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Prevention of SARS-CoV-2 infection through development and clinical testing of a novel Virus Like Particle (VLP) vaccine

Deliverables

Updated Data Management Plan

Task to comply with ORDP requirement for public health emergency

Dissemination and communication plan final

Dissemination and communication plan final

Dissemination and communication plan

Dissemination and communication plan

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Publications

A Capsid Virus-Like Particle-Based SARS-CoV-2 Vaccine Induces High Levels of Antibodies and Protects Rhesus Macaques

Author(s): Volkmann A, Koopman G, Mooij P, Verschoor EJ, Verstrepen BE, Bogers WMJM, Idorn M, Paludan SR, Vang S, Nielsen MA, Sander AF, Schmittwolf C, Hochrein H and Chaplin P
Published in: Front. Immunol, 16643224, 2022, ISSN 1664-3224
Publisher: PMCID
DOI: 10.3389/fimmu.2022.857440

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

Author(s): Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K. Myeni, Robert Dagil, Christoph M. Janitzek, Max Søgaard, Kara-Lee Aves, Emma W. Horsted, Sayit Mahmut Erdoğan, Tobias Gustavsson, Jerzy Dorosz, Stine Clemmensen, Laurits Fredsgaard, Susan Thrane, Elena E. Vidal-Calvo, Paul Khalifé, Thomas M. Hulen, Swati Choudhary, Michael Theisen, Susheel K. Singh, Asier Garcia-Se
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20251-8

Two-component nanoparticle vaccine displaying glycosylated spike S1 domain induces neutralizing antibody response against SARS-CoV-2 variants

Author(s): van Oosten L, Altenburg JJ, Fougeroux C, Geertsema C, van den End F, Evers WAC, Westphal AH, Lindhoud S, van den Berg W, Swarts DC, Deurhof L, Suhrbier A, Le TT, Torres Morales S, Myeni SK, Kikkert M, Sander AF, de Jongh WA, Dagil R, Nielsen MA, Salanti A, Søgaard M, Keijzer TMP, Weijers D, Eppink MHM, Wijffels RH, van Oers MM, Martens DE, Pijlman GP
Published in: mBio, 21507511, 2021, ISSN 2150-7511
Publisher: ASM Journal
DOI: 10.1128/mbio.01813-21

An S1-Nanoparticle Vaccine Protects against SARS-CoV-2 Challenge in K18-hACE2 Mice

Author(s): Linda van Oosten, Kexin Yan, Daniel J Rawle, Thuy T Le, Jort J Altenburg, Cyrielle Fougeroux, Louise Goksøyr, Willem Adriaan de Jongh, Morten A Nielsen, Adam F Sander, Gorben P Pijlman, Andreas Suhrbier
Published in: Journal of Virology, 10985514, 2022, ISSN 1098-5514
Publisher: ASM Journal
DOI: 10.1128/jvi.00844-22