Dissecting and targeting senescence programs to advance Hematopoietic Stem Cell-based gene therapies

Project Information

ReviveSTEM

Grant agreement ID: 101003186

DOI

10.3030/101003186

EC signature date 24 July 2021

Start date 1 March 2022

End date 28 February 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

OSPEDALE SAN RAFFAELE SRL
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (3)

Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells

Author(s): Samuele Ferrari, Aurelien Jacob, Daniela Cesana, Marianne Laugel, Stefano Beretta, Angelica Varesi, Giulia Unali, Anastasia Conti, Daniele Canarutto, Luisa Albano, Andrea Calabria, Valentina Vavassori, Carlo Cipriani, Maria Carmina Castiello, Simona Esposito, Chiara Brombin, Federica Cugnata, Oumeya Adjali, Eduard Ayuso, Ivan Merelli, Anna Villa, Raffaella Di Micco, Anna Kajaste-Rudnitski, Eugenio
Published in: Cell Stem Cell, Issue 29, 2022, Page(s) 1428-1444.e9, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2022.09.001

Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy

Author(s): Samuele Ferrari, Erika Valeri, Anastasia Conti, Serena Scala, Annamaria Aprile, Raffaella Di Micco, Anna Kajaste-Rudnitski, Eugenio Montini, Giuliana Ferrari, Alessandro Aiuti, Luigi Naldini
Published in: Cell Stem Cell, Issue 30, 2024, Page(s) 549-570, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2023.04.014

Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs

Author(s): Stefania Crippa, Anastasia Conti, Valentina Vavassori, Samuele Ferrari, Stefano Beretta, Silvia Rivis, Roberto Bosotti, Serena Scala, Stefania Pirroni, Raisa Jofra-Hernandez, Ludovica Santi, Luca Basso-Ricci, Ivan Merelli, Pietro Genovese, Alessandro Aiuti, Luigi Naldini, Raffaella Di Micco, Maria Ester Bernardo
Published in: Molecular Therapy, Issue 31, 2023, Page(s) 230-248, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.08.011