Deliverables Documents, reports (23) 2-Reports on the coordinated development and operational management of the European COVID-19 Adaptive Platform Trials This report will include but is not limited to key recommendations to implement the highlevel strategy defined by the TCB development of new platforms major amendments to existing platforms introduction of new therapeutic domains introduction of new arms development of platforms for prevention or vaccines design of interventional trials based on observational studies expansion to new countries including capacity building for interested sites site selection etc The report will describe the framework that will allow complementarity between trials with regard to the implementation of the highlevel strategy This report will also include the detailed plan on data harmonization between trials to allow common analysis of core data sets Plan for coordination and collaboration with other SARS-COV-2 projects: update 1 First update of D13 SOPs to standardise and harmonise diagnostic test protocols SOPs to standardise and harmonise diagnostic test protocols for detection of the SARS-CoV-2 and/or exclusion of other respiratory viral and bacterial pathogens. Protocol for healthcare professionals survey Understanding healthcare worker views on the management of the COVID-19 pandemic can inform hospital strategies for implementing IPC guidelines, inform communication strategies and can inform strategies to protect healthcare worker physical and psychological health. 1-Reports on the coordinated development and operational management of the European COVID-19 Adaptive Platform Trials This report will include, but is not limited to key recommendations to implement the high-level strategy defined by the TCB - development of new platforms, major amendments to existing platforms, introduction of new therapeutic domains, introduction of new arms, development of platforms for prevention or vaccines, design of interventional trials based on observational studies, expansion to new countries including capacity building for interested sites, site selection etc. The report will describe the framework that will allow complementarity between trials with regard to the implementation of the high-level strategy. This report will also include the detailed plan on data harmonization between trials to allow common analysis of core data sets. 2-Report on the strategic vision and deployment of the European COVID-19 Adaptive Platform Trials This report will include but is not limited to COVID19 international clinical research benchmarking and landscape analysis clinical research gaps for Europe recommendations on priorities in terms of platform trials therapeutic domains and arms It will also include a report on lessonslearnt from OCToPUs First study report of finalized analysis in one treatment domain First study report of finalized analysis in one treatment domain Study updates and summaries Regular study updates will allow to keep all partners informed about study progress Dates of publication cannot be specified as patient enrollment depends on the evolution of the pandemic Plan for coordination and collaboration with other SARS-COV-2 projects: update 2 Second update of D13 UK approved protocol for adapted PRUDENCE trial RECOVER will seek rapid UK approval of the protocol governing the adapted PRUDENCE trial as originally developed in the VALUEDx project Healthcare professionals survey report Interview approaches will be pragmatic and adapted to consider the immediate needs of healthcare professionals and to minimise burden. 1-Report on the strategic vision and deployment of the European COVID-19 Adaptive Platform Trials This report will include, but is not limited to COVID-19 international clinical research benchmarking and landscape analysis, clinical research gaps for Europe, recommendations on priorities in terms of platform trials, therapeutic domains and arms. It will also include a report on lessons-learnt from OCToPUs. Plan for coordination and collaboration with other SARS-COV-2 projects Report to include plan for regular meetings to update on each other's progress, concrete plan on use of common protocols and to ensure harmonization of data collection and coordinated modelling, establishment of inter-project working groups, plan on integration of social sciences capacities and sharing research findings on the dedicated platform (Health Policy Platform/research for policy action). Feasibility questionnaire To facilitate the site selection process, a feasibility questionnaire will be sent that aims to collect study-specific information e.g. on in-house methods and possibilities to implement protocols and methods to detect SARS-COV-2. Validation report on PCR based