; David J. France; Werner M. Nau; Tung-Chun Lee; William J. Peveler
Published in: ACS Nano, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c06601

Trapping of a Polyketide Synthase Module after C−C Bond Formation Reveals Transient Acyl Carrier Domain Interactions

Author(s): Maria Dell, Mai Anh Tran, Michael J. Capper, Srividhya Sundaram, Jonas Fiedler, Jesko Koehnke, Ute A. Hellmich, Christian Hertweck
Published in: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202315850

Probing the Origin of Affinity in the GM1-Cholera Toxin Complex through Site-Selective Editing with Fluorine

Author(s): Christina Jordan, Taiki Hayashi, Arnelle Löbbert, Jingran Fan, Charlotte S. Teschers, Kathrin Siebold, Marialuisa Aufiero, Felix Pape, Emma Campbell, Alexander Axer, Kathrin Bussmann, Klaus Bergander, Jesko Köhnke, Alvar D. Gossert, Ryan Gilmour
Published in: ACS Central Science, Issue 10, 2024, Page(s) 1481-1489, ISSN 2374-7943
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acscentsci.4c00622

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Author(s): Sebastian Adam; Franziska Fries; Alexander von Tesmar; Sari Rasheed; Selina Deckarm; Carla F. Sousa; Roman Reberšek; Timo Risch; Stefano Mancini; Jennifer Herrmann; Jesko Koehnke; Olga V. Kalinina; Rolf Müller
Published in: Journal of the American Chemical Society, 2024, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c13208

A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor

Author(s): Mariia Zmyslia, Michael J. Capper, Michael Grimmeisen, Kerstin Sartory, Benedikt Deuringer, Mohamed Abdelsalam, Kaiwei Shen, Manfred Jung, Wolfgang Sippl, Hans-Georg Koch, Laurine Kaul, Regine Süss, Jesko Köhnke, Claudia Jessen-Trefzer
Published in: RSC Chemical Biology, Issue 6, 2025, Page(s) 21-35, ISSN 2633-0679
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4cb00127c