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Rapid European SARS-CoV-2 Emergency research Response

Deliverables

SOPs to standardise and harmonise diagnostic test protocols

SOPs to standardise and harmonise diagnostic test protocols for detection of the SARS-CoV-2 and/or exclusion of other respiratory viral and bacterial pathogens.

Protocol for healthcare professionals survey

Understanding healthcare worker views on the management of the COVID-19 pandemic can inform hospital strategies for implementing IPC guidelines, inform communication strategies and can inform strategies to protect healthcare worker physical and psychological health.

1-Reports on the coordinated development and operational management of the European COVID-19 Adaptive Platform Trials

This report will include, but is not limited to key recommendations to implement the high-level strategy defined by the TCB - development of new platforms, major amendments to existing platforms, introduction of new therapeutic domains, introduction of new arms, development of platforms for prevention or vaccines, design of interventional trials based on observational studies, expansion to new countries including capacity building for interested sites, site selection etc. The report will describe the framework that will allow complementarity between trials with regard to the implementation of the high-level strategy. This report will also include the detailed plan on data harmonization between trials to allow common analysis of core data sets.

First study report of finalized analysis in one treatment domain

First study report of finalized analysis in one treatment domain

Healthcare professionals survey report

Interview approaches will be pragmatic and adapted to consider the immediate needs of healthcare professionals and to minimise burden.

1-Report on the strategic vision and deployment of the European COVID-19 Adaptive Platform Trials

This report will include, but is not limited to COVID-19 international clinical research benchmarking and landscape analysis, clinical research gaps for Europe, recommendations on priorities in terms of platform trials, therapeutic domains and arms. It will also include a report on lessons-learnt from OCToPUs.

Plan for coordination and collaboration with other SARS-COV-2 projects

Report to include plan for regular meetings to update on each other's progress, concrete plan on use of common protocols and to ensure harmonization of data collection and coordinated modelling, establishment of inter-project working groups, plan on integration of social sciences capacities and sharing research findings on the dedicated platform (Health Policy Platform/research for policy action).

Feasibility questionnaire

To facilitate the site selection process, a feasibility questionnaire will be sent that aims to collect study-specific information e.g. on in-house methods and possibilities to implement protocols and methods to detect SARS-COV-2.

Validation report on PCR based test

Validation report on ready-to-use in-house PCR based test to be used in the clinical trial.

Approved protocol for the observational study

This protocol for a prospective, non-randomized observational study of CA-ARTI in primary care will include capability to register patients with CA-ARTI in primary care in up to 20 countries, capturing data about the presentation, management, risk factors and (reasons for) suspicion for SARS-CoV-2, treatment, routine investigations performed, outcome of tests, taking a throat and/or nasal swab for research purposes, and capturing clinical outcomes and patient and HCP perceptions.

Monthly interim findings from social science related activities

In order to rapidly generate evidence for public health and other decision makers, RECOVER will include a brief survey for patients and healthcare workers. Information will be rapidly processed and interim findings fed back to decision makers.

Communication outputs

We will share our (preliminary) results with public health authorities, policy makers and healthcare workers via regular policy briefs and healthcare briefs, summarizing our findings in a concise manner. There is a wealth of other research response efforts being implemented by the wider European infectious diseases research response community. Many of our partners working in Europe, but also in regions outside of Europe (e.g. Africa and Asia) have informed us of their efforts and offered linking their efforts to those conducted in RECOVER. We will reach out to patient organisations such as the International Alliance of Patients’ Organisations (IAPO and European Lung Foundation (ELF) to assess their information needs and how we can best serve these out of RECOVER. RECOVER will target the media with press releases at important time points and milestones. RECOVER's communication activities include the design of a visual identity, online presence (website, social media...), open access publications, news updates, infographics and brochures.

Study protocol MERMAIDS 2.0

For Phase II, we will adapt the existing MERMAIDS-ARI protocol (part I) to capture additional aspects relevant to SARS-CoV-2 infections, collect more and targeted biological sampling of confirmed SARS-CoV-2 infections needed for WP5 and WP6, and to enroll children (non-eligible in part I).

