Parkinson's disease: does it all start with gut inflammation?

Project Information

PD-GUT

Grant agreement ID: 101003329

DOI

10.3030/101003329

EC signature date 2 April 2021

Start date 1 December 2021

End date 31 May 2028

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 722,50

EU contribution

€ 1 999 722,50

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Emerging strategies, applications and challenges of targeting NAD+ in the clinic

Author(s): Jianying Zhang, He-Ling Wang, Sofie Lautrup, Hilde Loge Nilsen, Jonas T. Treebak, Leiv Otto Watne, Geir Selbæk, Lindsay E. Wu, Torbjørn Omland, Eija Pirinen, Tin Cho Cheung, Jun Wang, Mathias Ziegler, Ole-Bjørn Tysnes, Rubén Zapata-Pérez, Santina Bruzzone, Carles Canto, Michela Deleidi, Georges E. Janssens, Riekelt H. Houtkooper, Morten Scheibye-Knudsen, Masaya Koshizaka, Koutaro Yokote, Eric
Published in: Nature Aging, Issue 5, 2025, Page(s) 1704-1731, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43587-025-00947-6

<i>C9orf72</i> Repeat Expansion Induces Metabolic Dysfunction in Human <scp>iPSC</scp> ‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Author(s): Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi
Published in: Glia, Issue 74, 2025, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.70080

Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models

Author(s): Electra Brunialti, Alessandro Villa, Eva M. Szego, Pietro La Vitola, Denise Drago, Radmila Pavlovic, Laura Fontana, Doga Tuna, Alessia Panzeri, Clara Meda, Christin Weissleder, Ornella Rondinone, Mattia Pitasi, Monica Miozzo, Michela Deleidi, Annapaola Andolfo, Donato A. Di Monte, Paolo Ciana
Published in: Journal of Neuroinflammation, Issue 22, 2025, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-025-03616-y

Reassessing neurodegenerative disease: immune protection pathways and antagonistic pleiotropy

Author(s): Francesca Provenzano, Michela Deleidi
Published in: Trends in Neurosciences, Issue 44, 2025, Page(s) 771-780, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2021.06.006

Glycolipids in Parkinson's disease: beyond neuronal function

Author(s): Fokion Spanos, Michela Deleidi
Published in: FEBS Open Bio, Issue 13, 2023, Page(s) 1558-1579, ISSN 2211-5463
Publisher: Elsevier BV
DOI: 10.1002/2211-5463.13651

A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma

Author(s): Mattia Ballerini, Serena Galiè, Punit Tyagi, Carlotta Catozzi, Hariam Raji, Amir Nabinejad, Angeli D. G. Macandog, Alessandro Cordiale, Bianca Ionela Slivinschi, Karol K. Kugiejko, Martina Freisa, Paola Occhetta, Jennifer A. Wargo, Pier F. Ferrucci, Emilia Cocorocchio, Nicola Segata, Andrea Vignati, Andrey Morgun, Michela Deleidi, Teresa Manzo, Marco Rasponi, Luigi Nezi
Published in: Nature Biomedical Engineering, Issue 9, 2025, Page(s) 967-984, ISSN 2157-846X
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41551-024-01318-z

Other (1)

Glycolipids in Parkinson's disease: beyond neuronal function.

Author(s): Fokion Spanos and Michela Deleidi
Published in: 2023
Publisher: FEBS Press