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Development of Impentri, an intravenous imatinib formulation for Covid-19 acute respiratory distress syndrome (ARDS).

Deliverables

'Oral imatinib in severe Covid-19' study peer reviewed publication

Peer reviewed publication reporting findings from the oral Phase II clinical study

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Publications

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

Author(s): Jurjan Aman, Erik Duijvelaar, Liza Botros, Azar Kianzad, Job R Schippers, Patrick J Smeele, Sara Azhang, Imke H Bartelink, Ahmed A Bayoumy, Pierre M Bet, Wim Boersma, Peter I Bonta, Karin A T Boomars, Lieuwe D J Bos, Job J M H van Bragt, Gert-Jan Braunstahl, Lucas R Celant, Katrien A B Eger, J J Miranda Geelhoed, Yurika L E van Glabbeek, Hans P Grotjohan, Laura A Hagens, Chris M Happe, Boaz D Haze
Published in: The Lancet Respiratory Medicine, Issue 9/9, 2021, Page(s) 957-968, ISSN 2213-2600
DOI: 10.1016/s2213-2600(21)00237-x

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

Author(s): Jurjan Aman, Erik Duijvelaar, Liza Botros, Azar Kianzad, Job R Schippers, Patrick J Smeele, Sara Azhang, Imke H Bartelink, Ahmed A Bayoumy, Pierre M Bet, Wim Boersma, Peter I Bonta, Karin A T Boomars, Lieuwe D J Bos, Job J M H van Bragt, Gert-Jan Braunstahl, Lucas R Celant, Katrien A B Eger, J J Miranda Geelhoed, Yurika L E van Glabbeek, Hans P Grotjohan, Laura A Hagens, Chris M Happe, Boaz D Haze
Published in: The Lancet Respiratory Medicine, 2021, ISSN 2213-2600
DOI: 10.1016/s2213-2600(21)00237-x

Elevated acute phase proteins affect pharmacokinetics in COVID‐19 trials: Lessons from the CounterCOVID ‐ imatinib study

Author(s): Imke H. Bartelink, Pierre M. Bet, Nicolas Widmer, Monia Guidi, Erik Duijvelaar, Bram Grob, Richard Honeywell, Amanda Evelo, Ivo P. E. Tielbeek, Sue D. Snape, Henrike Hamer, Laurent A. Decosterd, Harm Jan Bogaard, Jurjan Aman, Eleonora L. Swart
Published in: CPT: Pharmacometrics & Systems Pharmacology, Issue 5 October 2021, 2021, ISSN 2163-8306
DOI: 10.1002/psp4.12718