Second overall study report

Second overall study report

Protocols for collection and transport of specimens

This deliverable includes sampling SOPs with details on the choice of samples and sampling collection time points that should be collected in line with the study objectives and SOPs with detailed instructions on sample processing locally, storage and transfer of samples to the central laboratory.

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Publications

Highlighting socio-economic constraints on mobility reductions during COVID-19 restrictions in France can inform effective and equitable pandemic response

Author(s): Eugenio Valdano, Jonggul Lee, Shweta Bansal, Stefania Rubrichi, Vittoria Colizza
Published in: Journal of Travel Medicine, 2021
Publisher: Oxford Academic
DOI: 10.1093/jtm/taab045

Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM

Author(s): Yifan Wang, Cong Xu, Yanxing Wang, Qin Hong, Chao Zhang, Zuyang Li, Shiqi Xu, Qinyu Zuo, Caixuan Liu, Zhong Huang, Yao Cong
Published in: Nature Communications, Article number: 7345 (2021), 2021
Publisher: Springer Nature
DOI: 10.1038/s41467-021-27350-0

Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients

Author(s): GeurtsvanKessel CH, Geers D, Schmitz KS, Mykytyn AZ, Lamers MM, Bogers S, Scherbeijn S, Gommers L, Sablerolles RSG, Nieuwkoop NN, Rijsbergen LC, van Dijk LLA, de Wilde J, Alblas K, Breugem TI, Rijnders BJA, de Jager H, Weiskopf D, van der Kuy PHM, Sette A, Koopmans MPG, Grifoni A, Haagmans BL, de Vries RD
Published in: Sci Immunol, 2022
Publisher: AAAS
DOI: 10.1126/sciimmunol.abo2202

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

Author(s): Ulrich L, Halwe NJ, Taddeo A, Ebert N, Schön J, Devisme C, Trüeb BS, Hoffmann B, Wider M, Fan X, Bekliz M, Essaidi-Laziosi M, Schmidt ML, Niemeyer D, Corman VM, Kraft A, Godel A, Laloli L, Kelly JN, Calderon BM, Breithaupt A, Wylezich C, Berenguer Veiga I, Gultom M, Osman S, Zhou B, Adea K, Meyer B, Eberhardt CS, Thomann L, Gsell M, Labroussaa F, Jores J, Summerfield A, Drosten C, Eckerle IA, We
Published in: Nature, 2022
Publisher: Springer Nature
DOI: 10.1038/s41586-021-04342-0

The value of open-source clinical science in pandemic response: lessons from ISARIC

Author(s): The ISARIC Clinical Characterisation Group
Published in: Lancet Infectious Diseases, 2021
Publisher: Elsevier
DOI: 10.1016/s1473-3099(21)00565-x

Monitoring key epidemiological parameters of SARS-CoV-2 transmission

Author(s): Kraemer MUG, Pybus OG, Fraser C, Cauchemez S, Rambaut A, Cowling BJ
Published in: Nature Medicine, 2021
Publisher: Springer Nature
DOI: 10.1038/s41591-021-01545-w

Monitoring the proportion of the population infected by SARS-CoV-2 using age-stratified hospitalization and serological data: a modelling study

Author(s): Hoze N, Paireau J, Lapidus N, Tran Kiem C, Salje H, Severi G, Touvier M, Zins M, de Lamballerie X, Lévy-Bruhl D, Carrat F, Cauchemez S
Published in: Lancet Public Health, 2021
Publisher: Elsevier
DOI: 10.1016/s2468-2667(21)00064-5

Early assessment of diffusion and possible expansion of SARS-CoV-2 lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021

Author(s): Gaymard A, Bosetti P, Feri A, Destras G, Enouf V, Andronico A, Burrel S, Behillil S, Sauvage C, Bal A, Morfin F, Van Der Werf S, Josset L, ANRS MIE AC43 COVID-19, French viro COVID group, Blanquart F, Coignard B, Cauchemez S, Lina B
Published in: Eurosurveillance, 2021
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2021.26.9.2100133