test Validation report on ready-to-use in-house PCR based test to be used in the clinical trial. Approved protocol for the observational study This protocol for a prospective, non-randomized observational study of CA-ARTI in primary care will include capability to register patients with CA-ARTI in primary care in up to 20 countries, capturing data about the presentation, management, risk factors and (reasons for) suspicion for SARS-CoV-2, treatment, routine investigations performed, outcome of tests, taking a throat and/or nasal swab for research purposes, and capturing clinical outcomes and patient and HCP perceptions. Monthly interim findings from social science related activities In order to rapidly generate evidence for public health and other decision makers, RECOVER will include a brief survey for patients and healthcare workers. Information will be rapidly processed and interim findings fed back to decision makers. Policy brief reporting outcomes from the public survey Interim reports will help guide communication strategies and clinical research planning at local and national levels Communication outputs We will share our (preliminary) results with public health authorities, policy makers and healthcare workers via regular policy briefs and healthcare briefs, summarizing our findings in a concise manner. There is a wealth of other research response efforts being implemented by the wider European infectious diseases research response community. Many of our partners working in Europe, but also in regions outside of Europe (e.g. Africa and Asia) have informed us of their efforts and offered linking their efforts to those conducted in RECOVER. We will reach out to patient organisations such as the International Alliance of Patients’ Organisations (IAPO and European Lung Foundation (ELF) to assess their information needs and how we can best serve these out of RECOVER. RECOVER will target the media with press releases at important time points and milestones. RECOVER's communication activities include the design of a visual identity, online presence (website, social media...), open access publications, news updates, infographics and brochures. Study protocol MERMAIDS 2.0 For Phase II, we will adapt the existing MERMAIDS-ARI protocol (part I) to capture additional aspects relevant to SARS-CoV-2 infections, collect more and targeted biological sampling of confirmed SARS-CoV-2 infections needed for WP5 and WP6, and to enroll children (non-eligible in part I). Second overall study report Second overall study report Report on tools, methodologies and sustainability model for Adaptive Platform Trial design and management, including blueprint for the creation and management of Adaptive Platform Trials in other disease areas beyond COVID-19 This report will include but is not limited to tools for the design of platform trials including statistical methods master protocol template selection of outcome measures and endpoints etc tools for the management of platform trials including sponsorship IP pharmacovigilance data management data sharing cost and business model etc Protocols for collection and transport of specimens This deliverable includes sampling SOPs with details on the choice of samples and sampling collection time points that should be collected in line with the study objectives and SOPs with detailed instructions on sample processing locally, storage and transfer of samples to the central laboratory. Open Research Data Pilot (1) Final study report on social science Final study report on the social science output Publications Other (77) Population-based screening in a municipality after a primary school outbreak of the SARS-CoV-2 Alpha variant, the Netherlands, December 2020–February 2021 Author(s): van Beek et al Published in: PLOS One, 2022 Publisher: PLOS DOI: 10.1371/journal.pone.0276696 Attitudes towards booster, testing and isolation, and their impact on COVID-19 response in winter 2022/2023 in France, Belgium, and Italy: a cross-sectional survey and modelling study Author(s): De Meijere et al. Published in: The Lancet Regional Health - Europe, 2023 Publisher: Elsevier DOI: 10.1016/j.lanepe.2023.100614 Conducting rapid qualitative interview research during the COVID-19 pandemic—Reflections on methodological choices Author(s): Marta Wanat, Aleksandra J. Borek, Caitlin Pilbeam, Sibyl Anthierens, and Sarah Tonkin-Crine Published in: Frontiers in Sociology, 2022 Publisher: Frontiers DOI: 10.3389/fsoc.2022.953872 Highlighting socio-economic constraints on mobility reductions during COVID-19 restrictions in France can inform effective and equitable pandemic response Author(s): Eugenio Valdano, Jonggul Lee, Shweta Bansal, Stefania Rubrichi, Vittoria Colizza Published in: Journal of Travel