Project description
An in vitro 3D model of glioma
Gliomas are the most common primary brain tumours and emerge from the supporting tissue of the brain. However, the lack of appropriate disease models has hampered the testing of new drug candidates. Using a bottom-up engineering approach and microfluidics, the EU-funded GliomaChip project proposes to develop 3D micro-patterned cellular constructs that can be exploited to study various aspects of glioma biology, including migration and angiogenesis. The long-term plan is to construct an in vitro 3D glioma-on-a-chip model mimicking the complex in vivo microenvironment of glioma that can be used to test new drugs and improve the management of patients.
Objective
28% of all primary brain tumors and central nervous system tumors and 80% of malignant tumors are gliomas, which arise from the supportive tissues in the brain. Yet, our ability to effectively treat these cancers is limited by our knowledge of the disease and our ability to test new treatments on accurate models. Advances in microfluidics and cell encapsulation within hydrogels have made significant strides in trying to meet these needs, but the potential to use these technologies for engineering physiologically relevant tissue models has yet to be fully realized. Here, we propose to investigate cancer biology using a microfluidic device with three-dimensional (3D) micro-patterned cellular constructs that may be subjected to flow through microfluidic channels. Using the developed model, we aim to understand the cellular gliomagenesis, glioma cell migration, and angiogenesis and further test drug susceptibility to demonstrate the relevance of the proposed model. To achieve these goals, I have formulated an innovative and interdisciplinary strategy based on my research experience in bottom-up tissue engineering and microfluidics, and brought together a strong team. First, I will receive an intensive training at the Max Planck Institute for Intelligent Systems on micro-robotics to strengthen the bridge between the fields of micro-robotics and bottom-up tissue engineering. Then, I will get a training at the Harvard Medical School on glioma cell culture and cell extraction from a mouse model. Finally, all these efforts will be integrated into the development of an in vitro 3D glioma-on-a-chip model mimicking the complex in vivo microenvironment of glioma. The successful completion of this timely and innovative project will result in an advanced microphysiological system that will contribute to the competitiveness of Europe in the fields of cancer management, pharmaceutics, and personalized medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences clinical medicine oncology
- engineering and technology other engineering and technologies microtechnology organ on a chip
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.4. - SPREADING EXCELLENCE AND WIDENING PARTICIPATION
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-WF-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
34450 Istanbul
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.