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

Author(s): Reincke SM, Yuan M, Kornau HC, Corman VM, van Hoof S, Sánchez-Sendin E, Ramberger M, Yu W, Hua Y, Tien H, Schmidt ML, Schwarz T, Jeworowski LM, Brandl SE, Rasmussen HF, Homeyer MA, Stöffler L, Barner M, Kunkel D, Huo S, Horler J, von Wardenburg N, Kroidl I, Eser TM, Wieser A, Geldmacher C, Hoelscher M, Gänzer H, Weiss G, Schmitz D, Drosten C, Prüss H, Wilson IA, Kreye J
Published in: Science, 2022
Publisher: AAAS
DOI: 10.1126/science.abm5835

A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern

Author(s): van Gils MJ, van Willigen HDG, Wynberg E, Han AX, van der Straten K, Burger JA, Poniman M, Oomen M, Tejjani K, Bouhuijs JH, Verveen A, Lebbink R, Dijkstra M, Appelman B, Lavell AHA, Caniels TG, Bontjer I, van Vught LA, Vlaar APJ, Sikkens JJ, Bomers MK, Russell CA, Kootstra NA, Sanders RW, Prins M, de Bree GJ, de Jong MD
Published in: Cell Rep Med, 2021
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2021.100486

Impact of January 2021 curfew measures on SARS-CoV-2 B.1.1.7 circulation in France

Author(s): Laura Di Domenico, Chiara E Sabbatini, Giulia Pullano, Daniel Lévy-Bruhl, Vittoria Colizza
Published in: Eurosurveillance, 2021
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2021.26.15.2100272

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

Author(s): Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Th
Published in: Science, 2021
Publisher: AAAS
DOI: 10.1126/science.abh1823

Projecting the COVID-19 epidemic risk in France for the summer 2021

Author(s): Mattia Mazzoli, Eugenio Valdano, Vittoria Colizza
Published in: Journal of travel medicine, 2021
Publisher: Oxford Academic
DOI: 10.1093/jtm/taab129

Evolution of outcomes for patients hospitalised during the first 9 months of the SARS-CoV-2 pandemic in France: A retrospective national surveillance data analysis

Author(s): Lefrancq N, Paireau J, Hozé N, Courtejoie N, Yazdanpanah Y, Bouadma L, Boëlle PY, Chereau F, Salje H, Cauchemez S
Published in: The Lancet Regional Health - Europe, 2021
Publisher: Elsevier
DOI: 10.1016/j.lanepe.2021.100087

Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021

Author(s): Tober-Lau P, Schwarz T, Hillus D, Spieckermann J, Helbig ET, Lippert LJ, Thibeault C, Koch W, Bergfeld L, Niemeyer D, Mühlemann B, Conrad C, Kasper S, Münn F, Kunitz F, Jones TC, Suttorp N, Drosten C, Sander LE, Kurth F, Corman VM
Published in: Emerg Infect Dis, 2021
Publisher: CDC
DOI: 10.3201/eid2708.210887

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

Author(s): ISARIC Clinical Characterisation Group et al
Published in: eLife, 2021
Publisher: eLife
DOI: 10.7554/elife.70970

SARS-CoV-2 transmission across age groups in France and implications for control

Author(s): Tran Kiem C, Bosetti P, Paireau J, Crepey P, Salje H, Lefrancq N, Fontanet A, Benamouzig D, Boelle PY, Desenclos JC, Opatowski L, Cauchemez S
Published in: Nature Communications, 2021
Publisher: Springer Nature
DOI: 10.1038/s41467-021-27163-1

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Author(s): T. Asano et al
Published in: Science Immunology, 2021
Publisher: AAAS
DOI: 10.1126/sciimmunol.abl4348

Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

Author(s): Schwarz T, Tober-Lau P, Hillus D, Helbig ET, Lippert LJ, Thibeault C, Koch W, Landgraf I, Michel J, Bergfeld L, Niemeyer D, Mühlemann B, Conrad C, Dang-Heine C, Kasper S, Münn F, Kappert K, Nitsche A, Tauber R, Schmidt S, Kopankiewicz P, Bias H, Seybold J, von Kalle C, Jones TC, Suttorp N, Drosten C, Sander LE, Corman VM, Kurth F
Published in: Emerg Infect Dis, 2021
Publisher: CDC
DOI: 10.3201/eid2708.211145