Medicine, 2021 Publisher: Oxford Academic DOI: 10.1093/jtm/taab045 Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the ISARIC WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study Author(s): Reyes, Luis Felipe et al Published in: ERJ Open Research, 2022 Publisher: ERS DOI: 10.1183/23120541.00552-2021 Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM Author(s): Yifan Wang, Cong Xu, Yanxing Wang, Qin Hong, Chao Zhang, Zuyang Li, Shiqi Xu, Qinyu Zuo, Caixuan Liu, Zhong Huang, Yao Cong Published in: Nature Communications, Issue Article number: 7345 (2021), 2021 Publisher: Springer Nature DOI: 10.1038/s41467-021-27350-0 Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients Author(s): GeurtsvanKessel CH, Geers D, Schmitz KS, Mykytyn AZ, Lamers MM, Bogers S, Scherbeijn S, Gommers L, Sablerolles RSG, Nieuwkoop NN, Rijsbergen LC, van Dijk LLA, de Wilde J, Alblas K, Breugem TI, Rijnders BJA, de Jager H, Weiskopf D, van der Kuy PHM, Sette A, Koopmans MPG, Grifoni A, Haagmans BL, de Vries RD Published in: Sci Immunol, 2022 Publisher: AAAS DOI: 10.1126/sciimmunol.abo2202 Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta Author(s): Ulrich L, Halwe NJ, Taddeo A, Ebert N, Schön J, Devisme C, Trüeb BS, Hoffmann B, Wider M, Fan X, Bekliz M, Essaidi-Laziosi M, Schmidt ML, Niemeyer D, Corman VM, Kraft A, Godel A, Laloli L, Kelly JN, Calderon BM, Breithaupt A, Wylezich C, Berenguer Veiga I, Gultom M, Osman S, Zhou B, Adea K, Meyer B, Eberhardt CS, Thomann L, Gsell M, Labroussaa F, Jores J, Summerfield A, Drosten C, Eckerle IA, We Published in: Nature, 2022 Publisher: Springer Nature DOI: 10.1038/s41586-021-04342-0 The value of open-source clinical science in pandemic response: lessons from ISARIC Author(s): The ISARIC Clinical Characterisation Group Published in: Lancet Infectious Diseases, 2021 Publisher: Elsevier DOI: 10.1016/s1473-3099(21)00565-x Methodological and ethical considerations when conducting qualitative interview research with healthcare professionals: reflections and recommendations as a result of a pandemic Author(s): Pilbeam, C., Anthierens, S., Vanderslott, S., Tonkin-Crine, S., & Wanat, M. Published in: International Journal of Qualitative Methods, 2022 Publisher: Sage Journals DOI: 10.1177/16094069221077763 Transmission of SARS-CoV-2 within households: a remote prospective cohort study in European countries Author(s): Janneke D. M. Verberk, Marieke L. A. de Hoog, Ilse Westerhof, Sam van Goethem, Christine Lammens, Greet Ieven, Erwin de Bruin, Dirk Eggink, Julia A. Bielicki, Samuel Coenen, Janko van Beek, Marc J. M. Bonten, Herman Goossens & Patricia C. J. L. Bruijning-Verhagen Published in: European Journal of Epidemiology, 2022 Publisher: Springer DOI: 10.1007/s10654-022-00870-9 Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19. Author(s): Ewan C. Goligher, Patrick R. Lawler, Thomas P. Jensen, et al Published in: JAMA, 2023 Publisher: JAMA Network DOI: 10.1001/jama.2023.3651 Monitoring key epidemiological parameters of SARS-CoV-2 transmission Author(s): Kraemer MUG, Pybus OG, Fraser C, Cauchemez S, Rambaut A, Cowling BJ Published in: Nature Medicine, 2021 Publisher: Springer Nature DOI: 10.1038/s41591-021-01545-w Modelling COVID-19 in school settings to evaluate prevention and control protocols Author(s): Colosi et al. Published in: Anaesthesia Critical Care & Pain Medicine, 2022 Publisher: Science Direct DOI: 10.1016/j.accpm.2022.101047 Monitoring the proportion of the population infected by SARS-CoV-2 using age-stratified hospitalization and serological data: a modelling study Author(s): Hoze N, Paireau J, Lapidus N, Tran Kiem C, Salje H, Severi G, Touvier M, Zins M, de Lamballerie X, Lévy-Bruhl D, Carrat F, Cauchemez S Published in: Lancet Public Health, 2021 Publisher: Elsevier DOI: 10.1016/s2468-2667(21)00064-5 Early assessment of diffusion and possible expansion of SARS-CoV-2 lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021 Author(s): Gaymard A, Bosetti P, Feri A, Destras G, Enouf V, Andronico A, Burrel S, Behillil S, Sauvage C, Bal A, Morfin F, Van Der Werf S, Josset L, ANRS MIE AC43 COVID-19, French viro COVID group, Blanquart F, Coignard B, Cauchemez S, Lina B Published in: Eurosurveillance, 2021 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2021.26.9.2100133 SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies Author(s): Reincke SM, Yuan M, Kornau HC, Corman VM, van Hoof S, Sánchez-Sendin E, Ramberger M, Yu W, Hua Y, Tien H, Schmidt ML, Schwarz T, Jeworowski LM, Brandl SE, Rasmussen HF, Homeyer MA, Stöffler L, Barner M, Kunkel D, Huo S, Horler J, von Wardenburg N, Kroidl I, Eser TM, Wieser A, Geldmacher C, Hoelscher M, Gänzer H, Weiss G, Schmitz D, Drosten C, Prüss H, Wilson IA, Kreye J Published in: Science, 2022 Publisher: AAAS