Nanoparticles for the delivery of photodynamic therapy agents
Photodynamic therapy (PDT) is a minimally invasive treatment that combines photosensitising drugs, oxygen and light to kill cancer cells. It is a selective approach with minimal side effects on normal tissues, offering a promising alternative to standard chemotherapy. Despite its approval for clinical use 20 years ago, PDT still finds limited use in most cancer types. The EU-funded BIOnanoPDT project proposes to incorporate phthalocyanine as the photosensitising drug into functionalised biodegradable polymeric nanoparticles to target tumour cells. This will help to address issues associated with the selectivity, aggregation and low water solubility of photosensitising drugs, enhancing the application of PDT in the clinic.