The experience of European hospital-based health care workers on following infection prevention and control procedures and their well-being during the first wave of the COVID-19 pandemic

Author(s): Denise van Hout, Paul Hutchinson, Marta Wanat, Caitlin Pilbeam, Herman Goossens, Sibyl Anthierens, Sarah Tonkin-Crine, Nina Gobat
Published in: PLoS ONE, 2022
Publisher: PLoS ONE
DOI: 10.1371/journal.pone.0245182

Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses

Author(s): Schulze, J., Mache, C., Balázs, A., Frey, D., Niemeyer, D., Olze, H., Dommerich, S., Drosten, C., Hocke, A. C., Mall, M. A., Hippenstiel, S., & Wolff, T
Published in: The Journal of infectious diseases, 2021
Publisher: Oxford Academic
DOI: 10.1093/infdis/jiab523

The European clinical research response to optimise treatment of patients with COVID-19: lessons learned, future perspective, and recommendations

Author(s): Goossens H, Horby P, Derde L, Bonten M
Published in: Lancet Infect Dis, 2021
Publisher: The Lancet
DOI: 10.1016/s1473-3099(21)00705-2

Impact of mass testing during an epidemic rebound of SARS-CoV-2: a modelling study using the example of France

Author(s): Bosetti P, Tran Kiem C, Yazdanpanah Y, Fontanet A, Lina B, Colizza V, Cauchemez S
Published in: Eurosurveillance, 2021
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2020.26.1.2001978

Conditionality of COVID-19 vaccine acceptance in European countries

Author(s): Leonardo W. Heyerdahl, Muriel Vray, Benedetta Lana, Nastassia Tvardik, Nina Gobat, Marta Wanat, Sarah Tonkin-Crine, Sibyl Anthierens, Herman Goossens, Tamara Giles-Vernick
Published in: Vaccine, 2022
Publisher: Elsevier
DOI: 10.1016/j.vaccine.2022.01.054

Seasonal coronavirus-specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19

Author(s): Aguilar-Bretones M, Westerhuis BM, Raadsen MP, de Bruin E, Chandler FD, Okba NM, Haagmans BL, Langerak T, Endeman H, van den Akker JP, Gommers DA, van Gorp EC, GeurtsvanKessel CH, de Vries RD, Fouchier RA, Rockx BH, Koopmans MP, van Nierop GP
Published in: The Journal of Clinical Investigation, 2021
Publisher: ASCI
DOI: 10.1172/jci150613

Regular universal screening for SARS-CoV-2 infection may not allow reopening of society after controlling a pandemic wave

Author(s): MCJ Bootsma, ME Kretzschmar, G Rozhnova, JAP Heesterbeek, JAJW Kluytmans, MJM Bonten
Published in: medrxiv, Preprint server, 2020
Publisher: BMJ
DOI: 10.1101/2020.11.18.20233122

Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody

Author(s): 39. Li T, Cai H, Zhao Y, Li Y, Lai Y, Yao H, Liu LD, Sun Z, van Vlissingen MF, Kuiken T, GeurtsvanKessel CH, Zhang N, Zhou B, Lu L, Gong Y, Qin W, Mondal M, Duan B, Xu S, Richard AS, Raoul H, Chen J, Xu C, Wu L, Zhou H, Huang Z, Zhang X, Li J, Wang Y, Bi Y, Rockx B, Chen J, Meng FL, Lavillette D, Li D
Published in: EMBO Molecular Medicine, 2021
Publisher: EMBOpress
DOI: 10.15252/emmm.202114544

Prospective SARS-CoV-2 cohort study among primary health care providers during the second COVID-19 wave in Flanders, Belgium

Author(s): Mariën, J., Ceulemans A., Bakokimi D, Lammens C., Ieven M., Heytens S., De Sutter A., Verbakel, J. Y., Van den Bruel A., Goossens H., Van Damme P., Arië, K. K. , and Coenen S.
Published in: Family Practice, 2022
Publisher: Oxford Academic
DOI: 10.1093/fampra/cmab094

Screening and vaccination against COVID-19 to minimize school closure: a modeling study