DOI: 10.1126/science.abm5835 Investigations on SARS-CoV-2 and other coronaviruses in mink farms in France at the end of the first year of COVID-19 pandemic. Author(s): Wasniewski M, Boué F, Richomme C, Simon-Lorière E, Van der Werf S, Donati F, Enouf V, Blanchard Y, Beven V, Leperchois E, Leterrier B, Corbet S, Le Gouil M, Monchatre-Leroy E, Picard-Meyer E. Published in: bioRxiv, 2023 Publisher: preprint DOI: 10.1101/2023.02.02.526749 Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial Author(s): Writing Committee for the REMAP-CAP Investigators Published in: JAMA, 2022 Publisher: JAMA Network DOI: 10.1001/jama.2022.23257 A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern Author(s): van Gils MJ, van Willigen HDG, Wynberg E, Han AX, van der Straten K, Burger JA, Poniman M, Oomen M, Tejjani K, Bouhuijs JH, Verveen A, Lebbink R, Dijkstra M, Appelman B, Lavell AHA, Caniels TG, Bontjer I, van Vught LA, Vlaar APJ, Sikkens JJ, Bomers MK, Russell CA, Kootstra NA, Sanders RW, Prins M, de Bree GJ, de Jong MD Published in: Cell Rep Med, 2021 Publisher: Elsevier DOI: 10.1016/j.xcrm.2021.100486 Impact of contact data resolution on the evaluation of interventions in mathematical models of infectious diseases Author(s): Contreras et al. Published in: Journal of the Royal Society, 2022 Publisher: Royal Society Publishing DOI: 10.1098/rsif.2022.0164 Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19: A network meta-analysis Author(s): Peter J. Godolphin, David J. Fisher, Lindsay R. Berry, Lennie P. G. Derde, Janet V. Diaz, Anthony C. Gordon, Elizabeth Lorenzi, John C. Marshall, Srinivas Murthy, Manu Shankar-Hari, Jonathan A. C. Sterne, Jayne F. Tierney, Claire L. Vale Published in: Plos One, 2022 Publisher: PLOS DOI: 10.1371/journal.pone.0270668 Impact of January 2021 curfew measures on SARS-CoV-2 B.1.1.7 circulation in France Author(s): Laura Di Domenico, Chiara E Sabbatini, Giulia Pullano, Daniel Lévy-Bruhl, Vittoria Colizza Published in: Eurosurveillance, 2021 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2021.26.15.2100272 Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination Author(s): Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Th Published in: Science, 2021 Publisher: AAAS DOI: 10.1126/science.abh1823 Considerable escape of SARS-CoV-2 Omicron to antibody neutralization. Author(s): Planas D, Saunders N, Maes P, Guivel-Benhassine F, Planchais C, Buchrieser J, Bolland WH, Porrot F, Staropoli I, Lemoine F, Péré H, Veyer D, Puech J, Rodary J, Baele G, Dellicour S, Raymenants J, Gorissen S, Geenen C, Vanmechelen B, Wawina-Bokalanga T, Martí-Carreras J, Cuypers L, Sève A, Hocqueloux L, Prazuck T, Rey FA, Simon-Loriere E, Bruel T, Mouquet H, André E, Schwartz O. Published in: Nature, 2022 Publisher: nature DOI: 10.1038/s41586-021-04389-z Projecting the COVID-19 epidemic risk in France for the summer 2021 Author(s): Mattia Mazzoli, Eugenio Valdano, Vittoria Colizza Published in: Journal of travel medicine, 2021 Publisher: Oxford Academic DOI: 10.1093/jtm/taab129 Evolution of outcomes for patients hospitalised during the first 9 months of the SARS-CoV-2 pandemic in France: A retrospective national surveillance data analysis Author(s): Lefrancq N, Paireau J, Hozé N, Courtejoie N, Yazdanpanah Y, Bouadma L, Boëlle PY, Chereau F, Salje H, Cauchemez S Published in: The Lancet Regional Health - Europe, 2021 Publisher: Elsevier DOI: 10.1016/j.lanepe.2021.100087 Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021 Author(s): Tober-Lau P, Schwarz T, Hillus D, Spieckermann J, Helbig ET, Lippert LJ, Thibeault C, Koch W, Bergfeld L, Niemeyer D, Mühlemann B, Conrad C, Kasper S, Münn F, Kunitz F, Jones TC, Suttorp N, Drosten C, Sander LE, Kurth F, Corman VM Published in: Emerg Infect Dis, 2021 Publisher: CDC DOI: 10.3201/eid2708.210887 Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort Author(s): ISARIC Clinical Characterisation Group et al Published in: eLife, 2021 Publisher: eLife DOI: 10.7554/elife.70970 SARS-CoV-2 transmission across age groups in France and implications for control Author(s): Tran Kiem C, Bosetti P, Paireau J, Crepey P, Salje H, Lefrancq N, Fontanet A, Benamouzig D, Boelle PY, Desenclos JC, Opatowski L, Cauchemez S Published in: Nature Communications, 2021 Publisher: Springer Nature DOI: 10.1038/s41467-021-27163-1 Screening and vaccination against COVID-19 to minimise school closure: a modelling study Author(s): Colosi et al Published in: The Lancet Infectious Diseases, 2022 Publisher: Science Direct DOI: 10.1016/s1473-3099(22)00138-4 X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 Author(s): T. Asano et al Published in: Science Immunology, 2021 Publisher: AAAS DOI: 10.1126/sciimmunol.abl4348 The experiences of patients ill with COVID-19-like symptoms