Author(s): Elisabetta Colosi, Giulia Bassignana, Diego Andrés Contreras, Canelle Poirier, Pierre-Yves Boëlle, Simon Cauchemez, Yazdan Yazdanpanah, Bruno Lina, Arnaud Fontanet, Alain Barrat, Vittoria Colizza
Published in: Lancet Infectious Diseases, 2021
Publisher: BMJ Yale
DOI: 10.1101/2021.08.15.21261243

Evaluation of a throat spray with lactobacilli in COVID-19 outpatients in a randomized, double-blind, placebo-controlled trial for symptom and viral load reduction

Author(s): De Boeck I., Cauwenberghs E., Spacova I., Gehrmann T., Eilers T., Delanghe I., Wittouck S., Bron P.A., Henkens T., Gamgami I., Simons A., Claes I., Mariën J., Ariën K.K., Bakokimi D. , Loens K., Jacobs K., a Ieven M., Bruijning-Verhagen P., Delputte P., Coenen S., Verhoeven V., Lebeer S
Published in: Clinical Microbiology and Infection, 2022
Publisher: BMJ Yale
DOI: 10.1101/2022.03.17.22272401

Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variants

Author(s): Mertens J. Coppens J., Loens K., Le Mercier M., Xavier B. B., Lammens C., Vandamme S., Jansens H., Goossens H., and Matheeussen V
Published in: Clinical Microbiology and Infection, 2022
Publisher: Elsevier
DOI: 10.1016/j.cmi.2021.09.007

A modelling study investigating short and medium-term challenges for COVID-19 vaccination: From prioritisation to the relaxation of measures

Author(s): Tran Kiem C, Massonnaud CR, Levy-Bruhl D, Poletto C, Colizza V, Bosetti P, Fontanet A, Gabet A, Olié V, Zanetti L, Boëlle PY, Crépey P, Cauchemez S
Published in: EClinicalMedicine, 2021
Publisher: Lancet
DOI: 10.1016/j.eclinm.2021.101001

From more testing to smart testing: data-guided SARS-CoV-2 testing choices, the Netherlands, May to September 2020

Author(s): van Beek Janko, Igloi Zsofia, Boelsums Timo, Fanoy Ewout, Gotz Hannelore, Molenkamp Richard, van Kampen Jeroen, GeurtsvanKessel Corine, van der Eijk Annemiek A, van de Vijver David, Koopmans Marion
Published in: Eurosurveillance, 2022
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2022.27.8.2100702

Benefits and risks associated with different uses of the COVID-19 vaccine Vaxzevria: a modelling study, France, May to September 2021

Author(s): Tran Kiem C, Andronico A, Bosetti P, Paireau J, Alter L, Boëlle PY, Fontanet A, Lévy-Bruhl D, Cauchemez S
Published in: Eurosurveillance, 2021
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2021.26.26.2100533

Transmission of SARS-CoV-2 within households: a prospective cohort study in the Netherlands and Belgium – Interim results

Author(s): JDM Verberk, MLA de Hoog, I Westerhof, S Van Goethem, C Lammens, M Ieven, E de Bruin, J Bielicki, S Coenen, J van Beek, M Bonten, H Goossens, PCJL Bruijning-Verhagen
Published in: Medrxiv, 2021
Publisher: BMJ Yale
DOI: 10.1101/2021.04.23.21255846

The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies

Author(s): J. Manry et al
Published in: Research Square, 2022
Publisher: Research Square Company
DOI: 10.21203/rs.3.rs-1225906/v1

Adherence and sustainability of interventions informing optimal control against the COVID-19 pandemic

Author(s): Laura Di Domenico, Chiara E Sabbatini, Pierre-Yves Boëlle, Chiara Poletto, Pascal Crépey, Juliette Paireau, Simon Cauchemez, François Beck, Harold Noel, Daniel Lévy-Bruhl, Vittoria Colizza
Published in: Communications Medicine, 2021
Publisher: Springer Nature
DOI: 10.1038/s43856-021-00057-5

Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths

Author(s): Bastard P et al
Published in: Science Immunology, 2021
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.abl4340

Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study

Author(s): Mühlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Müller MA; Pa-COVID-19 collaborative study group, Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F
Published in: Clin Microbiol Infect, 2021
Publisher: Elsevier
DOI: 10.1016/j.cmi.2021.06.008

Evaluating the impact of curfews and other measures on SARS-CoV-2 transmission in French Guiana

Author(s): Andronico A, Tran Kiem C, Paireau J, Succo T, Bosettit P, Lefrancq N, Nacher M, Djossou F, Sanna A, Flamand C, Salje H, Rousseau C, Cauchemez S
Published in: Nature Communications, 2021
Publisher: Nature Springer
DOI: 10.1038/s41467-021-21944-4

Following the science? Views from scientists on government advisory boards during the COVID-19 pandemic: a qualitative interview study in five European countries

Author(s): Elien Colman, Marta Wanat, Herman Goossens, Sarah Tonkin-Crine, Sibyl Anthierens
Published in: BMJ Global Health, 6/9, 2021, Page(s) e006928, ISSN 2059-7908
Publisher: BMJ
DOI: 10.1136/bmjgh-2021-006928

International external quality assessment for SARS-CoV-2 molecular detection and survey on clinical laboratory preparedness during the COVID-19 pandemic, April/May 2020

Author(s): Veerle Matheeussen, Victor M Corman, Oliver Donoso Mantke, Elaine McCulloch, Christine Lammens, Herman Goossens, Daniela Niemeyer, Paul S Wallace, Paul Klapper, Hubert GM Niesters, Christian Drosten, Margareta Ieven
Published in: Eurosurveillance, 25/27, 2020, ISSN 1560-7917
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2020.25.27.2001223

Lockdown as a last resort option in case of COVID-19 epidemic rebound: a modelling study

Author(s): Cécile Tran Kiem, Pascal Crépey, Paolo Bosetti, Daniel Levy Bruhl, Yazdan Yazdanpanah, Henrik Salje, Pierre-Yves Boëlle, Simon Cauchemez
Published in: Eurosurveillance, 26/22, 2021, ISSN 1560-7917
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2021.26.22.2001536

Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020

Author(s): Isabelle Sermet-Gaudelus, Sarah Temmam, Christèle Huon, Sylvie Behillil, Vincent Gajdos, Thomas Bigot, Thibaut Lurier, Delphine Chrétien, Marija Backovic, Agnès Delaunay-Moisan, Flora Donati, Mélanie Albert, Elsa Foucaud, Bettina Mesplées, Grégoire Benoist, Albert Faye, Marc Duval-Arnould, Célia Cretolle, Marina Charbit, Mélodie Aubart, Johanne Auriau, Mathie Lorrot, Dulanjalee Kariyawasam
Published in: Eurosurveillance, 26/13, 2021, ISSN 1560-7917
Publisher: Eurosurveillance
DOI: 10.2807/1560-7917.es.2021.26.13.2001782

Transformation of primary care during the COVID-19 pandemic: experiences of healthcare professionals in eight European countries

Author(s): Marta Wanat, Melanie Hoste, Nina Gobat, Marilena Anastasaki, Femke Böhmer, Slawomir Chlabicz, Annelies Colliers, Karen Farrell, Maria-Nefeli Karkana, John Kinsman, Christos Lionis, Ludmila Marcinowicz, Katrin Reinhardt, Ingmarie Skoglund, Pär-Daniel Sundvall, Akke Vellinga, Theo JM Verheij, Herman Goossens, Christopher C Butler, Alike van der Velden, Sibyl Anthierens, Sarah Tonkin-Crine
Published in: British Journal of General Practice, 71/709, 2021, Page(s) e634-e642, ISSN 0960-1643
Publisher: Royal College of General Practitioners
DOI: 10.3399/bjgp.2020.1112

Monitoring approaches for health-care workers during the COVID-19 pandemic

Author(s): Julia A Bielicki, Xavier Duval, Nina Gobat, Herman Goossens, Marion Koopmans, Evelina Tacconelli, Sylvie van der Werf
Published in: The Lancet Infectious Diseases, 20/10, 2020, Page(s) e261-e267, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(20)30458-8