and the role of testing for SARS-CoV-2 in supporting them: A qualitative study in eight European countries during the first wave of the pandemic Author(s): Hoste ME, Wanat M, Gobat N, et al. Published in: European Journal of General Practice, 2023 Publisher: Taylor and Francis DOI: 10.1080/13814788.2023.2212904 Drivers and impact of the early silent invasion of SARS-CoV-2 Alpha Author(s): Faucher et al. Published in: 2023 Publisher: MedrXiv DOI: 10.1101/2023.08.21.23293488 High incidence of sotrovimab resistance and viral persistence after treatment of immunocompromised patients infected with the SARS-CoV-2 Omicron variant Author(s): Huygens et al Published in: Clinical Infectious Diseases, 2022 Publisher: Oxford Academic DOI: 10.1093/cid/ciac601 Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. Author(s): Writing Committee for the REMAP-CAP Investigators Published in: JAMA, 2023 Publisher: JAMA Network DOI: 10.1001/jama.2023.4480 Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany Author(s): Schwarz T, Tober-Lau P, Hillus D, Helbig ET, Lippert LJ, Thibeault C, Koch W, Landgraf I, Michel J, Bergfeld L, Niemeyer D, Mühlemann B, Conrad C, Dang-Heine C, Kasper S, Münn F, Kappert K, Nitsche A, Tauber R, Schmidt S, Kopankiewicz P, Bias H, Seybold J, von Kalle C, Jones TC, Suttorp N, Drosten C, Sander LE, Corman VM, Kurth F Published in: Emerg Infect Dis, 2021 Publisher: CDC DOI: 10.3201/eid2708.211145 The experience of European hospital-based health care workers on following infection prevention and control procedures and their well-being during the first wave of the COVID-19 pandemic Author(s): Denise van Hout, Paul Hutchinson, Marta Wanat, Caitlin Pilbeam, Herman Goossens, Sibyl Anthierens, Sarah Tonkin-Crine, Nina Gobat Published in: PLoS ONE, 2022 Publisher: PLoS ONE DOI: 10.1371/journal.pone.0245182 Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses Author(s): Schulze, J., Mache, C., Balázs, A., Frey, D., Niemeyer, D., Olze, H., Dommerich, S., Drosten, C., Hocke, A. C., Mall, M. A., Hippenstiel, S., & Wolff, T Published in: The Journal of infectious diseases, 2021 Publisher: Oxford Academic DOI: 10.1093/infdis/jiab523 The European clinical research response to optimise treatment of patients with COVID-19: lessons learned, future perspective, and recommendations Author(s): Goossens H, Horby P, Derde L, Bonten M Published in: Lancet Infect Dis, 2021 Publisher: The Lancet DOI: 10.1016/s1473-3099(21)00705-2 Impact of mass testing during an epidemic rebound of SARS-CoV-2: a modelling study using the example of France Author(s): Bosetti P, Tran Kiem C, Yazdanpanah Y, Fontanet A, Lina B, Colizza V, Cauchemez S Published in: Eurosurveillance, 2021 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2020.26.1.2001978 Conditionality of COVID-19 vaccine acceptance in European countries Author(s): Leonardo W. Heyerdahl, Muriel Vray, Benedetta Lana, Nastassia Tvardik, Nina Gobat, Marta Wanat, Sarah Tonkin-Crine, Sibyl Anthierens, Herman Goossens, Tamara Giles-Vernick Published in: Vaccine, 2022 Publisher: Elsevier DOI: 10.1016/j.vaccine.2022.01.054 Modelling the end of a Zero-COVID strategy using nirmatrelvir/ritonavir, vaccination and NPIs in Wallis and Futuna Author(s): Brault et al Published in: The Lancet Regional Health, 2023 Publisher: Elsevier DOI: 10.1016/j.lanwpc.2022.100634 An early warning system for emerging SARS-CoV-2 variants Author(s): Subissi L, von Gottberg A, Thukral L, Worp N, Oude Munnink BB, Rathore S, Abu-Raddad LJ, Aguilera X, Alm E, Archer BN, Attar Cohen H, Barakat A, Barclay WS, Bhiman JN, Caly L, Chand M, Chen M, Cullinane A, de Oliveira T, Drosten C, Druce J, Effler P, El Masry I, Faye A, Gaseitsiwe S, Ghedin E, Grant R, Haagmans BL, Herring BL, Iyer SS, Kassamali Z, Kakkar M, Kondor RJ, Leite JA, Leo YS, Leung GM, Published in: Nature Medicine, 2022 Publisher: Nature DOI: 10.1038/s41591-022-01836-w Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2. Author(s): Saunders N, Planas D, Bolland WH, Rodriguez C, Fourati S, Buchrieser J, Planchais C, Prot M, Staropoli I, Guivel-Benhassine F, Porrot F, Veyer D, Péré H, Robillard N, Saliba M, Baidaliuk A, Seve A, Hocqueloux L, Prazuck T, Rey FA, Mouquet H, Simon-Lorière E, Bruel T, Pawlotsky JM, Schwartz O. Published in: 2022 Publisher: Science Direct DOI: 10.1016/j.ebiom.2022.103934 Seasonal coronavirus-specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19 Author(s): Aguilar-Bretones M, Westerhuis BM, Raadsen MP, de Bruin E, Chandler FD, Okba NM, Haagmans BL, Langerak T, Endeman H, van den Akker JP, Gommers DA, van Gorp EC, GeurtsvanKessel CH, de Vries RD, Fouchier RA, Rockx BH, Koopmans MP, van Nierop GP Published in: The Journal of Clinical Investigation, 2021 Publisher: ASCI DOI: 10.1172/jci150613 Continuation of therapeutic dose heparin for critically ill patients with COVID-19. Author(s): Charlotte A. Bradbury, Patrick R. Lawler, Bryan J. McVerry & Ryan Zarychanski on behalf of the REMAP-C. A. P. Investigators Published in: Intensive care medicine, 2023 Publisher: Springer DOI: 10.1007/s00134-023-07095-8 Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2. Author(s): Planchais C, Fernández I, Bruel T, de Melo GD, Prot M, Beretta M, Guardado-Calvo P, Dufloo J, Molinos-Albert LM, Backovic M, Chiaravalli J, Giraud E, Vesin B, Conquet L, Grzelak L, Planas D, Staropoli I, Guivel-Benhassine F, Hieu T, Boullé M, Cervantes-Gonzalez M, Ungeheuer MN, Charneau P, van der Werf S, Agou F; French COVID Cohort Study Group; CORSER Study Group; Dimitrov JD, Simon-Lorière E, Published in: Journal of Experimental Medicine, 2022 Publisher: Rockefeller University Press DOI: 10.1084/jem.20220638 Minimising school disruption under high incidence conditions due to the Omicron variant in France, Switzerland, Italy, in January 2022. Author(s): Colosi et. al. Published in: Eurosurveillance, 2022 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2023.28.5.2200192 Regular universal screening for SARS-CoV-2 infection may not allow reopening of society after controlling a pandemic wave Author(s): MCJ Bootsma, ME Kretzschmar, G Rozhnova, JAP Heesterbeek, JAJW Kluytmans, MJM Bonten Published in: medrxiv, Issue Preprint server, 2020 Publisher: BMJ DOI: 10.1101/2020.11.18.20233122 Platform trials as the way forward in infectious disease' clinical research: the case of coronavirus disease 2019 Author(s): Juan M. Pericas, Lennie P.G. Derde, Scott M. Berry, on behalf of EU-PEARL and REMAP-CAP investigators Published in: Clinical Microbiology and Infection, 2023 Publisher: Elsevier DOI: 10.1016/j.cmi.2022.11.022 Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody Author(s): 39. Li T, Cai H, Zhao Y, Li Y, Lai Y, Yao H, Liu LD, Sun Z, van Vlissingen MF, Kuiken T, GeurtsvanKessel CH, Zhang N, Zhou B, Lu L, Gong Y, Qin W, Mondal M, Duan B, Xu S, Richard AS, Raoul H, Chen J, Xu C, Wu L, Zhou H, Huang Z, Zhang X, Li J, Wang Y, Bi Y, Rockx B, Chen J, Meng FL, Lavillette D, Li D Published in: EMBO Molecular Medicine, 2021 Publisher: EMBOpress DOI: 10.15252/emmm.202114544 Prospective SARS-CoV-2 cohort study among primary health care providers during the second COVID-19 wave in Flanders, Belgium Author(s): Mariën, J., Ceulemans A., Bakokimi D, Lammens C., Ieven M., Heytens S., De Sutter A., Verbakel, J. Y., Van den Bruel A., Goossens H., Van Damme P., Arië, K. K. , and Coenen S. Published in: Family Practice, 2022 Publisher: Oxford Academic DOI: 10.1093/fampra/cmab094 Rapid characterization of a Delta-Omicron SARS-CoV-2 recombinant detected in Europe Author(s): Simon-Loriere et al Published in: preprint, 2022 Publisher: Researchsquare DOI: 10.21203/rs.3.rs-1502293/v1 The impact of variant and vaccination on SARS-CoV-2 symptomatology; three prospective household cohorts Author(s): Ilse Westerhof, Marieke de Hoog, Margareta Ieven, Christine Lammens, Janko van Beek, Ganna Rozhnova, Dirk Eggink, Sjoerd Euser, Joanne Wildenbeest, Liesbeth Duijts, Marlies van Houten, Herman Goossens, Carlo Giaquinto, Patricia Bruijning–Verhagen Published in: International Journal of Infectious Diseases, 2023 Publisher: Science Direct DOI: 10.1016/j.ijid.2022.12.018 Screening and vaccination against COVID-19 to minimize school closure: a modeling study Author(s): Elisabetta Colosi, Giulia Bassignana, Diego Andrés Contreras, Canelle Poirier, Pierre-Yves Boëlle, Simon Cauchemez, Yazdan Yazdanpanah, Bruno Lina, Arnaud Fontanet, Alain Barrat, Vittoria Colizza Published in: Lancet Infectious Diseases, 2021 Publisher: BMJ Yale DOI: 10.1101/2021.08.15.21261243 Thrombosis pathways in COVID-19 vs. influenza-associated ARDS: A targeted proteomics approach Author(s): Emma Rademaker, Dennis J. Doorduijn, Nuray Kusadasi, Coen Maas, Julia Drylewicz, Albert Huisman, Imo E. Hoefer, Marc J. M. Bonten, Lennie P. G. Derde, Suzan H. M. Rooijakkers, Olaf L. 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G., McVerry, Bryan J., Russell, James A., van de Veerdonk, Frank L Published in: Critical Care Medicine, 2022 Publisher: Society of Critical Care Medicine DOI: 10.1097/ccm.0000000000005567 Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variants Author(s): Mertens J. Coppens J., Loens K., Le Mercier M., Xavier B. B., Lammens C., Vandamme S., Jansens H., Goossens H., and Matheeussen V Published in: Clinical Microbiology and Infection, 2022 Publisher: Elsevier DOI: 10.1016/j.cmi.2021.09.007 A modelling study investigating short and medium-term challenges for COVID-19 vaccination: From prioritisation to the relaxation of measures Author(s): Tran Kiem C, Massonnaud