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Author(s): REMAP-CAP Investigators, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, May
Published in: New England Journal of Medicine, 384/16, 2021, Page(s) 1491-1502, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmoa2100433

Experiences and needs of persons living with a household member infected with SARS-CoV-2: A mixed method study

Author(s): Janneke D. M. Verberk, Sibyl A. Anthierens, Sarah Tonkin-Crine, Herman Goossens, John Kinsman, Marieke L. A. de Hoog, Julia A. Bielicki, Patricia C. J. L. Bruijning-Verhagen, Nina H. Gobat
Published in: PLOS ONE, 16/3, 2021, Page(s) e0249391, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0249391

A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection

Author(s): Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry R
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24905-z

Preparedness of European diagnostic microbiology labs for detection of SARS-CoV-2, March 2020

Author(s): Veerle Matheeussen, Katherine Loens, Christine Lammens, Tuba Vilken, Marion Koopmans, Herman Goossens, Margareta Ieven
Published in: Journal of Clinical Virology, 128, 2020, Page(s) 104432, ISSN 1386-6532
Publisher: Elsevier BV
DOI: 10.1016/j.jcv.2020.104432

Evaluating the effect of demographic factors, socioeconomic factors, and risk aversion on mobility during the COVID-19 epidemic in France under lockdown: a population-based study

Author(s): Giulia Pullano, Eugenio Valdano, Nicola Scarpa, Stefania Rubrichi, Vittoria Colizza
Published in: The Lancet Digital Health, 2/12, 2020, Page(s) e638-e649, ISSN 2589-7500
Publisher: Elsevier BV
DOI: 10.1016/s2589-7500(20)30243-0

A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

Author(s): Ludivine Grzelak, Sarah Temmam, Cyril Planchais, Caroline Demeret, Laura Tondeur, Christèle Huon, Florence Guivel-Benhassine, Isabelle Staropoli, Maxime Chazal, Jeremy Dufloo, Delphine Planas, Julian Buchrieser, Maaran Michael Rajah, Remy Robinot, Françoise Porrot, Mélanie Albert, Kuang-Yu Chen, Bernadette Crescenzo-Chaigne, Flora Donati, François Anna, Philippe Souque, Marion Gransagne, Jacqu
Published in: Science Translational Medicine, 12/559, 2020, Page(s) eabc3103, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abc3103

High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

Author(s): Sarah Tubiana, Charles Burdet, Nadhira Houhou, Michael Thy, Pauline Manchon, François Blanquart, Charlotte Charpentier, Jérémie Guedj, Loubna Alavoine, Sylvie Behillil, Anne Leclercq, Jean-Christophe Lucet, Yazdan Yazdanpanah, Mikaël Attia, Caroline Demeret, Thierry Rose, Julia Anna Bielicki, Patricia Bruijning-Verhagen, Herman Goossens, Diane Descamps, Sylvie van der Werf, Bruno Lina, Xavier
Published in: Journal of Infection, 82/5, 2021, Page(s) 186-230, ISSN 0163-4453
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2021.01.026

Primary care for patients with respiratory tract infection before and early on in the COVID-19 pandemic: an observational study in 16 European countries

Author(s): Alike W van der Velden, Eva A Bax, Emily Bongard, Rune Munck Aabenhus, Marilena Anastasaki, Sibyl Anthierens, Anca Balan, Femke Böhmer, Pascale Bruno, Slawomir Chlabicz, Samuel Coenen, Annelies Colliers, Susanne Emmerich, Ana Garcia-Sangenis, Hrachuhi Ghazaryan, Sanne R van der Linde, Lile Malania, József Pauer, Angela Tomacinschii, Sarah Tonkin-Crine, Akke Vellinga, Ihor Zastavnyy, Theo Verheij
Published in: BMJ Open, 11/7, 2021, Page(s) e049257, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-049257

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

Author(s): Simon Schroeder, Fabian Pott, Daniela Niemeyer, Talitha Veith, Anja Richter, Doreen Muth, Christine Goffinet, Marcel A Müller, Christian Drosten
Published in: The Lancet Microbe, 2021, ISSN 2666-5247
Publisher: Elsevier BV
DOI: 10.1016/s2666-5247(21)00027-6