CR, Levy-Bruhl D, Poletto C, Colizza V, Bosetti P, Fontanet A, Gabet A, Olié V, Zanetti L, Boëlle PY, Crépey P, Cauchemez S Published in: EClinicalMedicine, 2021 Publisher: Lancet DOI: 10.1016/j.eclinm.2021.101001 Clinical diagnosis of SARS-CoV-2 infection: An observational study of respiratory tract infection in primary care in the early phase of the pandemic Author(s): Alike W. van der Velden, Milensu Shanyinde, Emily Bongard, Femke Böhmer, Slawomir Chlabicz, Annelies Colliers, Ana García-Sangenís, Lile Malania, Jozsef Pauer, Angela Tomacinschii, Ly-Mee Yu, Katherine Loens, Margareta Ieven, Theo J. Verheij, Herman Goossens, Akke Vellinga, Christopher C. Butler Published in: European Journal of General Practice, 2023 Publisher: Taylor and Francis DOI: 10.1080/13814788.2023.2270707 Randomised clinical trials in critical care: past, present and future Author(s): Anders Granholm, Waleed Alhazzani, Lennie P. G. Derde, Derek C. Angus, Fernando G. Zampieri, Naomi E. Hammond, Rob Mac Sweeney, Sheila N. Myatra, Elie Azoulay, Kathryn Rowan, Paul J. Young, Anders Perner & Morten Hylander Møller Published in: Intensive Care Medicine, 2022 Publisher: Springer DOI: 10.1007/s00134-021-06587-9 From more testing to smart testing: data-guided SARS-CoV-2 testing choices, the Netherlands, May to September 2020 Author(s): van Beek Janko, Igloi Zsofia, Boelsums Timo, Fanoy Ewout, Gotz Hannelore, Molenkamp Richard, van Kampen Jeroen, GeurtsvanKessel Corine, van der Eijk Annemiek A, van de Vijver David, Koopmans Marion Published in: Eurosurveillance, 2022 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2022.27.8.2100702 Benefits and risks associated with different uses of the COVID-19 vaccine Vaxzevria: a modelling study, France, May to September 2021 Author(s): Tran Kiem C, Andronico A, Bosetti P, Paireau J, Alter L, Boëlle PY, Fontanet A, Lévy-Bruhl D, Cauchemez S Published in: Eurosurveillance, 2021 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2021.26.26.2100533 Transmission of SARS-CoV-2 within households: a prospective cohort study in the Netherlands and Belgium – Interim results Author(s): JDM Verberk, MLA de Hoog, I Westerhof, S Van Goethem, C Lammens, M Ieven, E de Bruin, J Bielicki, S Coenen, J van Beek, M Bonten, H Goossens, PCJL Bruijning-Verhagen Published in: Medrxiv, 2021 Publisher: BMJ Yale DOI: 10.1101/2021.04.23.21255846 The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies Author(s): J. Manry et al Published in: Research Square, 2022 Publisher: Research Square Company DOI: 10.21203/rs.3.rs-1225906/v1 Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages Author(s): Touret F, Giraud E, Bourret J, Donati F, Tran-Rajau J, Chiaravalli J, Lemoine F, Agou F, Simon-Lorière E, van der Werf S, de Lamballerie X. Published in: 2023 Publisher: Science Direct DOI: 10.1016/j.isci.2023.106413 Adherence and sustainability of interventions informing optimal control against the COVID-19 pandemic Author(s): Laura Di Domenico, Chiara E Sabbatini, Pierre-Yves Boëlle, Chiara Poletto, Pascal Crépey, Juliette Paireau, Simon Cauchemez, François Beck, Harold Noel, Daniel Lévy-Bruhl, Vittoria Colizza Published in: Communications Medicine, 2021 Publisher: Springer Nature DOI: 10.1038/s43856-021-00057-5 SARS-CoV-2-related bat virus behavior in human-relevant models sheds light on the origin of COVID-19 Author(s): Temmam S, Montagutelli X, Herate C, Donati F, Regnault B, Attia M, Baquero Salazar E, Chretien D, Conquet L, Jouvion G, Pipoli Da Fonseca J, Cokelaer T, Amara F, Relouzat F, Naninck T, Lemaitre J, Derreudre-Bosquet N, Pascal Q, Bonomi M, Bigot T, Munier S, Rey FA, Le Grand R, van der Werf S, Eloit M. Published in: 2023 Publisher: EMBO Press DOI: 10.15252/embr.202256055 Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths Author(s): Bastard P et al Published in: Science Immunology, 2021 Publisher: American Association for the Advancement of Science DOI: 10.1126/sciimmunol.abl4340 Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands Author(s): Sikkema et al Published in: Viruses, 2023 Publisher: MDPI DOI: 10.3390/v15010212 Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study Author(s): Mühlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Müller MA; Pa-COVID-19 collaborative study group, Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F Published in: Clin Microbiol Infect, 2021 Publisher: Elsevier DOI: 10.1016/j.cmi.2021.06.008 Agent-based modelling of reactive vaccination of workplaces and schools against COVID-19 Author(s): Faucher et al Published in: Nature Communications, 2022 Publisher: Springer DOI: 10.1038/s41467-022-29015-y Evaluating the impact of curfews and other measures on SARS-CoV-2 transmission in French Guiana Author(s): Andronico A, Tran Kiem C, Paireau J, Succo T, Bosettit P, Lefrancq N, Nacher M, Djossou F, Sanna A, Flamand C, Salje H, Rousseau C, Cauchemez S Published in: Nature Communications, 2021 Publisher: Nature Springer DOI: 10.1038/s41467-021-21944-4 Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial Author(s): REMAP-CAP Writing Committee for the REMAP-CAP Investigators Published in: JAMA, 2022 Publisher: JAMA Network DOI: 10.1001/jama.2022.2910 Peer reviewed articles (23) Following the science? Views from scientists on government advisory boards during the COVID-19 pandemic: a qualitative interview study in five European countries Author(s): Elien Colman, Marta Wanat, Herman Goossens, Sarah Tonkin-Crine, Sibyl Anthierens Published in: BMJ Global Health, Issue 6/9, 2021, Page(s) e006928, ISSN 2059-7908 Publisher: BMJ DOI: 10.1136/bmjgh-2021-006928 International external quality assessment for SARS-CoV-2 molecular detection and survey on clinical laboratory preparedness during the COVID-19 pandemic, April/May 2020 Author(s): Veerle Matheeussen, Victor M Corman, Oliver Donoso Mantke, Elaine McCulloch, Christine Lammens, Herman Goossens, Daniela Niemeyer, Paul S Wallace, Paul Klapper, Hubert GM Niesters, Christian Drosten, Margareta Ieven Published in: Eurosurveillance, Issue 25/27, 2020, ISSN 1560-7917 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2020.25.27.2001223 Lockdown as a last resort option in case of COVID-19 epidemic rebound: a modelling study Author(s): Cécile Tran Kiem, Pascal Crépey, Paolo Bosetti, Daniel Levy Bruhl, Yazdan Yazdanpanah, Henrik Salje, Pierre-Yves Boëlle, Simon Cauchemez Published in: Eurosurveillance, Issue 26/22, 2021, ISSN 1560-7917 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2021.26.22.2001536 Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020 Author(s): Isabelle Sermet-Gaudelus, Sarah Temmam, Christèle Huon, Sylvie Behillil, Vincent Gajdos, Thomas Bigot, Thibaut Lurier, Delphine Chrétien, Marija Backovic, Agnès Delaunay-Moisan, Flora Donati, Mélanie Albert, Elsa Foucaud, Bettina Mesplées, Grégoire Benoist, Albert Faye, Marc Duval-Arnould, Célia Cretolle, Marina Charbit, Mélodie Aubart, Johanne Auriau, Mathie Lorrot, Dulanjalee Kariyawasam Published in: Eurosurveillance, Issue 26/13, 2021, ISSN 1560-7917 Publisher: Eurosurveillance DOI: 10.2807/1560-7917.es.2021.26.13.2001782 Transformation of primary care during the COVID-19 pandemic: experiences of healthcare professionals in eight European countries Author(s): Marta Wanat, Melanie Hoste, Nina Gobat, Marilena Anastasaki, Femke Böhmer, Slawomir Chlabicz, Annelies Colliers, Karen Farrell, Maria-Nefeli Karkana, John Kinsman, Christos Lionis, Ludmila Marcinowicz, Katrin Reinhardt, Ingmarie Skoglund, Pär-Daniel Sundvall, Akke Vellinga, Theo JM Verheij, Herman Goossens, Christopher C Butler, Alike van der Velden, Sibyl Anthierens, Sarah Tonkin-Crine Published in: British Journal of General Practice, Issue 71/709, 2021, Page(s) e634-e642, ISSN 0960-1643 Publisher: Royal College of General Practitioners DOI: 10.3399/bjgp.2020.1112 Monitoring approaches for health-care workers during the COVID-19 pandemic Author(s): Julia A Bielicki, Xavier Duval, Nina Gobat, Herman Goossens, Marion Koopmans, Evelina Tacconelli, Sylvie van der Werf Published in: The Lancet Infectious Diseases, Issue 20/10, 2020, Page(s) e261-e267, ISSN 1473-3099 Publisher: The Lancet Publishing Group DOI: 10.1016/s1473-3099(20)30458-8 Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 Author(s): REMAP-CAP Investigators, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, May Published in: New England Journal of Medicine, Issue 384/16, 2021, Page(s) 1491-1502, ISSN 0028-4793 Publisher: Massachusetts Medical Society DOI: 10.1056/nejmoa2100433 Experiences and needs of persons living with a household member infected with SARS-CoV-2: A mixed method study Author(s): Janneke D. M. Verberk, Sibyl A. Anthierens, Sarah Tonkin-Crine, Herman Goossens, John Kinsman, Marieke L. A. de Hoog, Julia A. Bielicki, Patricia C. J. L. Bruijning-Verhagen, Nina H. Gobat Published in: PLOS ONE, Issue 16/3, 2021, Page(s) e0249391, ISSN 1932-6203 Publisher: Public Library of Science DOI: 10.1371/journal.pone.0249391 A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection Author(s): Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. 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Nieuwenhuijse, Robert Jan Molenaar, Emmanuelle Munger, Richard Molenkamp, Arco van der Spek, Paulien Tolsma, Ariene Rietveld, Miranda Brouwer, Noortje Bouwmeester-Vincken, Frank Harders, Renate Hakze-van der Honing, Marjolein C. A. Wegdam-Blans, Ruth J. Bouwstra, Corine GeurtsvanKessel, Annemiek A. van der Eijk, Francisca C. Velkers, Lidwien A. M. 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