Performance of the FREND™ COVID-19 IgG/IgM Duo point-of-care test for SARS-CoV-2 antibody detection

Author(s): Dorien G. De Munck, Bart Peeters, Evelyne Huyghe, Herman Goossens, Margareta Ieven, Veerle Matheeussen
Published in: Acta Clinica Belgica, 2021, Page(s) 1-6, ISSN 1784-3286
Publisher: Taylor & Francis Production
DOI: 10.1080/17843286.2021.1940776

Face coverings for covid-19: from medical intervention to social practice

Author(s): Helene-Mari van der Westhuizen, Koot Kotze, Sarah Tonkin-Crine, Nina Gobat, Trisha Greenhalgh
Published in: BMJ, 2020, Page(s) m3021, ISSN 1756-1833
Publisher: BMJ
DOI: 10.1136/bmj.m3021

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

Author(s): Jeroen J. A. van Kampen, David A. M. C. van de Vijver, Pieter L. A. Fraaij, Bart L. Haagmans, Mart M. Lamers, Nisreen Okba, Johannes P. C. van den Akker, Henrik Endeman, Diederik A. M. P. J. Gommers, Jan J. Cornelissen, Rogier A. S. Hoek, Menno M. van der Eerden, Dennis A. Hesselink, Herold J. Metselaar, Annelies Verbon, Jurriaan E. M. de Steenwinkel, Georgina I. Aron, Eric C. M. van Gorp, Sander
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20568-4

Model-based evaluation of school- and non-school-related measures to control the COVID-19 pandemic

Author(s): Ganna Rozhnova, Christiaan H. van Dorp, Patricia Bruijning-Verhagen, Martin C. J. Bootsma, Janneke H. H. M. van de Wijgert, Marc J. M. Bonten, Mirjam E. Kretzschmar
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21899-6

Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study

Author(s): Victor M Corman, Verena Claudia Haage, Tobias Bleicker, Marie Luisa Schmidt, Barbara Mühlemann, Marta Zuchowski, Wendy K Jo, Patricia Tscheak, Elisabeth Möncke-Buchner, Marcel A Müller, Andi Krumbholz, Jan Felix Drexler, Christian Drosten
Published in: The Lancet Microbe, 2021, ISSN 2666-5247
Publisher: Elsevier BV
DOI: 10.1016/s2666-5247(21)00056-2

Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans

Author(s): Bas B. Oude Munnink, Reina S. Sikkema, David F. Nieuwenhuijse, Robert Jan Molenaar, Emmanuelle Munger, Richard Molenkamp, Arco van der Spek, Paulien Tolsma, Ariene Rietveld, Miranda Brouwer, Noortje Bouwmeester-Vincken, Frank Harders, Renate Hakze-van der Honing, Marjolein C. A. Wegdam-Blans, Ruth J. Bouwstra, Corine GeurtsvanKessel, Annemiek A. van der Eijk, Francisca C. Velkers, Lidwien A. M. Sm
Published in: Science, 371/6525, 2021, Page(s) 172-177, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abe5901

Comparison of commercial realtime reverse transcription PCR assays for the detection of SARS-CoV-2

Author(s): Zsófia Iglói, Margareta leven, Zain Abdel-Karem Abou-Nouar, Babette Weller, Veerle Matheeussen, Jasmine Coppens, Marion Koopmans, Richard Molenkamp
Published in: Journal of Clinical Virology, 129, 2020, Page(s) 104510, ISSN 1386-6532
Publisher: Elsevier BV
DOI: 10.1016/j.jcv.2020.104510

Tracing and analysis of 288 early SARS-CoV-2 infections outside China: A modeling study

Author(s): Francesco Pinotti, Laura Di Domenico, Ernesto Ortega, Marco Mancastroppa, Giulia Pullano, Eugenio Valdano, Pierre-Yves Boëlle, Chiara Poletto, Vittoria Colizza
Published in: PLOS Medicine, 17/7, 2020, Page(s) e1003193, ISSN 1549-1676
Publisher: PLOS Medicine
DOI: 10.1371/journal.pmed.1003193